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Cya stattya ye sirim perekladom z inshoyi movi Mozhlivo vona stvorena za dopomogoyu mashinnogo perekladu abo perekladachem yakij nedostatno volodiye oboma movami Bud laska dopomozhit polipshiti pereklad serpen 2020 Acetilyuvannya abo etanoyilyuvannya vidpovidno do nomenklaturi IUPAC ce reakciya vvedennya acetilnoyi funkcionalnoyi grupi do himichnoyi molekuli za uchasti fermenta acetiltrasferazi Deacetilyuvannya ce vidalennya acetilnoyi grupi Acetilovannya salicilovoyi kisloti z utvorennyam aspirinuAcetilyuvannya stosuyetsya procesu vvedennya acetilnoyi grupi v rezultati chogo utvoryuyetsya acetoksi grupa en do molekuli a same zamishennya acetilnoyu grupoyu protonu vodnyu en Reakciyu z zaminoyu protonu vodnyu v gidroksilnij grupi na acetilnu grupu SN3SO utvoryuye skladnij efir yakij nazivayut acetatom Zazvichaj vikoristovuyut octovij angidrid yak acetilyuyuchij agent yakij reaguye z vilnimi gidroksilnimi grupami Takim chinom sintezuyut aspirin geroyin ta THC O acetat en Zmist 1 Acetilyuvannya bilkiv 1 1 N terminalne acetilyuvannya 1 1 1 N kincevi acetiltransferazi 1 1 1 1 NatA 1 1 1 2 NatB 1 1 1 3 NatC 1 1 1 4 NatD 1 1 1 5 NatE 1 1 1 6 NatF 1 1 1 7 NAA80 NatH 1 1 2 N kinceva funkciya acetilyuvannya 1 1 2 1 Stabilizaciya bilkiv 1 1 2 2 Lokalizaciya bilka 1 1 2 3 Metabolizm ta apoptoz 1 1 2 4 Sintez bilka 1 1 3 Rak 1 2 Acetilyuvannya i deacetilyuvannya lizinu 1 2 1 p53 1 2 1 1 Acetilyuvannya r53 1 2 1 2 Naslidki dlya terapiyi raku 1 2 2 Mikrotrubochka 1 2 2 1 Acetilyuvannya tubulinu 1 2 2 2 Naslidki dlya terapiyi raku 1 2 3 STAT3 1 2 3 1 Acetilyuvannya STAT3 1 2 3 2 Terapevtichni naslidki dlya terapiyi raku 2 Acetilyuvannya derevini 3 Div takozh 4 PrimitkiAcetilyuvannya bilkiv RedaguvatiAcetilyuvannya vazhliva modifikaciya bilkiv u klitinnij biologiyi Doslidzhennya z proteomiki identifikuvali tisyachi acetilovanih bilkiv u ssavciv 1 2 3 Acetilyuvannya vidbuvayetsya yak ko translyacijna ta posttranslyacijna modifikaciya bilkiv shlyahom kovalentnogo priyednannya do nih acetilnih grup sho vidbivayetsya na yih funkcionalnij aktivnosti napriklad gistoniv p53 ta tubuliniv Lokalne acetilyuvannya N kincevih uchasnikiv gistoniv na posttranslyacijnomu rivni pov yazane iz aktivaciyeyu hromatinu Taki fermenti yak gistonovi acetiltransferazi ta deacetilazi berut uchast v acetilyuvanni chi deacetilyuvanni gistoniv regulyuyuchi ekspresiyu ta transkripciyu geniv Acetilyuvannya bilka p53 po COOH kincyu stimulyuye jogo zdatnist zv yazuvatisya iz DNK Taki modifikaciyi masovo predstavleni sered hromatinovih bilkiv ta fermentiv klitinnogo metabolizmu sho svidchit pro te sho acetilyuvannya maye znachnij vpliv na epigenom div Epigenomika sho v svoyu chergu vplivaye na ekspresiyu geniv ta metabolizm U bakterij 90 bilkiv yaki berut uchast u centralnomu obmini Salmonella enterica acetilovani 4 5 N terminalne acetilyuvannya Redaguvati nbsp N kinceve acetilyuvannyaN kinceve acetilyuvannya ye odniyeyu z najposhirenishih ko translyacijnih kovalentnih modifikacij aminokislot eukariotiv yaka vidigraye vazhlivu rol u regulyaciyi funkcionuvannya riznih bilkiv N kinceve acetilyuvannya viznachaye riven sintezu stabilnist ta lokalizaciyu bilkiv Blizko 85 usih bilkiv lyudini i 68 bilkiv drizhdzhiv acetilovani na yih Na kincyah 6 Kilka bilkiv prokariotiv i arheyiv takozh modifikuyutsya N kincevim acetilyuvannyam N kinceve acetilyuvannya katalizuyetsya naborom fermentnih kompleksiv N kincevih acetiltransferaz en NATi NATi perenosyat acetilnu grupu z acetil koenzimu A Ac CoA do a aminogrupi pershogo aminokislotnogo zalishku bilka Rizni NATi vidpovidayut za acetilyuvannya N kincevogo bilka aminokislotnogo lancyuga yakij sintezuyetsya Acetilyuvannya dosi vvazhalosya nezvorotnim 7 N kincevi acetiltransferazi Redaguvati Na sogodnishnij den u lyudini viyavleno shist riznih tipiv NAT NatA NatB NatC NatD NatE ta NatF Kozhen z cih riznih fermentnih kompleksiv ye specifichnim dlya riznih aminokislot abo aminokislotnih poslidovnostej yaki pokazani v nastupnij tablici Tablicya 1 Sklad ta substratna specifika NAT NAT Subodinici katalitichni subodinici vidileni zhirnim shriftom SubstratiNatA Naa10 Ard1 Naa15 Nat1 Ser Ala Gly Thr Val Cys N zakinchennyaNatB Naa20 Nat3 Naa25 Mdm20 Met Glu Met Asp Met Asn Met Gln N zakinchennyaNatC Naa30 Mak3 Naa35 Mak10 Naa38 Mak31 Met Leu Met Ile Met Trp Met Phe N zakinchennyaNatD Naa40 Nat4 Ser Gly Gly Ser Gly Arg N zakinchennyaNatE Naa50 Nat5 Naa10 Ard1 Naa15 Nat1 Met Leu Met Ala Met Lys Met Met N zakinchennyaNatF Naa60 Met Lys Met Leu Met Ile Met Trp Met Phe N zakinchennyaNatH Naa80 Aktin N zakinchennyaNatA Redaguvati Fajl NatA png alt mini 317x317pks Kristalichna struktura kompleksu NatA Naa10 i Naa15 z pompozu Schizosaccharomyces Zeleni lancyugi yavlyayut soboyu dopomizhnu subodinicyu Naa15 a cianovi lancyugi katalitichnu subodinicyu Naa10 8 Identifikator PDB 4KVM Arhivovano 26 grudnya 2019 u Wayback Machine NatA skladayetsya z dvoh subodinic katalitichnoyi subodinici Naa10 ta dopomizhnoyi subodinici Naa15 Subodinici NatA skladnishi u vishih eukariotiv u porivnyanni z nizhchimi eukariotami Naa10 Naa15 ye najposhirenishim NatA i koduyutsya genami NAA10 ta NAA15 vidpovidno Na dodatok do geniv NAA10 ta NAA15 u ssavciv ye specifichni geni NAA11 i NAA16 yakim vidpovidayut funkcionalni bilkovi produkti sho utvoryuyut rizni aktivni kompleksi NatA Ci chotiri katalitichni bilki utvoryuyut chotiri mozhlivi katalitichno dopomizhni dimeri hNatA 9 NatA acetilati Ser Ala Gly Thr Val ta Cys N kincevi pislya togo yak inicijovanij metionin vidalyayetsya metioninaminopeptidazami Ci aminokisloti chastishe ekspresuyutsya v N kincevih bilkah eukariotiv tomu NatA ye osnovnim NAT sho vidpovidaye vsij kilkosti jogo potencijnih substrativ 10 Kilka riznih partneriv po vzayemodiyi berut uchast u N kincevomu acetilyuvanni NatA Hantintin vzayemodiyuchij bilok K HYPK vzayemodiye z hNatA na ribosomi dlya vplivu na N kinceve acetilyuvannya pidmnozhini substrativ NatA Subodinici hNaa10 ta hNaa15 posilyuyut tendenciyu do agregaciyi Hantintina yaksho HYPK visnazhuyetsya Bulo takozh vstanovleno sho indukovanij gipoksiyeyu faktor HIF 1a vzayemodiye z hNaa10 shob ingibuvati aktivaciyu oposeredkovanoyi hNaa10 aktivnosti transkripciyi b kateninu 11 NatB Redaguvati Kompleksi NatB skladayutsya z katalitichnoyi subodinici Naa20p ta dopomizhnoyi subodinici Naa25p yaki ye yak u drizhdzhiv tak i u lyudini U drizhdzhiv vsi subodinici NatB pov yazani z ribosomami a u lyudini subodinici NatB viyavlyayutsya yak pov yazanimi iz ribosomoyu tak i u neribosomalnij formi NatB acetilyuye N kincevij metionin substrativ pochinayuchi z terminaliv Met Glu Met Asp Met Asn abo Met Gln N kinciv NatC Redaguvati Kompleks NatC skladayetsya z odniyeyi katalitichnoyi subodinici Naa30p ta dvoh dopomizhnih pidodinic Naa35p i Naa38p Usi tri subodinici znahodyatsya na ribosomi u drizhdzhah ale voni takozh ye u ne ribosomalnih formah NAT yak Nat2 NatC kompleks acetilyuye N kincevij metionin substrativ Met Leu Met Ile Met Trp abo Met Phe N kinciv NatD Redaguvati NatD skladayetsya lishe z katalitichnoyi odinici Naa40r yaka konceptualno vidriznyayetsya vid inshih kompleksiv NAT Spochatku bulo vidileno lishe dva substrati H2A ta H4 u drizhdzhiv ta lyudini Po druge specifichnist substratu Naa40p lezhit v mezhah pershih 30 50 zalishkiv sho znachno bilshe nizh specifichnist substratu inshih NAT Acetilyuvannya gistoniv kompleksom NatD chastkovo pov yazane z ribosomami a aminokislotni substrati ye samimi N kincevimi zalishkami sho vidriznyaye jogo vid lizinovih N acetiltransferaz KATs 12 NatE Redaguvati Kompleks NatE skladayetsya z subodinici Naa50p ta dvoh NatA subodinic Naa10p i Naa15p N kinec substrativ Naa50p vidriznyayetsya vid nih NatA acetilovanoyu aktivnistyu Naa10p 13 NatF Redaguvati nbsp NatF dimer lyudiniNatF ce NAT do skladu yakogo vhodit ferment Naa60 Spochatku vvazhalosya sho NatF viyavlenij lishe u vishih eukariotiv oskilki vin vidsutnij u drizhdzhiv 14 Odnak piznishe bulo vstanovleno sho Naa60 znahoditsya u vsomu eukariotichnomu domeni hocha vdruge vtrachayetsya u liniyi gribiv 15 Porivnyano z drizhdzhami NatF spriyaye pidvishennyu kilkosti N kincevogo acetilyuvannya u lyudini NatF kompleks acetilyuye N kincevij metionin substrativ Met Lys Met Leu Met Ile Met Trp i Met Phe N zakinchennya yaki chastkovo perekrivayutsya z NatC i NatE 6 Pokazano sho NatF lokalizuyetsya u pevnih klitinnih kompartmentah ta acetilyuye citozolni N kinci transmembrannih bilkiv 16 Kompartmentalizaciya Naa60 oposeredkovuyetsya jogo unikalnim S kincem yakij skladayetsya z dvoh alfa spiralej yaki periferichno asociyuyutsya z membranoyu i oposeredkovuyut vzayemodiyu z fosfatidilinozitol 4 fosfatom PI 4 P en 17 NAA80 NatH Redaguvati NAA80 NatH ce N kinceva acetiltransferaza yaka specifichno acetilyuye N kinec aktinu 18 N kinceva funkciya acetilyuvannya Redaguvati Stabilizaciya bilkiv Redaguvati N kinceve acetilyuvannya mozhe vplivati na stabilnist bilka ale rezultati ta mehanizm poki ostatochno nezrozumili 19 Spochatku vvazhalosya sho N kinceve acetilyuvannya zahishaye bilki vid degradaciyi oskilki Na acetilyuvannya N kinciv povinno bulo blokuvati N kincevu povsyudnist i podalshu degradaciyu bilka 20 Ale ryad doslidzhen pokazav sho N kincevij acetilovanij bilok maye shvidkist degradaciyi podibnu do bilkiv iz neblokovanim N kincem 21 Lokalizaciya bilka Redaguvati Pokazano sho N kinceve acetilyuvannya mozhe keruvati roztashuvannyam bilkiv Arl3p odna z Arf podibnih Arl GTPaz yaka maye virishalne znachennya dlya organizaciyi membrannogo ruhu 22 Na acetilyuvannya Arl3 zapushene za dopomogoyu Goldzhi membran prinalezhnogo bilka Sys1p spryamovuye transport vkazanogo bilka do membrannogo kompleksu aparatu Goldzhi Yaksho Phe abo Tyr zaminiti na Ala na N kinci Arl3p vin bilshe ne zmozhe roztashovuvatisya na membrani Goldzhi sho vkazuye na te sho Arl3p potrebuye svoyih prirodnih N kincevih zalishkiv yaki mozhut buti acetilovani dlya nalezhnoyi lokalizaciyi 23 Metabolizm ta apoptoz Redaguvati Takozh dovedeno sho bilok N kincevogo acetilyuvannya pov yazanij z regulyaciyeyu klitinnogo ciklu ta apoptozu Genetichne visnazhennya nokdaun NatA abo NatC kompleksiv prizvodit do indukciyi r53 zalezhnogo apoptozu sho mozhe svidchiti pro menshu kilkist antiapoptotichnih bilkiv abo zupinku funkcionuvannya cherez zmenshennya bilka N kincevogo acetilyuvannya 24 Prote na vidminu vid nogo kaspaza 2 acetilovana NatA mozhe vzayemodiyati z adapternim bilkom RIP pov yazanim iz Ich 1 Ced 3 gomologichnimi bilkami zi smertyu domen RAIDD Ce mozhe aktivuvati kaspazu 2 i indukuye klitinnij apoptoz 25 Sintez bilka Redaguvati Ribosomi bilkiv vidigrayut vazhlivu rol v procesi sintezu bilka yakij mozhe buti acetilovanim na N kinci N kinceve acetilyuvannya bilkiv ribosomi mozhe vplivati na sintez bilka Znizhennya na 27 i 23 u shvidkosti sintezu bilka sposterigalosya z NatA i NatB shtamiv vidalennya Znizhennya tochnosti translyaciyi sposterigalasya u NatA deformaciyi vidalennya i defekt v ribosomi buv pomichenij u NatB deformaciyi vidalennya 26 Rak Redaguvati Zaproponovano sho NATi mozhut vistupati yak onko bilki i puhlinni supresori pri zahvoryuvannyah lyudej na rak i ekspresiya NAT mozhe yak zbilshuvati tak i zmenshuvati rakovi klitini Ektopichna ekspresiya hNaa10p pidvishenoyi proliferaciyi klitin en ta regulyaciyi geniv sho berut uchast v klitinnoyi proliferaciyi ta vizhivannya obminu rechovin Nadmirna ekspresiya hNaa10p sposterigalasya pri raku sechovogo mihura raku molochnoyi zalozi ta raku shijki matki 27 Ale ekspresiya visokogo rivnya hNaa10p takozh mozhe prignichuvati rist puhlini i znizhenij riven hNaa10p pov yazanij z poganimi prognozami velikimi puhlinami i metastazami u limfovuzlah Tablicya 2 Oglyad virazhennya NatA subodinic v riznih rakovih tkaninah 28 Subodinici Nat Rakovi tkanini Shablon virazhennyahNaa10 raku legeniv raku molochnoyi zalozi kolorektalnogo raku gepatocelyulyarnoyi karcinomi visoko v puhlinihNaa10 rak legeniv rak molochnoyi zalozi rak pidshlunkovoyi zalozi rak yayechnikiv vtrata geterozigotnosti v puhlinihNaa10 rak molochnoyi zalozi rak shlunka rak legeniv visoko v pervinnoyi puhlini ale nizka metastazi v limfovuzli hNaa10 Nemilkoklitinna karcinoma legeni en nizka pri puhlinahhNaa15 papilyarnij rak shitopodibnoyi zalozi rak shlunka visoko v puhlinihNaa15 nejroblastoma visoko v prosunutij stadiyi puhlinihNaa11 gepatocelyulyarna karcinoma vtrata geterozigotnosti v puhliniAcetilyuvannya i deacetilyuvannya lizinu Redaguvati nbsp Acetiluvannya lizinuBilki zazvichaj acetilovani na zalishkah lizinu i cya reakciya pokladayetsya na acetil koenzim A yak donora acetilnoyi grupi U procesi acetiluvannya i deacetilyuvannya gistoniv en gistonovi bilki acetilovani i deacetilovani na lizinovih zalishkah N kincevij hvist yak chastina gennoyi regulyaciyi Zazvichaj ci reakciyi katalizuyutsya fermentami z aktivnistyu acetiltransferazi gistoniv HAT abo gistondeacetilazi deacetilazah gistoniv hocha NATi i HDACi mozhut takozh zminyuvati status acetilyuvannya negistonovih bilkiv 29 Regulyaciya faktoriv transkripciyi efektornih bilkiv molekulyarnih shaperoniv ta citoskeletnih bilkiv shlyahom acetilyuvannya i deacetilirovaniya ye istotnim pislya translyacijnim regulyatornim mehanizmom 30 Ci regulyatorni mehanizmi analogichni do fosforilyuvannya i defosforilyuvannya pid diyeyu kinaz i fosfataz Ne tilki stan acetilyuvannya bilka mozhe zminyuvati jogo aktivnist ale ostannim chasom pripuskayetsya sho cya post translyacijna modifikaciya mozhe takozh nadati perehresni perevagi dlya fosforilyuvannya metilyuvannya ubikvitinuvannya sumoyilyaciyeyu ta inshi dlya dinamichnogo kontrolyu klitinnoyi signalizaciyi 31 Prikladom cogo ye regulyuvannya bilka tubulinu v nejronah mishej i astrogliyi 32 33 Tubulinova acetiltransferaza roztashovana v aksonemi i acetilyuye v a tubulinovu subodinicyu v zibranij mikrotrubochci Pislya togo yak odin raz rozibrano ce acetilyuvannya vidalyayetsya inshoyu specifichnoyu deacetilazoyu v citozoli klitini Takim chinom aksonemalni mikrotrubochki yaki mayut trivalij period napivvivedennya zdijsnyuyut pidpisne acetilyuvannya yake vidsutnye u citozolnih mikrotrubochkah yaki mayut korotshij period napivvivedennya U galuzi epigenetiki pokazano sho acetilyuvannya gistonu i deacetilyuvannya ye vazhlivimi mehanizmami regulyaciyi transkripciyi geniv Odnak gistoni ne ye yedinimi bilkami regulovanimi posttranslyacijnim acetilyuvannyam Dali navedeno prikladi riznih inshih bilkiv yaki mayut rol u regulyaciyi peretvorennya signalu na diyalnist yakih takozh vplivaye acetilyuvannya ta deacetilyuvannya p53 Redaguvati Bilok p53 ce puhlinnij supresor yakij vidigraye vazhlivu rol u signalnih tranzakciyah u klitinah osoblivo u pidtrimci stabilnosti genomu shlyahom zapobigannya mutaciyi Tomu vin takozh vidomij yak ohoronec genomu Vin takozh regulyuye klitinnij cikl i zatrimuye rist klitin aktivuyuchi regulyator klitinnogo ciklu p21 Pri silnomu poshkodzhenni DNK vin takozh iniciyuye programu zagibeli klitini Funkciya p53 negativno regulyuyetsya onkobilkom Mdm2 Doslidzhennya pripuskali sho Mdm2 formuvatime kompleks z p53 i ne dozvolyaye jomu zv yazuvatisya z pevnimi genami chutlivimi do p53 34 35 Acetilyuvannya r53 Redaguvati nbsp sajt acetilyuvannya p53Acetilyuvannya r53 nezaminne dlya jogo aktivaciyi Povidomlyalosya sho riven acetilyuvannya p53 znachno zrostaye koli klitina zaznaye stresu Na p53 ye tri osnovni miscya acetilyuvannya K164 K120 i C kinec 36 Yaksho lishe odna z dilyanok acetilyuvannya defektovana aktivaciya p21 vse she sposterigayetsya Odnak yaksho vsi tri sajti aktivaciyi zablokovani aktivaciya p21 ta pridushennya rostu klitin viklikane p53 budut povnistyu vtracheni Krim togo acetilyuvannya p53 pereshkodzhaye jogo zv yazuvannyu z represorom Mdm2 na DNK 37 Takozh peredbachayetsya sho acetilyuvannya p53 maye virishalne znachennya dlya proapoptotichnih funkcij nezalezhnih vid transkripciyi 38 Naslidki dlya terapiyi raku Redaguvati Oskilki osnovna funkciya p53 ce supresor puhlini ideya pro te sho aktivaciya p53 ye privablivoyu strategiyeyu likuvannya raku Nutlin 3 39 ce nevelika molekula priznachena dlya nacilyuvannya na vzayemodiyu p53 ta Mdm2 yaka utrimuvala p53 vid dezaktivaciyi 40 Zviti takozh pokazali sho rakova klitina pid chas likuvannya Nutilin 3a acetilyuvannya lys 382 sposterigalasya v c kinci bilka p53 41 42 Mikrotrubochka Redaguvati nbsp Utvorennya mikrotrubochkiStruktura mikrotrubochok ce dovgij porozhnistij cilindr yakij dinamichno zibranij iz dimeriv a b tubulinu Voni vidigrayut vazhlivu rol u pidtrimci strukturi klitini a takozh klitinnih procesah napriklad ruhu organel 43 Krim togo mikrotrubochka vidpovidaye za formuvannya mitotichnogo veretena v eukariotichnih klitinah dlya transportuvannya hromosom pri podili klitin 44 45 Acetilyuvannya tubulinu Redaguvati nbsp Acetilyuvannya tubulinuAcetilovanij zalishok a tubulinu K40 yakij u lyudini katalizuyetsya a tubulin acetil transferazoyu a TAT Acetilyuvannya K40 na a tubulin ye oznakoyu stabilnih mikrotrubochok Zalishki aktivnoyi dilyanki D157 ta C120 a TAT1 vidpovidayut za kataliz cherez formu sho dopovnyuye a tubulin Krim togo deyaki unikalni strukturni osoblivosti taki yak shpilka b4 b5 dilyanka S kincevogo ciklu ta dilyanki petli a1 a2 vazhlivi dlya specifichnogo rozpiznavannya a tubulinu 46 Zvorotna reakciya acetilyuvannya katalizuyetsya gistondeacetilazoyu 6 47 Naslidki dlya terapiyi raku Redaguvati Oskilki mikrotrubochki vidigrayut vazhlivu rol u podili klitin osoblivo u fazi G2 M klitinnogo ciklu buli zrobleni sprobi unemozhliviti funkcionuvannya mikrotrubochok za dopomogoyu ingibitoriv malih molekul yaki uspishno vikoristovuyutsya v klinikah yak terapiya raku 48 Napriklad alkaloyidi vinka ta taksani selektivno zv yazuyutsya i ingibuyut mikrotrubochki sho prizvodit do zupinki klitinnogo ciklu 49 Identifikaciya kristalichnoyi strukturi acetilyuvannya a tubulin acetil transferazi a TAT takozh prolivaye svitlo na viyavlennya nevelikoyi molekuli yaka mogla b modulyuvati stabilnist abo depolimerizaciyu tubulinu Inshimi slovami oriyentuyuchis na a TAT mozhna zapobigti acetilyuvannyu tubulinu i prizvesti do destabilizaciyi tubulinu sho ye analogichnim mehanizmom destabilizuyuchih agentiv tubulinu 46 STAT3 Redaguvati Peretvoryuvach signalu ta aktivator transkripciyi 3 STAT3 vid angl Signal Transducer and Activator of Transcription 3 ce faktor transkripciyi yakij fosforilyuyetsya kinazami pov yazanimi z receptorami napriklad tirozinkinazi simejstva Yanusa i perehodit u yadro STAT3 regulyuye dekilka geniv u vidpovid na faktori rostu ta citokini ta vidigrayut vazhlivu rol u rist klitin Tomu STAT3 polegshuye onkogenez u riznih shlyahah pov yazanih iz rostom klitin Z inshogo boku vin takozh vidigraye rol v supresori puhlini 50 Acetilyuvannya STAT3 Redaguvati nbsp Struktura ta acetilyuvannya zalishku STAT3Acetilyuvannya Lys685 STAT3 maye vazhlive znachennya dlya STAT3 gomo dimerizaciyi sho maye vazhlive znachennya dlya DNK zv yazuvannya ta transkripcijnoyi aktivaciyi onkogeniv Acetilyuvannya STAT3 katalizuyetsya giston acetiltransferazoyu p300 i reversuyetsya za dopomogoyu histondeacetilazi tipu 1 Acetilyuvannya lizinu STAT3 takozh pidvisheno v rakovih klitinah 51 Terapevtichni naslidki dlya terapiyi raku Redaguvati Oskilki acetilyuvannya STAT3 vazhlive dlya jogo onkogennoyi aktivnosti ta togo sho riven acetilovanogo STAT3 visokij u rakovih klitinah mayetsya na uvazi sho oriyentaciya na acetilovanij STAT3 dlya himioprofilaktiki ta himioterapiyi ye perspektivnoyu strategiyeyu Cya strategiya pidtrimuyetsya shlyahom likuvannya resveratrolu ingibitora acetilyuvannya STAT3 u rakovij klitinnij liniyi obertayetsya vidhilene metilyuvannya ostrova CpG 52 Acetilyuvannya derevini RedaguvatiZ pochatku 20 stolittya acetilyuvannya derevini doslidzhuvalosya yak metod pidvishennya micnosti derevini v stijkosti do procesiv gnittya ta cvili Do vtorinnih perevag mozhna vidnesti pokrashennya stabilnosti rozmiriv polipshenu tverdist poverhni ta vidsutnist znizhennya mehanichnih vlastivostej zavdyaki obrobci Fizichni vlastivosti bud yakogo materialu viznachayutsya jogo himichnoyu budovoyu Derevina mistit veliku kilkist himichnih grup yaki nazivayutsya vilni gidroksili Vilni gidroksilni grupi adsorbuyut i vidilyayut vodu vidpovidno do zmin klimatichnih umov yakim piddayetsya derevina Ce poyasnennya togo chomu derevina nabuhaye ta usadzhuyetsya Vvazhayetsya takozh sho peretravlennya derevini fermentami iniciyuyetsya na vilnih dilyankah gidroksilu sho ye odniyeyu z golovnih prichin chomu derevina shilna do gnittya Acetilyuvannya zminyuye vilni gidroksili vseredini derevini na acetilni grupi Ce robitsya shlyahom vzayemodiyi derevini z octovim angidridom yakij pohodit z octovoyi kisloti vidomij yak ocet koli vin znahoditsya v rozvedenomu viglyadi Koli vilna gidroksilna grupa peretvoryuyetsya na acetilnu grupu zdatnist derevini poglinati vodu silno znizhuyetsya roblyachi derevinu stabilnoyu za linijnimi parametrami i oskilki vona vzhe ne 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