GATM angl Glycine amidinotransferase bilok yakij koduyetsya odnojmennim genom roztashovanim u lyudej na korotkomu plechi 15 yi hromosomi 4 Dovzhina polipeptidnogo lancyuga bilka stanovit 423 aminokislot a molekulyarna masa 48 455 5 GATMNayavni strukturiPDBPoshuk ortologiv PDBe RCSBSpisok kodiv PDB1JDW 1JDX 2JDW 2JDX 3JDW 4JDW 5JDW 6JDW 7JDW 8JDW 9JDWIdentifikatoriSimvoliGATM AGAT AT CCDS3 glycine amidinotransferase FRTS1Zovnishni ID OMIM 602360 MGI 1914342 HomoloGene 1136 GeneCards GATMPov yazani genetichni zahvoryuvannyaAGAT deficiency 1 Ontologiya genaMolekulyarna funkciya transferase activity glycine amidinotransferase activity amidinotransferase activityKlitinna komponenta membrana citoplazma mitohondrialna vnutrishnya membrana ekzosoma mitohondrialnij mizhmembrannij prostir mitohondriyaBiologichnij proces creatine biosynthetic process creatine metabolic process multicellular organism development learning or memory m yazova atrofiya positive regulation of cold induced thermogenesisDzherela Amigo QuickGOShablon ekspresiyiBilshe danihOrtologiVidi Lyudina MishaEntrez2628 67092Ensembl ENSG00000171766 ENSMUSG00000027199UniProt P50440 Q9D964RefSeq mRNK NM 001482NM 001321015NM 025961RefSeq bilok NP 001307944NP 001473NP 080237Lokus UCSC Hr 15 45 36 45 4 MbHr 2 122 42 122 44 MbPubMed search 2 3 VikidaniDiv Red dlya lyudejDiv Red dlya mishej Poslidovnist aminokislot1020304050MLRVRCLRGGSRGAEAVHYIGSRLGRTLTGWVQRTFQSTQAATASSRNSCAADDKATEPLPKDCPVSSYNEWDPLEEVIVGRAENACVPPFTIEVKANTYEKYWPFYQKQGGHYFPKDHLKKAVAEIEEMCNILKTEGVTVRRPDPIDWSLKYKTPDFESTGLYSAMPRDILIVVGNEIIEAPMAWRSRFFEYRAYRSIIKDYFHRGAKWTTAPKPTMADELYNQDYPIHSVEDRHKLAAQGKFVTTEFEPCFDAADFIRAGRDIFAQRSQVTNYLGIEWMRRHLAPDYRVHIISFKDPNPMHIDATFNIIGPGIVLSNPDRPCHQIDLFKKAGWTIITPPTPIIPDDHPLWMSSKWLSMNVLMLDEKRVMVDANEVPIQKMFEKLGITTIKVNIRNANSLGGGFHCWTCDVRRRGTLQSYLDA Alanin C Cisteyin D Asparaginova kislota E Glutaminova kislota F Fenilalanin G Glicin H Gistidin I Izolejcin K Lizin L Lejcin M Metionin N Asparagin P Prolin Q Glutamin R Arginin S Serin T Treonin V Valin W Triptofan Y Tirozin Kodovanij genom bilok za funkciyami nalezhit do transferaz fosfoproteyiniv Zadiyanij u takih biologichnih procesah yak acetilyuvannya alternativnij splajsing Lokalizovanij u citoplazmi membrani mitohondriyi vnutrishnij membrani mitohondriyi Literatura red Humm A Huber R Mann K 1994 The amino acid sequences of human and pig L arginine glycine amidinotransferase FEBS Lett 339 101 107 PubMed DOI 10 1016 0014 5793 94 80394 3 The status quality and expansion of the NIH full length cDNA project the Mammalian Gene Collection MGC Genome Res 14 2121 2127 2004 PubMed DOI 10 1101 gr 2596504 Gross M D Eggen M A Simon A M Van Pilsum J F 1986 The purification and characterization of human kidney L arginine glycine amidinotransferase Arch Biochem Biophys 251 747 755 PubMed DOI 10 1016 0003 9861 86 90385 1 Humm A Fritsche E Mann K Goehl U Huber R 1997 Recombinant expression and isolation of human L arginine glycine amidinotransferase and identification of its active site cysteine residue Biochem J 322 771 776 PubMed DOI 10 1042 bj3220771 Humm A Fritsche E Steinbacher S Huber R 1997 Crystal structure and mechanism of human L arginine glycine amidinotransferase a mitochondrial enzyme involved in creatine biosynthesis EMBO J 16 3373 3385 PubMed DOI 10 1093 emboj 16 12 3373 Fritsche E Humm A Huber R 1997 Substrate binding and catalysis by L arginine glycine amidinotransferase a mutagenesis and crystallographic study Eur J Biochem 247 483 490 PubMed DOI 10 1111 j 1432 1033 1997 00483 xPrimitki red Zahvoryuvannya genetichno pov yazani z GATM pereglyanuti redaguvati posilannya na VikiDanih Human PubMed Reference Mouse PubMed Reference HUGO Gene Nomenclature Commitee HGNC 4175 angl Procitovano 11 veresnya 2017 UniProt P50440 angl Arhiv originalu za 25 serpnya 2017 Procitovano 11 veresnya 2017 Div takozh red Hromosoma 15 nbsp Ce nezavershena stattya pro bilki Vi mozhete dopomogti proyektu vipravivshi abo dopisavshi yiyi Otrimano z https uk wikipedia org w index php title GATM amp oldid 38242211
