PDGFRA angl Platelet derived growth factor receptor alpha bilok yakij koduyetsya odnojmennim genom roztashovanim u lyudej na korotkomu plechi 4 yi hromosomi 5 Dovzhina polipeptidnogo lancyuga bilka stanovit 1 089 aminokislot a molekulyarna masa 122 670 6 PDGFRANayavni strukturiPDBPoshuk ortologiv PDBe RCSBSpisok kodiv PDB1GQ5IdentifikatoriSimvoliPDGFRA CD140A PDGFR 2 PDGFR2 RHEGAS9 platelet derived growth factor receptor alphaZovnishni ID OMIM 173490 MGI 97530 HomoloGene 31361 GeneCards PDGFRAPov yazani genetichni zahvoryuvannyaAstigmatizm gastrointestinal stromal tumor 1 Reaguye na spolukucediranib crenolanib Masitinib Nintedanib 2 Ontologiya genaMolekulyarna funkciya vascular endothelial growth factor activated receptor activity transferase activity protein kinase activity nucleotide binding protein homodimerization activity vascular endothelial growth factor binding platelet derived growth factor receptor binding kinase activity GO 0001948 GO 0016582 protein binding transmembrane receptor protein tyrosine kinase activity platelet derived growth factor alpha receptor activity protein tyrosine kinase activity ATP binding phosphatidylinositol 4 5 bisphosphate 3 kinase activity GO 0032403 protein containing complex binding platelet derived growth factor bindingKlitinna komponenta integral component of membrane membrana intrinsic component of plasma membrane integral component of plasma membrane klitinna membrana Mizhklitinni kontakti klitinne yadro citoplazma Mikrovorsinki external side of plasma membrane cell surface kompleks Goldzhi Vijka GO 0009327 protein containing complex cell projection receptor complexBiologichnij proces embryonic skeletal system morphogenesis regulation of actin cytoskeleton reorganization regulation of chemotaxis fosforilyuvannya positive regulation of phospholipase C activity transmembrane receptor protein tyrosine kinase signaling pathway positive regulation of cell migration positive regulation of fibroblast proliferation positive regulation of cytosolic calcium ion concentration cell activation MAPK cascade positive regulation of phosphatidylinositol 3 kinase activity GO 0072353 cellular response to reactive oxygen species positive regulation of DNA replication negative regulation of platelet activation protein phosphorylation hemotaksis multicellular organism development positive regulation of cell population proliferation positive regulation of cell proliferation by VEGF activated platelet derived growth factor receptor signaling pathway positive regulation of ERK1 and ERK2 cascade positive regulation of phosphatidylinositol 3 kinase signaling platelet derived growth factor receptor signaling pathway GO 0022415 viral process platelet aggregation regulation of mesenchymal stem cell differentiation phosphatidylinositol phosphate biosynthetic process negative regulation of platelet derived growth factor receptor beta signaling pathway luteinization in utero embryonic development hematopoietic progenitor cell differentiation estrogen metabolic process female gonad development anatomical structure morphogenesis animal organ morphogenesis cell migration peptidyl tyrosine phosphorylation signal transduction involved in regulation of gene expression extracellular matrix organization lung development adrenal gland development male genitalia development Leydig cell differentiation platelet derived growth factor receptor alpha signaling pathway Zagoyennya ran odontogenesis of dentin containing tooth protein autophosphorylation embryonic digestive tract morphogenesis embryonic cranial skeleton morphogenesis skeletal system morphogenesis cardiac myofibril assembly roof of mouth development face morphogenesis cell chemotaxis retina vasculature development in camera type eye cellular response to amino acid stimulus metanephric glomerular capillary formation phosphatidylinositol mediated signaling positive regulation of protein kinase B signaling positive regulation of MAPK cascadeDzherela Amigo QuickGOShablon ekspresiyiBilshe danihOrtologiVidi Lyudina MishaEntrez5156 18595Ensembl ENSG00000134853 ENSMUSG00000029231UniProt P16234 P26618RefSeq mRNK NM 006206NM 001347827NM 001347828NM 001347829NM 001347830NM 001083316NM 011058NM 001347718NM 001347719RefSeq bilok NP 001334756NP 001334757NP 001334758NP 001334759NP 006197NP 001076785NP 001334647NP 001334648NP 035188Lokus UCSC Hr 4 54 23 54 3 MbHr 5 75 31 75 36 MbPubMed search 3 4 VikidaniDiv Red dlya lyudejDiv Red dlya mishej Poslidovnist aminokislot1020304050MGTSHPAFLVLGCLLTGLSLILCQLSLPSILPNENEKVVQLNSSFSLRCFGESEVSWQYPMSEEESSDVEIRNEENNSGLFVTVLEVSSASAAHTGLYTCYYNHTQTEENELEGRHIYIYVPDPDVAFVPLGMTDYLVIVEDDDSAIIPCRTTDPETPVTLHNSEGVVPASYDSRQGFNGTFTVGPYICEATVKGKKFQTIPFNVYALKATSELDLEMEALKTVYKSGETIVVTCAVFNNEVVDLQWTYPGEVKGKGITMLEEIKVPSIKLVYTLTVPEATVKDSGDYECAARQATREVKEMKKVTISVHEKGFIEIKPTFSQLEAVNLHEVKHFVVEVRAYPPPRISWLKNNLTLIENLTEITTDVEKIQEIRYRSKLKLIRAKEEDSGHYTIVAQNEDAVKSYTFELLTQVPSSILDLVDDHHGSTGGQTVRCTAEGTPLPDIEWMICKDIKKCNNETSWTILANNVSNIITEIHSRDRSTVEGRVTFAKVEETIAVRCLAKNLLGAENRELKLVAPTLRSELTVAAAVLVLLVIVIISLIVLVVIWKQKPRYEIRWRVIESISPDGHEYIYVDPMQLPYDSRWEFPRDGLVLGRVLGSGAFGKVVEGTAYGLSRSQPVMKVAVKMLKPTARSSEKQALMSELKIMTHLGPHLNIVNLLGACTKSGPIYIITEYCFYGDLVNYLHKNRDSFLSHHPEKPKKELDIFGLNPADESTRSYVILSFENNGDYMDMKQADTTQYVPMLERKEVSKYSDIQRSLYDRPASYKKKSMLDSEVKNLLSDDNSEGLTLLDLLSFTYQVARGMEFLASKNCVHRDLAARNVLLAQGKIVKICDFGLARDIMHDSNYVSKGSTFLPVKWMAPESIFDNLYTTLSDVWSYGILLWEIFSLGGTPYPGMMVDSTFYNKIKSGYRMAKPDHATSEVYEIMVKCWNSEPEKRPSFYHLSEIVENLLPGQYKKSYEKIHLDFLKSDHPAVARMRVDSDNAYIGVTYKNEEDKLKDWEGGLDEQRLSADSGYIIPLPDIDPVPEEEDLGKRNRHSSQTSEESAIETGSSSSTFIKREDETIEDIDMMDDIGIDSSDLVEDSFLA Alanin C Cisteyin D Asparaginova kislota E Glutaminova kislota F Fenilalanin G Glicin H Gistidin I Izolejcin K Lizin L Lejcin M Metionin N Asparagin P Prolin Q Glutamin R Arginin S Serin T Treonin V Valin W Triptofan Y Tirozin Kodovanij genom bilok za funkciyami nalezhit do transferaz kinaz receptoriv bilkiv rozvitku tirozinovih proteyinkinaz fosfoproteyiniv Zadiyanij u takih biologichnih procesah yak vzayemodiya hazyayin virus hemotaksis polimorfizm alternativnij splajsing Bilok maye sajt dlya zv yazuvannya z ATF nukleotidami Lokalizovanij u klitinnij membrani Literatura red Claesson Welsh L Eriksson A Westermark B Heldin C H 1989 cDNA cloning and expression of the human A type platelet derived growth factor PDGF receptor establishes structural similarity to the B type PDGF receptor Proc Natl Acad Sci U S A 86 4917 4921 PubMed DOI 10 1073 pnas 86 13 4917 Kawagishi J Ku T 1995 Structure organization and transcription units of the human alpha platelet derived growth factor receptor gene PDGFRA Genomics 30 224 232 PubMed DOI 10 1006 geno 1995 9883 The status quality and expansion of the NIH full length cDNA project the Mammalian Gene Collection MGC Genome Res 14 2121 2127 2004 PubMed DOI 10 1101 gr 2596504 Griffin J H Leung J Bruner R J Caligiuri M A Briesewitz R 2003 Discovery of a fusion kinase in EOL 1 cells and idiopathic hypereosinophilic syndrome Proc Natl Acad Sci U S A 100 7830 7835 PubMed DOI 10 1073 pnas 0932698100 Yokote K Margolis B Heldin C H Claesson Welsh L 1996 Grb7 is a downstream signaling component of platelet derived growth factor alpha and beta receptors J Biol Chem 271 30942 30949 PubMed DOI 10 1074 jbc 271 48 30942 Bazenet C E Gelderloos J A Kazlauskas A 1996 Phosphorylation of tyrosine 720 in the platelet derived growth factor alpha receptor is required for binding of Grb2 and SHP 2 but not for activation of Ras or cell proliferation Mol Cell Biol 16 6926 6936 PubMed DOI 10 1128 MCB 16 12 6926Primitki red Zahvoryuvannya genetichno pov yazani z PDGFRA pereglyanuti redaguvati posilannya na VikiDanih Spoluki yaki fizichno vzayemodiyut z Platelet derived growth factor receptor alpha pereglyanuti redaguvati posilannya na VikiDanih Human PubMed Reference Mouse PubMed Reference HUGO Gene Nomenclature Commitee HGNC 8803 angl Arhiv originalu za 19 chervnya 2017 Procitovano 30 serpnya 2017 UniProt P16234 angl Arhiv originalu za 2 veresnya 2017 Procitovano 30 serpnya 2017 Div takozh red Hromosoma 4 nbsp Ce nezavershena stattya pro bilki Vi mozhete dopomogti proyektu vipravivshi abo dopisavshi yiyi Otrimano z https uk wikipedia org w index php title PDGFRA amp oldid 35692656
