UBE3A angl Ubiquitin protein ligase E3A bilok yakij koduyetsya odnojmennim genom roztashovanim u lyudej na korotkomu plechi 15 yi hromosomi 4 Dovzhina polipeptidnogo lancyuga bilka stanovit 875 aminokislot a molekulyarna masa 100 688 5 UBE3ANayavni strukturiPDBPoshuk ortologiv PDBe RCSBSpisok kodiv PDB4GIZ 1C4Z 1D5F 1EQX 2KR1IdentifikatoriSimvoliUBE3A ANCR AS E6 AP EPVE6AP HPVE6A ubiquitin protein ligase E3A PIX1Zovnishni ID OMIM 601623 MGI 105098 HomoloGene 7988 GeneCards UBE3APov yazani genetichni zahvoryuvannyaozhirinnya sindrom Angelmana 1 Ontologiya genaMolekulyarna funkciya zv yazuvannya z ionom metalu GO 0001105 transcription coactivator activity GO 0050372 ubiquitin protein transferase activity GO 0001948 GO 0016582 protein binding GO 1904264 GO 1904822 GO 0090622 GO 0090302 ubiquitin protein ligase activity transferase activityKlitinna komponenta gialoplazma Proteasoma klitinne yadro citoplazmaBiologichnij proces ubiquitin dependent protein catabolic process prostate gland growth ritmichnij proces proteoliz positive regulation of phosphatidylinositol 3 kinase signaling protein K48 linked ubiquitination GO 0022415 viral process brain development regulation of ubiquitin dependent protein catabolic process ovarian follicle development sperm entry Ubikvitin zalezhnij proteoliz positive regulation of protein ubiquitination GO 0003257 GO 0010735 GO 1901228 GO 1900622 GO 1904488 positive regulation of transcription by RNA polymerase II protein autoubiquitination regulation of circadian rhythm androgen receptor signaling pathway response to progesterone progesterone receptor signaling pathway protein polyubiquitination proteasome mediated ubiquitin dependent protein catabolic process response to cocaine response to hydrogen peroxide negative regulation of dendritic spine morphogenesis cellular response to brain derived neurotrophic factor stimulusDzherela Amigo QuickGOShablon ekspresiyiBilshe danihOrtologiVidi Lyudina MishaEntrez7337 22215Ensembl ENSG00000114062 ENSMUSG00000025326UniProt Q05086 O08759RefSeq mRNK NM 000462NM 130838NM 130839NM 001354505NM 001354506NM 001354509NM 001354512NM 001354523NM 001354526NM 001354540NM 001354541NM 001354543NM 001354545NM 001354547NM 001354549NM 001354550NM 001354507NM 001354508NM 001354511NM 001354513NM 001354538NM 001354539NM 001354542NM 001354544NM 001354546NM 001354548NM 001354551NM 001374461NM 001033962NM 011668NM 173010RefSeq bilok NP 000453NP 570853NP 570854NP 001341434NP 001341435NP 001341438NP 001341441NP 001341452NP 001341455NP 001341469NP 001341470NP 001341472NP 001341474NP 001341476NP 001341478NP 001341479NP 001341436NP 001341437NP 001341440NP 001341442NP 001341467NP 001341468NP 001341471NP 001341473NP 001341475NP 001341477NP 001341480NP 001361390NP 001029134NP 035798NP 001380595NP 001380597NP 001380598NP 001380599NP 001380600NP 001380601NP 766598NP 001380902Lokus UCSC Hr 15 25 33 25 44 MbHr 7 59 23 59 31 MbPubMed search 2 3 VikidaniDiv Red dlya lyudejDiv Red dlya mishej Poslidovnist aminokislot1020304050MEKLHQCYWKSGEPQSDDIEASRMKRAAAKHLIERYYHQLTEGCGNEACTNEFCASCPTFLRMDNNAAAIKALELYKINAKLCDPHPSKKGASSAYLENSKGAPNNSCSEIKMNKKGARIDFKDVTYLTEEKVYEILELCREREDYSPLIRVIGRVFSSAEALVQSFRKVKQHTKEELKSLQAKDEDKDEDEKEKAACSAAAMEEDSEASSSRIGDSSQGDNNLQKLGPDDVSVDIDAIRRVYTRLLSNEKIETAFLNALVYLSPNVECDLTYHNVYSRDPNYLNLFIIVMENRNLHSPEYLEMALPLFCKAMSKLPLAAQGKLIRLWSKYNADQIRRMMETFQQLITYKVISNEFNSRNLVNDDDAIVAASKCLKMVYYANVVGGEVDTNHNEEDDEEPIPESSELTLQELLGEERRNKKGPRVDPLETELGVKTLDCRKPLIPFEEFINEPLNEVLEMDKDYTFFKVETENKFSFMTCPFILNAVTKNLGLYYDNRIRMYSERRITVLYSLVQGQQLNPYLRLKVRRDHIIDDALVRLEMIAMENPADLKKQLYVEFEGEQGVDEGGVSKEFFQLVVEEIFNPDIGMFTYDESTKLFWFNPSSFETEGQFTLIGIVLGLAIYNNCILDVHFPMVVYRKLMGKKGTFRDLGDSHPVLYQSLKDLLEYEGNVEDDMMITFQISQTDLFGNPMMYDLKENGDKIPITNENRKEFVNLYSDYILNKSVEKQFKAFRRGFHMVTNESPLKYLFRPEEIELLICGSRNLDFQALEETTEYDGGYTRDSVLIREFWEIVHSFTDEQKRLFLQFTTGTDRAPVGGLGKLKMIIAKNGPDTERLPTSHTCFNVLLLPEYSSKEKLKERLLKAITYAKGFGMLA Alanin C Cisteyin D Asparaginova kislota E Glutaminova kislota F Fenilalanin G Glicin H Gistidin I Izolejcin K Lizin L Lejcin M Metionin N Asparagin P Prolin Q Glutamin R Arginin S Serin T Treonin V Valin W Triptofan Y Tirozin Kodovanij genom bilok za funkciyami nalezhit do transferaz fosfoproteyiniv Zadiyanij u takih biologichnih procesah yak vzayemodiya hazyayin virus biologichni ritmi ubikvitinuvannya bilkiv alternativnij splajsing Bilok maye sajt dlya zv yazuvannya z ionami metaliv ionom cinku Lokalizovanij u citoplazmi yadri Literatura red Yamamoto Y Huibregtse J M Howley P M 1997 The human E6 AP gene UBE3A encodes three potential protein isoforms generated by differential splicing Genomics 41 263 266 PubMed DOI 10 1006 geno 1997 4617 Kishino T Lalande M Wagstaff J 1997 UBE3A E6 AP mutations cause Angelman syndrome Nat Genet 15 70 73 PubMed DOI 10 1038 ng0197 70 Huibregtse J M Scheffner M Howley P M 1993 Cloning and expression of the cDNA for E6 AP a protein that mediates the interaction of the human papillomavirus E6 oncoprotein with p53 Mol Cell Biol 13 775 784 PubMed DOI 10 1128 MCB 13 2 775 Nuber U Schwarz S E Scheffner M 1998 The ubiquitin protein ligase E6 associated protein E6 AP serves as its own substrate Eur J Biochem 254 643 649 PubMed DOI 10 1046 j 1432 1327 1998 2540643 x Kumar S Talis A L Howley P M 1999 Identification of HHR23A as a substrate for E6 associated protein mediated ubiquitination J Biol Chem 274 18785 18792 PubMed DOI 10 1074 jbc 274 26 18785 Wong E Y Tse J Y Yao K M Tam P C Yeung W S 2002 VCY2 protein interacts with the HECT domain of ubiquitin protein ligase E3A Biochem Biophys Res Commun 296 1104 1111 PubMed DOI 10 1016 S0006 291X 02 02040 5Primitki red Zahvoryuvannya genetichno pov yazani z UBE3A pereglyanuti redaguvati posilannya na VikiDanih Human PubMed Reference Mouse PubMed Reference HUGO Gene Nomenclature Commitee HGNC 12496 angl Arhiv originalu za 23 veresnya 2017 Procitovano 11 veresnya 2017 UniProt Q05086 angl Arhiv originalu za 21 veresnya 2017 Procitovano 11 veresnya 2017 Div takozh red Hromosoma 15 nbsp Ce nezavershena stattya pro bilki Vi mozhete dopomogti proyektu vipravivshi abo dopisavshi yiyi Otrimano z https uk wikipedia org w index php title UBE3A amp oldid 35756815
