TLR2 angl Toll like receptor 2 bilok yakij koduyetsya odnojmennim genom roztashovanim u lyudej na korotkomu plechi 4 yi hromosomi 3 Dovzhina polipeptidnogo lancyuga bilka stanovit 784 aminokislot a molekulyarna masa 89 838 4 TLR2Nayavni strukturiPDBPoshuk ortologiv PDBe RCSBSpisok kodiv PDB1FYW 1FYX 1O77 2Z7X 2Z80IdentifikatoriSimvoliTLR2 CD282 TIL4 toll like receptor 2Zovnishni ID OMIM 603028 MGI 1346060 HomoloGene 20695 GeneCards TLR2Ontologiya genaMolekulyarna funkciya GO 0008329 pattern recognition receptor activity lipopolysaccharide binding Toll like receptor binding triacyl lipopeptide binding GO 0001948 GO 0016582 protein binding peptidoglycan binding protein heterodimerization activity lipopolysaccharide immune receptor activity transmembrane signaling receptor activity lipopeptidnij zv yazokKlitinna komponenta citoplazma integral component of membrane phagocytic vesicle membrane kompleks Goldzhi membrana intrinsic component of plasma membrane klitinna membrana Toll like receptor 1 Toll like receptor 2 protein complex integral component of plasma membrane membrane raft GO 0016023 cytoplasmic vesicle cell projection cell surface cell bodyBiologichnij proces interleukin 10 production positive regulation of interferon beta production GO 0051637 defense response to Gram positive bacterium positive regulation of interleukin 18 production positive regulation of toll like receptor signaling pathway toll like receptor TLR1 TLR2 signaling pathway positive regulation of inflammatory response cellular response to bacterial lipopeptide positive regulation of interleukin 12 production immune system process detection of diacyl bacterial lipopeptide cellular response to diacyl bacterial lipopeptide I kappaB phosphorylation positive regulation of nitric oxide synthase biosynthetic process MyD88 dependent toll like receptor signaling pathway cellular response to triacyl bacterial lipopeptide detection of triacyl bacterial lipopeptide positive regulation of Wnt signaling pathway GO 1901313 positive regulation of gene expression cellular response to lipoteichoic acid positive regulation of NF kappaB transcription factor activity GO 0046730 GO 0046737 GO 0046738 GO 0046736 Imunna vidpovid positive regulation of interleukin 8 production positive regulation of interleukin 6 production positive regulation of tumor necrosis factor production positive regulation of chemokine production Vrodzhenij imunitet inflammatory response toll like receptor TLR6 TLR2 signaling pathway response to molecule of bacterial origin GO 0072468 Signalna transdukciya GO 0003257 GO 0010735 GO 1901228 GO 1900622 GO 1904488 positive regulation of transcription by RNA polymerase II GO 0097285 Apoptoz response to lipopolysaccharide response to progesterone toll like receptor signaling pathway response to insulin central nervous system myelin formation nitric oxide metabolic process response to fatty acid leukotriene metabolic process toll like receptor 2 signaling pathway positive regulation of oligodendrocyte differentiation response to bacterial lipoprotein negative regulation of cell population proliferation response to toxic substance response to hypoxia positive regulation of interleukin 10 production lipopolysaccharide mediated signaling pathway microglial cell activationDzherela Amigo QuickGOShablon ekspresiyiBilshe danihOrtologiVidi Lyudina MishaEntrez7097 24088Ensembl ENSG00000137462 ENSMUSG00000027995UniProt O60603 Q9QUN7RefSeq mRNK NM 003264NM 001318787NM 001318789NM 001318790NM 001318791NM 001318793NM 001318795NM 001318796NM 011905RefSeq bilok NP 001305716NP 001305718NP 001305719NP 001305720NP 001305722NP 001305724NP 001305725NP 003255NP 036035Lokus UCSC Hr 4 153 68 153 71 MbHr 3 83 74 83 75 MbPubMed search 1 2 VikidaniDiv Red dlya lyudejDiv Red dlya mishej Poslidovnist aminokislot1020304050MPHTLWMVWVLGVIISLSKEESSNQASLSCDRNGICKGSSGSLNSIPSGLTEAVKSLDLSNNRITYISNSDLQRCVNLQALVLTSNGINTIEEDSFSSLGSLEHLDLSYNYLSNLSSSWFKPLSSLTFLNLLGNPYKTLGETSLFSHLTKLQILRVGNMDTFTKIQRKDFAGLTFLEELEIDASDLQSYEPKSLKSIQNVSHLILHMKQHILLLEIFVDVTSSVECLELRDTDLDTFHFSELSTGETNSLIKKFTFRNVKITDESLFQVMKLLNQISGLLELEFDDCTLNGVGNFRASDNDRVIDPGKVETLTIRRLHIPRFYLFYDLSTLYSLTERVKRITVENSKVFLVPCLLSQHLKSLEYLDLSENLMVEEYLKNSACEDAWPSLQTLILRQNHLASLEKTGETLLTLKNLTNIDISKNSFHSMPETCQWPEKMKYLNLSSTRIHSVTGCIPKTLEILDVSNNNLNLFSLNLPQLKELYISRNKLMTLPDASLLPMLLVLKISRNAITTFSKEQLDSFHTLKTLEAGGNNFICSCEFLSFTQEQQALAKVLIDWPANYLCDSPSHVRGQQVQDVRLSVSECHRTALVSGMCCALFLLILLTGVLCHRFHGLWYMKMMWAWLQAKRKPRKAPSRNICYDAFVSYSERDAYWVENLMVQELENFNPPFKLCLHKRDFIPGKWIIDNIIDSIEKSHKTVFVLSENFVKSEWCKYELDFSHFRLFDENNDAAILILLEPIEKKAIPQRFCKLRKIMNTKTYLEWPMDEAQREGFWVNLRAAIKSA Alanin C Cisteyin D Asparaginova kislota E Glutaminova kislota F Fenilalanin G Glicin H Gistidin I Izolejcin K Lizin L Lejcin M Metionin N Asparagin P Prolin Q Glutamin R Arginin S Serin T Treonin V Valin W Triptofan Y Tirozin Kodovanij genom bilok za funkciyeyu nalezhit do receptoriv Zadiyanij u takih biologichnih procesah yak imunitet vrodzhenij imunitet zapalna vidpovid polimorfizm Lokalizovanij u membrani citoplazmatichnih vezikulah Literatura red Rock F L Hardiman G Timans J C Kastelein R A Bazan J F 1998 A family of human receptors structurally related to Drosophila Toll Proc Natl Acad Sci U S A 95 588 593 PubMed DOI 10 1073 pnas 95 2 588 Georgel P Macquin C Bahram S 2009 The heterogeneous allelic repertoire of human Toll Like receptor TLR genes PLoS ONE 4 E7803 E7803 PubMed DOI 10 1371 journal pone 0007803 The status quality and expansion of the NIH full length cDNA project the Mammalian Gene Collection MGC Genome Res 14 2121 2127 2004 PubMed DOI 10 1101 gr 2596504 Bulut Y Faure E Thomas L Equils O Arditi M 2001 Cooperation of Toll like receptor 2 and 6 for cellular activation by soluble tuberculosis factor and Borrelia burgdorferi outer surface protein A lipoprotein role of Toll interacting protein and IL 1 receptor signaling molecules in Toll like receptor 2 signaling J Immunol 167 987 994 PubMed DOI 10 4049 jimmunol 167 2 987 Weber A N Morse M A Gay N J 2004 Four N linked glycosylation sites in human toll like receptor 2 cooperate to direct efficient biosynthesis and secretion J Biol Chem 279 34589 34594 PubMed DOI 10 1074 jbc M403830200 Kang T J Chae G T 2001 Detection of Toll like receptor 2 TLR2 mutation in the lepromatous leprosy patients FEMS Immunol Med Microbiol 31 53 58 PubMed DOI 10 1111 j 1574 695X 2001 tb01586 xPrimitki red Human PubMed Reference Mouse PubMed Reference HUGO Gene Nomenclature Commitee HGNC 11848 angl Arhiv originalu za 1 zhovtnya 2016 Procitovano 30 serpnya 2017 UniProt O60603 angl Arhiv originalu za 29 serpnya 2017 Procitovano 30 serpnya 2017 Div takozh red Hromosoma 4 nbsp Ce nezavershena stattya pro bilki Vi mozhete dopomogti proyektu vipravivshi abo dopisavshi yiyi Otrimano z https uk wikipedia org w index php title TLR2 amp oldid 35742391
