RUNX1 angl Runt related transcription factor 1 bilok yakij koduyetsya odnojmennim genom roztashovanim u lyudej na korotkomu plechi 21 yi hromosomi 4 Dovzhina polipeptidnogo lancyuga bilka stanovit 453 aminokislot a molekulyarna masa 48 737 5 RUNX1Nayavni strukturiPDBPoshuk ortologiv PDBe RCSBSpisok kodiv PDB1CMO 1CO1 1E50 1H9D 1LJMIdentifikatoriSimvoliRUNX1 AML1 AML1 EVI 1 AMLCR1 CBF2alpha CBFA2 EVI 1 PEBP2aB PEBP2alpha runt related transcription factor 1 RUNX family transcription factor 1Zovnishni ID OMIM 151385 MGI 99852 HomoloGene 1331 GeneCards RUNX1Pov yazani genetichni zahvoryuvannyanaturalna vispa rak stravohodu hereditary thrombocytopenia with normal platelets hematological cancer predisposition syndrome gostrij miyeloyidnij lejkoz 1 Ontologiya genaMolekulyarna funkciya DNA binding calcium ion binding RNA polymerase II transcription regulatory region sequence specific DNA binding protein homodimerization activity GO 0001131 GO 0001151 GO 0001130 GO 0001204 DNA binding transcription factor activity GO 0001077 GO 0001212 GO 0001213 GO 0001211 GO 0001205 DNA binding transcription activator activity RNA polymerase II specific transcription factor binding GO 0001948 GO 0016582 protein binding protein heterodimerization activity ATP binding GO 0001200 GO 0001133 GO 0001201 DNA binding transcription factor activity RNA polymerase II specific GO 0000980 RNA polymerase II cis regulatory region sequence specific DNA bindingKlitinna komponenta vnutrishnoklitinna membranna organela klitinne yadro gialoplazma Nukleoplazma core binding factor complexBiologichnij proces peripheral nervous system neuron development myeloid cell differentiation GO 0009373 regulation of transcription DNA templated chondrocyte differentiation Osifikaciya negative regulation of granulocyte differentiation hematopoietic stem cell proliferation transcription DNA templated positive regulation of angiogenesis GO 0060469 GO 0009371 positive regulation of transcription DNA templated positive regulation of interleukin 2 production positive regulation of granulocyte differentiation GO 0003257 GO 0010735 GO 1901228 GO 1900622 GO 1904488 positive regulation of transcription by RNA polymerase II transcription by RNA polymerase II regulation of cytokine mediated signaling pathway regulation of Wnt signaling pathway regulation of intracellular estrogen receptor signaling pathway regulation of regulatory T cell differentiation regulation of keratinocyte differentiation regulation of myeloid cell differentiation regulation of megakaryocyte differentiation regulation of B cell receptor signaling pathway regulation of hematopoietic stem cell differentiation regulation of bicellular tight junction assembly krovotvorennya GO 1901227 negative regulation of transcription by RNA polymerase II negative regulation of CD4 positive alpha beta T cell differentiation positive regulation of CD8 positive alpha beta T cell differentiation negative regulation of gene expression neuron differentiationDzherela Amigo QuickGOShablon ekspresiyiBilshe danihOrtologiVidi Lyudina MishaEntrez861 12394Ensembl ENSG00000159216 ENSMUSG00000022952UniProt Q01196 Q03347RefSeq mRNK NM 001001890NM 001122607NM 001754NM 001111021NM 001111022NM 001111023NM 009821RefSeq bilok NP 001001890NP 001116079NP 001745n dLokus UCSC Hr 21 34 79 36 MbHr 16 92 4 92 62 MbPubMed search 2 3 VikidaniDiv Red dlya lyudejDiv Red dlya mishej Poslidovnist aminokislot1020304050MRIPVDASTSRRFTPPSTALSPGKMSEALPLGAPDAGAALAGKLRSGDRSMVEVLADHPGELVRTDSPNFLCSVLPTHWRCNKTLPIAFKVVALGDVPDGTLVTVMAGNDENYSAELRNATAAMKNQVARFNDLRFVGRSGRGKSFTLTITVFTNPPQVATYHRAIKITVDGPREPRRHRQKLDDQTKPGSLSFSERLSELEQLRRTAMRVSPHHPAPTPNPRASLNHSTAFNPQPQSQMQDTRQIQPSPPWSYDQSYQYLGSIASPSVHPATPISPGRASGMTTLSAELSSRLSTAPDLTAFSDPRQFPALPSISDPRMHYPGAFTYSPTPVTSGIGIGMSAMGSATRYHTYLPPPYPGSSQAQGGPFQASSPSYHLYYGASAGSYQFSMVGGERSPPRILPPCTNASTGSALLNPSLPNQSDVVEAEGSHSNSPTNMAPSARLEEAVWRPYA Alanin C Cisteyin D Asparaginova kislota E Glutaminova kislota F Fenilalanin G Glicin H Gistidin I Izolejcin K Lizin L Lejcin M Metionin N Asparagin P Prolin Q Glutamin R Arginin S Serin T Treonin V Valin W Triptofan Y Tirozin Kodovanij genom bilok za funkciyami nalezhit do represoriv aktivatoriv fosfoproteyiniv Zadiyanij u takih biologichnih procesah yak transkripciya regulyaciya transkripciyi acetilyuvannya alternativnij splajsing Bilok maye sajt dlya zv yazuvannya z DNK hloridom Lokalizovanij u yadri Literatura red Meyers S Lenny N Hiebert S W 1995 The t 8 21 fusion protein interferes with AML 1B dependent transcriptional activation Mol Cell Biol 15 1974 1982 PubMed DOI 10 1128 MCB 15 4 1974 The status quality and expansion of the NIH full length cDNA project the Mammalian Gene Collection MGC Genome Res 14 2121 2127 2004 PubMed DOI 10 1101 gr 2596504 Ghozi M C Bernstein Y Negreanu V Levanon D Groner Y 1996 Expression of the human acute myeloid leukemia gene AML1 is regulated by two promoter regions Proc Natl Acad Sci U S A 93 1935 1940 PubMed DOI 10 1073 pnas 93 5 1935 Daga A Tighe J E Calabi F 1992 Leukaemia Drosophila homology Nature 356 484 484 PubMed DOI 10 1038 356484b0 Meyers S Downing J R Hiebert S W 1993 Identification of AML 1 and the 8 21 translocation protein AML 1 ETO as sequence specific DNA binding proteins the runt homology domain is required for DNA binding and protein protein interactions Mol Cell Biol 13 6336 6345 PubMed DOI 10 1128 MCB 13 10 6336 Bruhn L Munnerlyn A Grosschedl R 1997 ALY a context dependent coactivator of LEF 1 and AML 1 is required for TCRalpha enhancer function Genes Dev 11 640 653 PubMed DOI 10 1101 gad 11 5 640Primitki red Zahvoryuvannya genetichno pov yazani z RUNX1 pereglyanuti redaguvati posilannya na VikiDanih Human PubMed Reference Mouse PubMed Reference HUGO Gene Nomenclature Commitee HGNC 10471 angl Arhiv originalu za 10 travnya 2017 Procitovano 12 veresnya 2017 UniProt Q01196 angl Arhiv originalu za 11 veresnya 2017 Procitovano 12 veresnya 2017 Div takozh red Hromosoma 21 nbsp Ce nezavershena stattya pro bilki Vi mozhete dopomogti proyektu vipravivshi abo dopisavshi yiyi Otrimano z https uk wikipedia org w index php title RUNX1 amp oldid 35715392
