NR3C1 angl Nuclear receptor subfamily 3 group C member 1 bilok yakij koduyetsya odnojmennim genom roztashovanim u lyudej na korotkomu plechi 5 yi hromosomi 6 Dovzhina polipeptidnogo lancyuga bilka stanovit 777 aminokislot a molekulyarna masa 85 659 7 NR3C1Nayavni strukturiPDBPoshuk ortologiv PDBe RCSBSpisok kodiv PDB1M2Z 1NHZ 1P93 3BQD 3CLD 3E7C 3H52 3K22 3K23 4CSJ 4HN5 4HN6 4LSJ 4MDD 4P6W 4P6X 5CBY 5CBX 4UDC 4UDD 5CBZ 5CC1 5EMQ 5EMC 5EMPIdentifikatoriSimvoliNR3C1 GCCR GCR GCRST GR GRL nuclear receptor subfamily 3 group C member 1 Glucocorticoid ReceptorZovnishni ID OMIM 138040 MGI 95824 HomoloGene 30960 GeneCards NR3C1Pov yazani genetichni zahvoryuvannyaglucocorticoid resistance 1 Reaguye na spolukuMometazon triamcinolon prednizolon 2 Budesonid ciclesonide clobetasol propionate Kortizol deoxycorticosterone desoximetasone deksametazon difluprednate fluocinolone acetonide fluocinonide fluorometholone flutikazon fluticasone propionate metilprednizolon prednizolon prednizon RU28362 triamcinolon triamcinolone acetonide betametazon Mifepriston 3 Ontologiya genaMolekulyarna funkciya steroid hormone binding DNA binding sequence specific DNA binding GO 0001131 GO 0001151 GO 0001130 GO 0001204 DNA binding transcription factor activity zinc ion binding GO 0001077 GO 0001212 GO 0001213 GO 0001211 GO 0001205 DNA binding transcription activator activity RNA polymerase II specific glucocorticoid receptor activity GO 0038050 GO 0004886 GO 0038051 nuclear receptor activity zv yazuvannya z ionom metalu GO 0000980 RNA polymerase II cis regulatory region sequence specific DNA binding steroid hormone receptor activity steroid binding GO 0001948 GO 0016582 protein binding lipid binding RNA binding SUMO binding Hsp90 protein binding GO 0001200 GO 0001133 GO 0001201 DNA binding transcription factor activity RNA polymerase II specific protein kinase bindingKlitinna komponenta citoplazma Nukleoplazma mitohondrialnij matriks mitohondriya klitinne yadro Citoskelet Vereteno podilu Centr organizaciyi mikrotrubochok gialoplazma nuclear speck GO 0009327 protein containing complexBiologichnij proces cellular response to steroid hormone stimulus GO 0009373 regulation of transcription DNA templated glucocorticoid mediated signaling pathway transcription by RNA polymerase II transcription initiation from RNA polymerase II promoter glucocorticoid receptor signaling pathway GO 0072468 Signalna transdukciya steroid hormone mediated signaling pathway klitinnij cikl podil klitini GO 0097285 Apoptoz chromosome segregation GO 1901227 negative regulation of transcription by RNA polymerase II transcription DNA templated cellular response to dexamethasone stimulus cellular response to transforming growth factor beta stimulus GO 0003257 GO 0010735 GO 1901228 GO 1900622 GO 1904488 positive regulation of transcription by RNA polymerase II cellular response to glucocorticoid stimulus GO 0031497 GO 0006336 GO 0034724 GO 0001301 GO 0007580 GO 0034652 GO 0010847 chromatin organization positive regulation of pri miRNA transcription by RNA polymerase IIDzherela Amigo QuickGOShablon ekspresiyiBilshe danihOrtologiVidi Lyudina MishaEntrez2908 14815Ensembl ENSG00000113580 ENSMUSG00000024431UniProt P04150Q3MSN4 P06537RefSeq mRNK NM 000176NM 001018074NM 001018075NM 001018076NM 001018077NM 001020825NM 001024094NM 001204258NM 001204259NM 001204260NM 001204261NM 001204262NM 001204263NM 001204264NM 001204265NM 001364180NM 001364181NM 001364182NM 001364183NM 001364184NM 001364185NM 008173NM 001361209NM 001361210NM 001361211NM 001361212RefSeq bilok NP 000167NP 001018084NP 001018085NP 001018086NP 001018087NP 001018661NP 001019265NP 001191187NP 001191188NP 001191189NP 001191190NP 001191191NP 001191192NP 001191193NP 001191194NP 001351109NP 001351110NP 001351111NP 001351112NP 001351113NP 001351114NP 000167 1NP 001018084 1NP 001018085 1NP 001018086 1NP 001018087 1NP 001018661 1NP 001019265 1NP 001191187 1NP 001191188 1NP 001191189 1NP 001191190 1NP 001191191 1NP 001191192 1NP 001191193 1NP 001348138NP 001348139NP 001348140NP 001348141NP 032199Lokus UCSC Hr 5 143 28 143 44 MbHr 18 39 54 39 65 MbPubMed search 4 5 VikidaniDiv Red dlya lyudejDiv Red dlya mishej Poslidovnist aminokislot1020304050MDSKESLTPGREENPSSVLAQERGDVMDFYKTLRGGATVKVSASSPSLAVASQSDSKQRRLLVDFPKGSVSNAQQPDLSKAVSLSMGLYMGETETKVMGNDLGFPQQGQISLSSGETDLKLLEESIANLNRSTSVPENPKSSASTAVSAAPTEKEFPKTHSDVSSEQQHLKGQTGTNGGNVKLYTTDQSTFDILQDLEFSSGSPGKETNESPWRSDLLIDENCLLSPLAGEDDSFLLEGNSNEDCKPLILPDTKPKIKDNGDLVLSSPSNVTLPQVKTEKEDFIELCTPGVIKQEKLGTVYCQASFPGANIIGNKMSAISVHGVSTSGGQMYHYDMNTASLSQQQDQKPIFNVIPPIPVGSENWNRCQGSGDDNLTSLGTLNFPGRTVFSNGYSSPSMRPDVSSPPSSSSTATTGPPPKLCLVCSDEASGCHYGVLTCGSCKVFFKRAVEGQHNYLCAGRNDCIIDKIRRKNCPACRYRKCLQAGMNLEARKTKKKIKGIQQATTGVSQETSENPGNKTIVPATLPQLTPTLVSLLEVIEPEVLYAGYDSSVPDSTWRIMTTLNMLGGRQVIAAVKWAKAIPGFRNLHLDDQMTLLQYSWMFLMAFALGWRSYRQSSANLLCFAPDLIINEQRMTLPCMYDQCKHMLYVSSELHRLQVSYEEYLCMKTLLLLSSVPKDGLKSQELFDEIRMTYIKELGKAIVKREGNSSQNWQRFYQLTKLLDSMHEVVENLLNYCFQTFLDKTMSIEFPEMLAEIITNQIPKYSNGNIKKLLFHQKA Alanin C Cisteyin D Asparaginova kislota E Glutaminova kislota F Fenilalanin G Glicin H Gistidin I Izolejcin K Lizin L Lejcin M Metionin N Asparagin P Prolin Q Glutamin R Arginin S Serin T Treonin V Valin W Triptofan Y Tirozin Kodovanij genom bilok za funkciyami nalezhit do receptoriv regulyatoriv hromatinu fosfoproteyiniv Zadiyanij u takih biologichnih procesah yak apoptoz transkripciya regulyaciya transkripciyi klitinnij cikl podil klitini mitoz rozhodzhennya hromosom polimorfizm acetilyuvannya alternativnij splajsing Bilok maye sajt dlya zv yazuvannya z lipidami ionami metaliv ionom cinku DNK RNK steroyidami Lokalizovanij u citoplazmi citoskeleti yadri mitohondriyi Literatura RedaguvatiTurner J D Schote A B Keipes M Muller C P 2007 A new transcript splice variant of the human glucocorticoid receptor identification and tissue distribution of hGR Delta 313 338 an alternative exon 2 transactivation domain isoform Ann N Y Acad Sci 1095 334 341 PubMed DOI 10 1196 annals 1397 037 The status quality and expansion of the NIH full length cDNA project the Mammalian Gene Collection MGC Genome Res 14 2121 2127 2004 PubMed DOI 10 1101 gr 2596504 Govindan M V Pothier F Leclerc S Palaniswami R Xie B 1991 Human glucocorticoid receptor gene promotor homologous down regulation J Steroid Biochem Mol Biol 40 317 323 PubMed DOI 10 1016 0960 0760 91 90197 D Weinberger C Hollenberg S M Rosenfeld M G Evans R M 1985 Domain structure of human glucocorticoid receptor and its relationship to the v erb A oncogene product Nature 318 670 672 PubMed DOI 10 1038 318670a0 Bamberger C M Bamberger A M de Castro M Chrousos G P 1995 Glucocorticoid receptor beta a potential endogenous inhibitor of glucocorticoid action in humans J Clin Invest 95 2435 2441 PubMed DOI 10 1172 JCI117943 Oakley R H Sar M Cidlowski J A 1996 The human glucocorticoid receptor beta isoform Expression biochemical properties and putative function J Biol Chem 271 9550 9559 PubMed DOI 10 1074 jbc 271 16 9550Primitki Redaguvati Zahvoryuvannya genetichno pov yazani z NR3C1 pereglyanuti redaguvati posilannya na VikiDanih Spoluki yaki fizichno vzayemodiyut z Glucocorticoid receptor pereglyanuti redaguvati posilannya na VikiDanih Spoluki yaki fizichno vzayemodiyut z Nuclear receptor subfamily 3 group C member 1 pereglyanuti redaguvati posilannya na VikiDanih Human PubMed Reference Mouse PubMed Reference HUGO Gene Nomenclature Commitee HGNC 7978 angl Procitovano 31 serpnya 2017 UniProt P04150 angl Arhiv originalu za 1 veresnya 2017 Procitovano 31 serpnya 2017 Div takozh RedaguvatiHromosoma 5 nbsp Ce nezavershena stattya pro bilki Vi mozhete dopomogti proyektu vipravivshi abo dopisavshi yiyi Otrimano z https uk wikipedia org w index php title Glyukokortikoyidnij receptor amp oldid 36130079
