A1CF angl APOBEC1 complementation factor bilok yakij koduyetsya odnojmennim genom roztashovanim u lyudej na korotkomu plechi 10 yi hromosomi 3 Dovzhina polipeptidnogo lancyuga bilka stanovit 594 aminokislot a molekulyarna masa 65 202 4 A1CFNayavni strukturiPDBPoshuk ortologiv PDBe RCSBSpisok kodiv PDB2CPDIdentifikatoriSimvoliA1CF ACF ACF64 ACF65 APOBEC1CF ASP APOBEC1 complementation factorZovnishni ID OMIM 618199 MGI 1917115 HomoloGene 16363 GeneCards A1CFOntologiya genaMolekulyarna funkciya nucleic acid binding double stranded RNA binding GO 0001948 GO 0016582 protein binding single stranded RNA binding RNA binding mRNA bindingKlitinna komponenta citoplazma apolipoprotein B mRNA editing enzyme complex endoplazmatichnij retikulum klitinne yadro NukleoplazmaBiologichnij proces mRNA processing protein stabilization cytidine to uridine editing mRNA modification mRNA localization resulting in posttranscriptional regulation of gene expressionDzherela Amigo QuickGOShablon ekspresiyiBilshe danihOrtologiVidi Lyudina MishaEntrez29974 69865Ensembl ENSG00000148584 ENSMUSG00000052595UniProt Q9NQ94 Q5YD48RefSeq mRNK NM 001198818NM 001198819NM 001198820NM 014576NM 138932NM 138933NM 001370130NM 001370131NM 001081074NM 001365078RefSeq bilok NP 001185747NP 001185748NP 001185749NP 055391NP 620310NP 620311NP 001357059NP 001357060NP 001074543NP 001352007Lokus UCSC Hr 10 50 8 50 89 MbHr 19 31 85 31 93 MbPubMed search 1 2 VikidaniDiv Red dlya lyudejDiv Red dlya mishej Poslidovnist aminokislot1020304050MESNHKSGDGLSGTQKEAALRALVQRTGYSLVQENGQRKYGGPPPGWDAAPPERGCEIFIGKLPRDLFEDELIPLCEKIGKIYEMRMMMDFNGNNRGYAFVTFSNKVEAKNAIKQLNNYEIRNGRLLGVCASVDNCRLFVGGIPKTKKREEILSEMKKVTEGVVDVIVYPSAADKTKNRGFAFVEYESHRAAAMARRKLLPGRIQLWGHGIAVDWAEPEVEVDEDTMSSVKILYVRNLMLSTSEEMIEKEFNNIKPGAVERVKKIRDYAFVHFSNREDAVEAMKALNGKVLDGSPIEVTLAKPVDKDSYVRYTRGTGGRGTMLQGEYTYSLGQVYDPTTTYLGAPVFYAPQTYAAIPSLHFPATKGHLSNRAIIRAPSVREIYMNVPVGAAGVRGLGGRGYLAYTGLGRGYQVKGDKREDKLYDILPGMELTPMNPVTLKPQGIKLAPQILEEICQKNNWGQPVYQLHSAIGQDQRQLFLYKITIPALASQNPAIHPFTPPKLSAFVDEAKTYAAEYTLQTLGIPTDGGDGTMATAAAAATAFPGYAVPNATAPVSAAQLKQAVTLGQDLAAYTTYEVYPTFAVTARGDGYGTFA Alanin C Cisteyin D Asparaginova kislota E Glutaminova kislota F Fenilalanin G Glicin H Gistidin I Izolejcin K Lizin L Lejcin M Metionin N Asparagin P Prolin Q Glutamin R Arginin S Serin T Treonin V Valin W Triptofan Y Tirozin Kodovanij genom bilok za funkciyeyu nalezhit do fosfoproteyiniv Zadiyanij u takih biologichnih procesah yak procesing mRNK alternativnij splajsing Bilok maye sajt dlya zv yazuvannya z RNK Lokalizovanij u citoplazmi yadri endoplazmatichnomu retikulumi Cej bilok bere uchast u redaguvanni RNK shlyahom dezaminuvannya citidinu razom z bilkom APOBEC1 Kompleks redaguye vzhe zrili mRNK v yadri Vin rozpiznaye dilyanku RNK u 30 40 nukleotidiv yaka utvoryuye shpilku prichomu cilovij citozin mistitsya v golivci nesparenij dilyanci ciyeyi shpilki Bilok ACF vikonuye adaptornu funkciyu zabezpechuyuchi kontakt dezaminazi z RNK Kompleks rozpiznaye poslidovnist UUUN A U U yaka maye mistitisya dali za sajtom redaguvannya ta peretinayetsya z yakirnoyu poslidovnistyu do yakoyi priyednuyetsya molekula ACF Vid stupenya zbigu ciyeyi dilyanki riznih RNK z poslidovnistyu mRNK ApoB zalezhit efektivnist redaguvannya konkretnogo citidinu Literatura red Mehta A Kinter M T Sherman N E Driscoll D M 2000 Molecular cloning of APOBEC 1 complementation factor a novel RNA binding protein involved in the editing of apolipoprotein B mRNA Mol Cell Biol 20 1846 1854 PMID 10669759 DOI 10 1128 MCB 20 5 1846 1854 2000 The status quality and expansion of the NIH full length cDNA project the Mammalian Gene Collection MGC Genome Res 14 2121 2127 2004 PMID 15489334 DOI 10 1101 gr 2596504 Henderson J O Blanc V Davidson N O 2001 Isolation characterization and developmental regulation of the human apobec 1 complementation factor ACF gene Biochim Biophys Acta 1522 22 30 PMID 11718896 DOI 10 1016 S0167 4781 01 00295 0 Mehta A Driscoll D M 2002 Identification of domains in apobec 1 complementation factor required for RNA binding and apolipoprotein B mRNA editing RNA 8 69 82 PMID 11871661 DOI 10 1017 S1355838202015649 Blanc V Kennedy S Davidson N O 2003 A novel nuclear localization signal in the auxiliary domain of apobec 1 complementation factor regulates nucleocytoplasmic import and shuttling J Biol Chem 278 41198 41204 PMID 12896982 DOI 10 1074 jbc M302951200Primitki red Human PubMed Reference Mouse PubMed Reference HUGO Gene Nomenclature Commitee HGNC 24086 angl Arhiv originalu za 15 veresnya 2017 Procitovano 8 veresnya 2017 UniProt Q9NQ94 angl Arhiv originalu za 20 serpnya 2017 Procitovano 8 veresnya 2017 Div takozh red Hromosoma 10 nbsp Ce nezavershena stattya pro bilki Vi mozhete dopomogti proyektu vipravivshi abo dopisavshi yiyi Otrimano z https uk wikipedia org w index php title A1CF amp oldid 38133044
