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ARFGEF2 англ ADP ribosylation factor guanine nucleotide exchange factor 2 білок який кодується однойменним геном розташо

ARFGEF2

ARFGEF2 (англ. ADP ribosylation factor guanine nucleotide exchange factor 2) – білок, який кодується однойменним геном, розташованим у людей на короткому плечі 20-ї хромосоми. Довжина поліпептидного ланцюга білка становить 1 785 амінокислот, а молекулярна маса — 202 038.

ARFGEF2
Наявні структури
PDBПошук ортологів: PDBe RCSB
Ідентифікатори
Символи ARFGEF2, BIG2, PVNH2, dJ1164I10.1, ADP ribosylation factor guanine nucleotide exchange factor 2
Зовнішні ІД OMIM: 605371 MGI: 2139354 HomoloGene: 111880 GeneCards: ARFGEF2
Шаблон експресії


Більше даних
Ортологи
Види Людина Миша
Entrez
10564
99371
Ensembl
UniProt
RefSeq (мРНК)
RefSeq (білок)
Локус (UCSC) Хр. 20: 48.92 – 49.04 Mb Хр. 2: 166.65 – 166.74 Mb
PubMed search
Вікідані
Див./Ред. для людейДив./Ред. для мишей
Послідовність амінокислот
1020304050
MQESQTKSMFVSRALEKILADKEVKRPQHSQLRRACQVALDEIKAEIEKQ
RLGTAAPPKANFIEADKYFLPFELACQSKSPRVVSTSLDCLQKLIAYGHI
TGNAPDSGAPGKRLIDRIVETICSCFQGPQTDEGVQLQIIKALLTAVTSP
HIEIHEGTILQTVRTCYNIYLASKNLINQTTAKATLTQMLNVIFTRMENQ
VLQEARELEKPIQSKPQSPVIQAAAVSPKFVRLKHSQAQSKPTTPEKTDL
TNGEHARSDSGKVSTENGDAPRERGSSLSGTDDGAQEVVKDILEDVVTSA
IKEAAEKHGLTEPERVLGELECQECAIPPGVDENSQTNGIADDRQSLSSA
DNLESDAQGHQVAARFSHVLQKDAFLVFRSLCKLSMKPLGEGPPDPKSHE
LRSKVVSLQLLLSVLQNAGPVFRTHEMFINAIKQYLCVALSKNGVSSVPD
VFELSLAIFLTLLSNFKMHLKMQIEVFFKEIFLNILETSTSSFEHRWMVI
QTLTRICADAQCVVDIYVNYDCDLNAANIFERLVNDLSKIAQGRSGHELG
MTPLQELSLRKKGLECLVSILKCMVEWSKDLYVNPNHQTSLGQERLTDQE
IGDGKGLDMARRCSVTSMESTVSSGTQTTVQDDPEQFEVIKQQKEIIEHG
IELFNKKPKRGIQFLQEQGMLGTSVEDIAQFLHQEERLDSTQVGDFLGDS
ARFNKEVMYAYVDQLDFCEKEFVSALRTFLEGFRLPGEAQKIDRLMEKFA
ARYIECNQGQTLFASADTAYVLAYSIIMLTTDLHSPQVKNKMTKEQYIKM
NRGINDSKDLPEEYLSSIYEEIEGKKIAMKETKELTIATKSTKQNVASEK
QRRLLYNLEMEQMAKTAKALMEAVSHAKAPFTSATHLDHVRPMFKLVWTP
LLAAYSIGLQNCDDTEVASLCLEGIRCAIRIACIFGMQLERDAYVQALAR
FSLLTASSSITEMKQKNIDTIKTLITVAHTDGNYLGNSWHEILKCISQLE
LAQLIGTGVKTRYLSGSGREREGSLKGHTLAGEEFMGLGLGNLVSGGVDK
RQMASFQESVGETSSQSVVVAVDRIFTGSTRLDGNAIVDFVRWLCAVSMD
ELASPHHPRMFSLQKIVEISYYNMNRIRLQWSRIWHVIGDHFNKVGCNPN
EDVAIFAVDSLRQLSMKFLEKGELANFRFQKDFLRPFEHIMKKNRSPTIR
DMAIRCIAQMVNSQAANIRSGWKNIFAVFHQAASDHDGNIVELAFQTTCH
IVTTIFQHHFPAAIDSFQDAVKCLSEFACNAAFPDTSMEAIRLIRFCGKY
VSERPRVLQEYTSDDMNVAPGDRVWVRGWFPILFELSCIINRCKLDVRTR
GLTVMFEIMKSYGHTFEKHWWQDLFRIVFRIFDNMKLPEQLSEKSEWMTT
TCNHALYAICDVFTQFYEALNEVLLSDVFAQLQWCVKQDNEQLARSGTNC
LENLVISNGEKFSPEVWDETCNCMLDIFKTTIPHVLLTWRPVGMEEDSSE
KHLDVDLDRQSLSSIDKNPSERGQSQLSNPTDDSWKGRPYANQKLFASLL
IKCVVQLELIQTIDNIVFYPATSKKEDAEHMVAAQQDTLDADIHIETEDQ
GMYKYMSSQHLFKLLDCLQESHSFSKAFNSNYEQRTVLWRAGFKGKSKPN
LLKQETSSLACCLRILFRMYVDENRRDSWEEIQQRLLTVCSEALAYFITV
NSESHREAWTSLLLLLLTKTLKINDEKFKAHASMYYPYLCEIMQFDLIPE
LRAVLRKFFLRIGVVYKIWIPEEPSQVPAALSPVW

Кодований геном білок за функцією належить до фосфопротеїнів. Задіяний у таких біологічних процесах, як транспорт, транспорт білків, ацетилювання. Локалізований у цитоплазмі, цитоскелеті, мембрані, клітинних контактах, клітинних відростках, цитоплазматичних везикулах, апараті гольджі, синапсах, ендосомах.

Література ред.

  • Togawa A., Morinaga N., Ogasawara M., Moss J., Vaughan M. (1999). Purification and cloning of a brefeldin A-inhibited guanine nucleotide-exchange protein for ADP-ribosylation factors.. J. Biol. Chem. 274: 12308 — 12315.  PubMed DOI:10.1074/jbc.274.18.12308
  • Shinotsuka C., Waguri S., Wakasugi M., Uchiyama Y., Nakayama K. (2002). Dominant-negative mutant of BIG2, an ARF-guanine nucleotide exchange factor, specifically affects membrane trafficking from the trans-Golgi network through inhibiting membrane association of AP-1 and GGA coat proteins.. Biochem. Biophys. Res. Commun. 294: 254 — 260.  PubMed DOI:10.1016/S0006-291X(02)00456-4
  • Li H., Adamik R., Pacheco-Rodriguez G., Moss J., Vaughan M. (2003). Protein kinase A-anchoring (AKAP) domains in brefeldin A-inhibited guanine nucleotide-exchange protein 2 (BIG2).. Proc. Natl. Acad. Sci. U.S.A. 100: 1627 — 1632.  PubMed DOI:10.1073/pnas.0337678100
  • Shin H.W., Morinaga N., Noda M., Nakayama K. (2004). BIG2, a guanine nucleotide exchange factor for ADP-ribosylation factors: its localization to recycling endosomes and implication in the endosome integrity.. Mol. Biol. Cell 15: 5283 — 5294.  PubMed DOI:10.1091/mbc.E04-05-0388
  • Ishizaki R., Shin H.W., Iguchi-Ariga S.M., Ariga H., Nakayama K. (2006). AMY-1 (associate of Myc-1) localization to the trans-Golgi network through interacting with BIG2, a guanine-nucleotide exchange factor for ADP-ribosylation factors.. Genes Cells 11: 949 — 959.  PubMed DOI:10.1111/j.1365-2443.2006.00991.x
  • Kuroda F., Moss J., Vaughan M. (2007). Regulation of brefeldin A-inhibited guanine nucleotide-exchange protein 1 (BIG1) and BIG2 activity via PKA and protein phosphatase 1gamma.. Proc. Natl. Acad. Sci. U.S.A. 104: 3201 — 3206.  PubMed DOI:10.1073/pnas.0611696104

Примітки ред.

  1. Human PubMed Reference:. 
  2. Mouse PubMed Reference:. 
  3. (англ.). Архів оригіналу за 18 червня 2017. Процитовано 12 вересня 2017. 
  4. (англ.). Архів оригіналу за 23 липня 2017. Процитовано 12 вересня 2017. 

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Дата публікації:
ARFGEF2 angl ADP ribosylation factor guanine nucleotide exchange factor 2 bilok yakij koduyetsya odnojmennim genom roztashovanim u lyudej na korotkomu plechi 20 yi hromosomi 3 Dovzhina polipeptidnogo lancyuga bilka stanovit 1 785 aminokislot a molekulyarna masa 202 038 4 ARFGEF2Nayavni strukturiPDBPoshuk ortologiv PDBe RCSBSpisok kodiv PDB3L8N 3SWVIdentifikatoriSimvoliARFGEF2 BIG2 PVNH2 dJ1164I10 1 ADP ribosylation factor guanine nucleotide exchange factor 2Zovnishni ID OMIM 605371 MGI 2139354 HomoloGene 111880 GeneCards ARFGEF2Ontologiya genaMolekulyarna funkciya guanyl nucleotide exchange factor activity GABA receptor binding myosin binding GO 0001948 GO 0016582 protein binding protein kinase A regulatory subunit bindingKlitinna komponenta citoplazma recycling endosome gialoplazma endosoma kompleks Goldzhi cell projection membrana Golgi membrane dendritic spine sinaps Centr organizaciyi mikrotrubochok Mizhklitinni kontakti trans Golgi network Dendrit nejrobiologiya symmetric synapse asymmetric synapse perinuclear region of cytoplasm Citoskelet GO 0016023 cytoplasmic vesicle axonemal microtubuleBiologichnij proces endomembrane system organization GO 0007243 intracellular signal transduction regulation of ARF protein signal transduction endosome organization receptor recycling positive regulation of tumor necrosis factor production protein transport Golgi to plasma membrane transport ekzocitoz GO 0015915 transport regulation of molecular function vesicle mediated transportDzherela Amigo QuickGOShablon ekspresiyiBilshe danihOrtologiVidi Lyudina MishaEntrez10564 99371Ensembl ENSG00000124198 ENSMUSG00000074582UniProt Q9Y6D5 A2A5R2RefSeq mRNK NM 006420NM 001085495RefSeq bilok NP 006411NP 001078964Lokus UCSC Hr 20 48 92 49 04 MbHr 2 166 65 166 74 MbPubMed search 1 2 VikidaniDiv Red dlya lyudejDiv Red dlya mishej Poslidovnist aminokislot1020304050MQESQTKSMFVSRALEKILADKEVKRPQHSQLRRACQVALDEIKAEIEKQRLGTAAPPKANFIEADKYFLPFELACQSKSPRVVSTSLDCLQKLIAYGHITGNAPDSGAPGKRLIDRIVETICSCFQGPQTDEGVQLQIIKALLTAVTSPHIEIHEGTILQTVRTCYNIYLASKNLINQTTAKATLTQMLNVIFTRMENQVLQEARELEKPIQSKPQSPVIQAAAVSPKFVRLKHSQAQSKPTTPEKTDLTNGEHARSDSGKVSTENGDAPRERGSSLSGTDDGAQEVVKDILEDVVTSAIKEAAEKHGLTEPERVLGELECQECAIPPGVDENSQTNGIADDRQSLSSADNLESDAQGHQVAARFSHVLQKDAFLVFRSLCKLSMKPLGEGPPDPKSHELRSKVVSLQLLLSVLQNAGPVFRTHEMFINAIKQYLCVALSKNGVSSVPDVFELSLAIFLTLLSNFKMHLKMQIEVFFKEIFLNILETSTSSFEHRWMVIQTLTRICADAQCVVDIYVNYDCDLNAANIFERLVNDLSKIAQGRSGHELGMTPLQELSLRKKGLECLVSILKCMVEWSKDLYVNPNHQTSLGQERLTDQEIGDGKGLDMARRCSVTSMESTVSSGTQTTVQDDPEQFEVIKQQKEIIEHGIELFNKKPKRGIQFLQEQGMLGTSVEDIAQFLHQEERLDSTQVGDFLGDSARFNKEVMYAYVDQLDFCEKEFVSALRTFLEGFRLPGEAQKIDRLMEKFAARYIECNQGQTLFASADTAYVLAYSIIMLTTDLHSPQVKNKMTKEQYIKMNRGINDSKDLPEEYLSSIYEEIEGKKIAMKETKELTIATKSTKQNVASEKQRRLLYNLEMEQMAKTAKALMEAVSHAKAPFTSATHLDHVRPMFKLVWTPLLAAYSIGLQNCDDTEVASLCLEGIRCAIRIACIFGMQLERDAYVQALARFSLLTASSSITEMKQKNIDTIKTLITVAHTDGNYLGNSWHEILKCISQLELAQLIGTGVKTRYLSGSGREREGSLKGHTLAGEEFMGLGLGNLVSGGVDKRQMASFQESVGETSSQSVVVAVDRIFTGSTRLDGNAIVDFVRWLCAVSMDELASPHHPRMFSLQKIVEISYYNMNRIRLQWSRIWHVIGDHFNKVGCNPNEDVAIFAVDSLRQLSMKFLEKGELANFRFQKDFLRPFEHIMKKNRSPTIRDMAIRCIAQMVNSQAANIRSGWKNIFAVFHQAASDHDGNIVELAFQTTCHIVTTIFQHHFPAAIDSFQDAVKCLSEFACNAAFPDTSMEAIRLIRFCGKYVSERPRVLQEYTSDDMNVAPGDRVWVRGWFPILFELSCIINRCKLDVRTRGLTVMFEIMKSYGHTFEKHWWQDLFRIVFRIFDNMKLPEQLSEKSEWMTTTCNHALYAICDVFTQFYEALNEVLLSDVFAQLQWCVKQDNEQLARSGTNCLENLVISNGEKFSPEVWDETCNCMLDIFKTTIPHVLLTWRPVGMEEDSSEKHLDVDLDRQSLSSIDKNPSERGQSQLSNPTDDSWKGRPYANQKLFASLLIKCVVQLELIQTIDNIVFYPATSKKEDAEHMVAAQQDTLDADIHIETEDQGMYKYMSSQHLFKLLDCLQESHSFSKAFNSNYEQRTVLWRAGFKGKSKPNLLKQETSSLACCLRILFRMYVDENRRDSWEEIQQRLLTVCSEALAYFITVNSESHREAWTSLLLLLLTKTLKINDEKFKAHASMYYPYLCEIMQFDLIPELRAVLRKFFLRIGVVYKIWIPEEPSQVPAALSPVWA Alanin C Cisteyin D Asparaginova kislota E Glutaminova kislota F Fenilalanin G Glicin H Gistidin I Izolejcin K Lizin L Lejcin M Metionin N Asparagin P Prolin Q Glutamin R Arginin S Serin T Treonin V Valin W Triptofan Y Tirozin Kodovanij genom bilok za funkciyeyu nalezhit do fosfoproteyiniv Zadiyanij u takih biologichnih procesah yak transport transport bilkiv acetilyuvannya Lokalizovanij u citoplazmi citoskeleti membrani klitinnih kontaktah klitinnih vidrostkah citoplazmatichnih vezikulah aparati goldzhi sinapsah endosomah Literatura red Togawa A Morinaga N Ogasawara M Moss J Vaughan M 1999 Purification and cloning of a brefeldin A inhibited guanine nucleotide exchange protein for ADP ribosylation factors J Biol Chem 274 12308 12315 PubMed DOI 10 1074 jbc 274 18 12308 Shinotsuka C Waguri S Wakasugi M Uchiyama Y Nakayama K 2002 Dominant negative mutant of BIG2 an ARF guanine nucleotide exchange factor specifically affects membrane trafficking from the trans Golgi network through inhibiting membrane association of AP 1 and GGA coat proteins Biochem Biophys Res Commun 294 254 260 PubMed DOI 10 1016 S0006 291X 02 00456 4 Li H Adamik R Pacheco Rodriguez G Moss J Vaughan M 2003 Protein kinase A anchoring AKAP domains in brefeldin A inhibited guanine nucleotide exchange protein 2 BIG2 Proc Natl Acad Sci U S A 100 1627 1632 PubMed DOI 10 1073 pnas 0337678100 Shin H W Morinaga N Noda M Nakayama K 2004 BIG2 a guanine nucleotide exchange factor for ADP ribosylation factors its localization to recycling endosomes and implication in the endosome integrity Mol Biol Cell 15 5283 5294 PubMed DOI 10 1091 mbc E04 05 0388 Ishizaki R Shin H W Iguchi Ariga S M Ariga H Nakayama K 2006 AMY 1 associate of Myc 1 localization to the trans Golgi network through interacting with BIG2 a guanine nucleotide exchange factor for ADP ribosylation factors Genes Cells 11 949 959 PubMed DOI 10 1111 j 1365 2443 2006 00991 x Kuroda F Moss J Vaughan M 2007 Regulation of brefeldin A inhibited guanine nucleotide exchange protein 1 BIG1 and BIG2 activity via PKA and protein phosphatase 1gamma Proc Natl Acad Sci U S A 104 3201 3206 PubMed DOI 10 1073 pnas 0611696104Primitki red Human PubMed Reference Mouse PubMed Reference HUGO Gene Nomenclature Commitee HGNC 15853 angl Arhiv originalu za 18 chervnya 2017 Procitovano 12 veresnya 2017 UniProt Q9Y6D5 angl Arhiv originalu za 23 lipnya 2017 Procitovano 12 veresnya 2017 Div takozh red Hromosoma 20 nbsp Ce nezavershena stattya pro bilki Vi mozhete dopomogti proyektu vipravivshi abo dopisavshi yiyi Otrimano z https uk wikipedia org w index php title ARFGEF2 amp oldid 35337638