TGM2 angl Transglutaminase 2 bilok yakij koduyetsya odnojmennim genom roztashovanim u lyudej na korotkomu plechi 20 yi hromosomi 3 Dovzhina polipeptidnogo lancyuga bilka stanovit 687 aminokislot a molekulyarna masa 77 329 4 TGM2Nayavni strukturiPDBPoshuk ortologiv PDBe RCSBSpisok kodiv PDB4PYG 1KV3 2Q3Z 3LY6 3S3J 3S3P 3S3SIdentifikatoriSimvoliTGM2 G ALPHA h GNAH HEL S 45 TG2 TGC TG C transglutaminase 2 G h hTG2 tTGZovnishni ID OMIM 190196 MGI 98731 HomoloGene 3391 GeneCards TGM2Ontologiya genaMolekulyarna funkciya transferase activity acyltransferase activity protein glutamine gamma glutamyltransferase activity GO 0001948 GO 0016582 protein binding zv yazuvannya z ionom metalu GTP binding protein domain specific bindingKlitinna komponenta citoplazma intrinsic component of plasma membrane gialoplazma ekzosoma focal adhesion mitohondriya endoplazmatichnij retikulum klitinna membrana GO 0005578 Pozaklitinna matricya collagen containing extracellular matrixBiologichnij proces apoptotic cell clearance phospholipase C activating G protein coupled receptor signaling pathway salivary gland cavitation negative regulation of endoplasmic reticulum calcium ion concentration positive regulation of mitochondrial calcium ion concentration GO 0051357 GO 0051358 GO 0051359 peptide cross linking positive regulation of cell adhesion branching involved in salivary gland morphogenesis positive regulation of inflammatory response positive regulation of I kappaB kinase NF kappaB signaling positive regulation of cytosolic calcium ion concentration involved in phospholipase C activating G protein coupled signaling pathway isopeptide cross linking via N6 L isoglutamyl L lysine positive regulation of apoptotic process protein homooligomerization positive regulation of smooth muscle cell proliferation blood vessel remodelingDzherela Amigo QuickGOShablon ekspresiyiBilshe danihOrtologiVidi Lyudina MishaEntrez7052 21817Ensembl ENSG00000198959 ENSMUSG00000037820UniProt P21980 P21981RefSeq mRNK NM 004613NM 198951NM 001323316NM 001323317NM 001323318NM 009373RefSeq bilok NP 001310245NP 001310246NP 001310247NP 004604NP 945189NP 033399Lokus UCSC Hr 20 38 13 38 17 MbHr 2 157 96 157 99 MbPubMed search 1 2 VikidaniDiv Red dlya lyudejDiv Red dlya mishej Poslidovnist aminokislot1020304050MAEELVLERCDLELETNGRDHHTADLCREKLVVRRGQPFWLTLHFEGRNYEASVDSLTFSVVTGPAPSQEAGTKARFPLRDAVEEGDWTATVVDQQDCTLSLQLTTPANAPIGLYRLSLEASTGYQGSSFVLGHFILLFNAWCPADAVYLDSEEERQEYVLTQQGFIYQGSAKFIKNIPWNFGQFEDGILDICLILLDVNPKFLKNAGRDCSRRSSPVYVGRVVSGMVNCNDDQGVLLGRWDNNYGDGVSPMSWIGSVDILRRWKNHGCQRVKYGQCWVFAAVACTVLRCLGIPTRVVTNYNSAHDQNSNLLIEYFRNEFGEIQGDKSEMIWNFHCWVESWMTRPDLQPGYEGWQALDPTPQEKSEGTYCCGPVPVRAIKEGDLSTKYDAPFVFAEVNADVVDWIQQDDGSVHKSINRSLIVGLKISTKSVGRDEREDITHTYKYPEGSSEEREAFTRANHLNKLAEKEETGMAMRIRVGQSMNMGSDFDVFAHITNNTAEEYVCRLLLCARTVSYNGILGPECGTKYLLNLNLEPFSEKSVPLCILYEKYRDCLTESNLIKVRALLVEPVINSYLLAERDLYLENPEIKIRILGEPKQKRKLVAEVSLQNPLPVALEGCTFTVEGAGLTEEQKTVEIPDPVEAGEEVKVRMDLLPLHMGLHKLVVNFESDKLKAVKGFRNVIIGPAA Alanin C Cisteyin D Asparaginova kislota E Glutaminova kislota F Fenilalanin G Glicin H Gistidin I Izolejcin K Lizin L Lejcin M Metionin N Asparagin P Prolin Q Glutamin R Arginin S Serin T Treonin V Valin W Triptofan Y Tirozin Kodovanij genom bilok za funkciyami nalezhit do transferaz aciltransferaz fosfoproteyiniv Zadiyanij u takih biologichnih procesah yak acetilyuvannya alternativnij splajsing Bilok maye sajt dlya zv yazuvannya z ionami metaliv ionom kalciyu Literatura red Fraij B M Gonzales R A 1996 A third human tissue transglutaminase homologue as a result of alternative gene transcripts Biochim Biophys Acta 1306 63 74 PMID 8611626 DOI 10 1016 0167 4781 95 00219 7 The status quality and expansion of the NIH full length cDNA project the Mammalian Gene Collection MGC Genome Res 14 2121 2127 2004 PMID 15489334 DOI 10 1101 gr 2596504 Pinkas D M Strop P Brunger A T Khosla C 2007 Transglutaminase 2 undergoes a large conformational change upon activation PLoS Biol 5 E327 E327 PMID 18092889 DOI 10 1371 journal pbio 0050327 Fraij B M Birckbichler P J Patterson M K Jr Lee K N Gonzales R A 1992 A retinoic acid inducible mRNA from human erythroleukemia cells encodes a novel tissue transglutaminase homologue J Biol Chem 267 22616 22623 PMID 1358880Primitki red Human PubMed Reference Mouse PubMed Reference HUGO Gene Nomenclature Commitee HGNC 11778 angl Arhiv originalu za 15 listopada 2015 Procitovano 12 veresnya 2017 UniProt P21980 angl Arhiv originalu za 25 veresnya 2017 Procitovano 12 veresnya 2017 Div takozh red Hromosoma 20 nbsp Ce nezavershena stattya pro bilki Vi mozhete dopomogti proyektu vipravivshi abo dopisavshi yiyi Otrimano z https uk wikipedia org w index php title TGM2 amp oldid 38132892
