MAPT angl Microtubule associated protein tau bilok yakij koduyetsya odnojmennim genom roztashovanim u lyudej na korotkomu plechi 17 yi hromosomi 4 Dovzhina polipeptidnogo lancyuga bilka stanovit 758 aminokislot a molekulyarna masa 78 928 5 MAPTNayavni strukturiPDBPoshuk ortologiv PDBe RCSBSpisok kodiv PDB1I8H 4GLR 2ON9 3OVL 4E0M 4E0N 4E0O 4FL5 4NP8 2MZ7 4TQE 4Y5I 4Y32 5DMG 4Y3B 5HF3 5E2W 5E2VIdentifikatoriSimvoliMAPT DDPAC FTDP 17 MAPTL MSTD MTBT1 MTBT2 PPND PPP1R103 TAU microtubule associated protein tau Tau proteins tau 40Zovnishni ID OMIM 157140 MGI 97180 HomoloGene 74962 GeneCards MAPTPov yazani genetichni zahvoryuvannyainterstitial lung disease progressive supranuclear palsy hvoroba Parkinsona Hvoroba Pika semantic dementia 1 Ontologiya genaMolekulyarna funkciya apolipoprotein binding SH3 domain binding tubulin binding GO 0001948 GO 0016582 protein binding lipoprotein particle binding enzyme binding DNA binding actin binding microtubule binding dynactin binding receptor ligand activity protein phosphatase 2A binding Hsp90 protein binding minor groove of adenine thymine rich DNA binding double stranded DNA binding single stranded DNA binding RNA binding protein kinase binding protein macromolecule adaptor activity phosphatidylinositol binding identical protein binding protein homodimerization activity sequence specific DNA binding chaperone binding histone dependent DNA binding microtubule lateral binding phosphatidylinositol bisphosphate bindingKlitinna komponenta citoplazma cell body cell projection nuclear periphery growth cone neurofibrillary tangle klitinna membrana tubulin complex Dendrit nejrobiologiya cytoplasmic ribonucleoprotein granule Citoskelet klitinne yadro gialoplazma Mikrotrubochki microtubule associated complex membrana nuclear speck Akson somatodendritic compartment neuronal cell body axon cytoplasm extracellular region vnutrishnoklitinnij mitohondriya microtubule cytoskeleton axolemma neuron projection dendritic spine main axon membrane raft glial cell projectionBiologichnij proces generation of neurons regulation of autophagy regulation of microtubule polymerization positive regulation of microtubule polymerization positive regulation of axon extension microtubule cytoskeleton organization microglial cell activation activation of cysteine type endopeptidase activity involved in apoptotic process GO 0072468 Signalna transdukciya pam yat negative regulation of mitochondrial membrane potential axonal transport of mitochondrion cytoplasmic microtubule organization neuron projection development positive regulation of superoxide anion generation negative regulation of kinase activity cellular response to heat astrocyte activation intracellular distribution of mitochondria synapse organization regulation of calcium mediated signaling protein complex oligomerization plus end directed organelle transport along microtubule regulation of mitochondrial fission negative regulation of mitochondrial fission Aksoplazmatichnij transport regulation of cellular response to heat positive regulation of neuron death positive regulation of protein localization to synapse neurofibrillary tangle assembly negative regulation of establishment of protein localization to mitochondrion positive regulation of diacylglycerol kinase activity regulation of response to DNA damage stimulus internal protein amino acid acetylation cell cell signaling response to lead ion regulation of signaling receptor activity negative regulation of gene expression rRNA metabolic process central nervous system neuron development regulation of microtubule polymerization or depolymerization regulation of chromosome organization stress granule assembly GO 0072353 cellular response to reactive oxygen species microtubule polymerization regulation of synaptic plasticity axon development regulation of microtubule cytoskeleton organization supramolecular fiber organization regulation of long term synaptic depression positive regulation of protein localization negative regulation of tubulin deacetylation amyloid fibril formation cellular response to nerve growth factor stimulus cellular response to brain derived neurotrophic factor stimulusDzherela Amigo QuickGOShablon ekspresiyiBilshe danihOrtologiVidi Lyudina MishaEntrez4137 17762Ensembl ENSG00000186868ENSG00000276155ENSG00000277956 ENSMUSG00000018411UniProt P10636 P10637RefSeq mRNK NM 001123066NM 001123067NM 001203251NM 001203252NM 005910NM 016834NM 016835NM 016841NM 001377265NM 001377266NM 001377267NM 001377268NM 001038609NM 010838NM 001285454NM 001285455NM 001285456RefSeq bilok NP 001116538NP 001116539NP 001190180NP 001190181NP 005901NP 058518NP 058519NP 058525NP 001364194NP 001364195NP 001364196NP 001364197NP 001033698NP 001272383NP 001272384NP 001272385NP 034968NP 001390904NP 001390905NP 001390906NP 001390907NP 001390908NP 001390909NP 001390910NP 001390911NP 001390912NP 001390913NP 001390916NP 001390919NP 001390921NP 001390923NP 001390925NP 001390927NP 001390928NP 001390931NP 001390933NP 001390934NP 001390935NP 001390939NP 001390940NP 001390941NP 001390943NP 001390944NP 001390945Lokus UCSC Hr 17 45 89 46 03 MbHr 11 104 23 104 33 MbPubMed search 2 3 VikidaniDiv Red dlya lyudejDiv Red dlya mishej Poslidovnist aminokislot1020304050MAEPRQEFEVMEDHAGTYGLGDRKDQGGYTMHQDQEGDTDAGLKESPLQTPTEDGSEEPGSETSDAKSTPTAEDVTAPLVDEGAPGKQAAAQPHTEIPEGTTAEEAGIGDTPSLEDEAAGHVTQEPESGKVVQEGFLREPGPPGLSHQLMSGMPGAPLLPEGPREATRQPSGTGPEDTEGGRHAPELLKHQLLGDLHQEGPPLKGAGGKERPGSKEEVDEDRDVDESSPQDSPPSKASPAQDGRPPQTAAREATSIPGFPAEGAIPLPVDFLSKVSTEIPASEPDGPSVGRAKGQDAPLEFTFHVEITPNVQKEQAHSEEHLGRAAFPGAPGEGPEARGPSLGEDTKEADLPEPSEKQPAAAPRGKPVSRVPQLKARMVSKSKDGTGSDDKKAKTSTRSSAKTLKNRPCLSPKHPTPGSSDPLIQPSSPAVCPEPPSSPKYVSSVTSRTGSSGAKEMKLKGADGKTKIATPRGAAPPGQKGQANATRIPAKTPPAPKTPPSSGEPPKSGDRSGYSSPGSPGTPGSRSRTPSLPTPPTREPKKVAVVRTPPKSPSSAKSRLQTAPVPMPDLKNVKSKIGSTENLKHQPGGGKVQIINKKLDLSNVQSKCGSKDNIKHVPGGGSVQIVYKPVDLSKVTSKCGSLGNIHHKPGGGQVEVKSEKLDFKDRVQSKIGSLDNITHVPGGGNKKIETHKLTFRENAKAKTDHGAEIVYKSPVVSGDTSPRHLSNVSSTGSIDMVDSPQLATLADEVSASLAKQGLA Alanin C Cisteyin D Asparaginova kislota E Glutaminova kislota F Fenilalanin G Glicin H Gistidin I Izolejcin K Lizin L Lejcin M Metionin N Asparagin P Prolin Q Glutamin R Arginin S Serin T Treonin V Valin Y Tirozin Kodovanij genom bilok za funkciyeyu nalezhit do fosfoproteyiniv Zadiyanij u takih biologichnih procesah yak acetilyuvannya alternativnij splajsing Lokalizovanij u klitinnij membrani citoplazmi citoskeleti membrani klitinnih vidrostkah Literatura RedaguvatiGoedert M Wischik C Crowther R Walker J Klug A 1988 Cloning and sequencing of the cDNA encoding a core protein of the paired helical filament of Alzheimer disease identification as the microtubule associated protein tau Proc Natl Acad Sci U S A 85 4051 4055 PubMed DOI 10 1073 pnas 85 11 4051 Lee G Neve R L Kosik K S 1989 The microtubule binding domain of tau protein Neuron 2 1615 1624 PubMed DOI 10 1016 0896 6273 89 90050 0 Goedert M Spillantini M G Jakes R Rutherford D Crowther R A 1989 Multiple isoforms of human microtubule associated protein tau sequences and localization in neurofibrillary tangles of Alzheimer s disease Neuron 3 519 526 PubMed DOI 10 1016 0896 6273 89 90210 9 Andreadis A Brown W M Kosik K S 1992 Structure and novel exons of the human tau gene Biochemistry 31 10626 10633 PubMed DOI 10 1021 bi00158a027 The status quality and expansion of the NIH full length cDNA project the Mammalian Gene Collection MGC Genome Res 14 2121 2127 2004 PubMed DOI 10 1101 gr 2596504 Lee V M Balin B J Otvos L Jr Trojanowski J Q 1991 A68 a major subunit of paired helical filaments and derivatized forms of normal Tau Science 251 675 678 PubMed DOI 10 1126 science 1899488Primitki Redaguvati Zahvoryuvannya genetichno pov yazani z MAPT pereglyanuti redaguvati posilannya na VikiDanih Human PubMed Reference Mouse PubMed Reference HUGO Gene Nomenclature Commitee HGNC 6893 angl Arhiv originalu za 6 travnya 2017 Procitovano 12 veresnya 2017 UniProt P10636 angl Arhiv originalu za 17 veresnya 2017 Procitovano 12 veresnya 2017 Div takozh RedaguvatiHromosoma 17 nbsp Ce nezavershena stattya pro bilki Vi mozhete dopomogti proyektu vipravivshi abo dopisavshi yiyi Otrimano z https uk wikipedia org w index php title MAPT amp oldid 35658837
