PCSK9 angl Proprotein convertase subtilisin kexin type 9 bilok yakij koduyetsya odnojmennim genom roztashovanim u lyudej na korotkomu plechi 1 yi hromosomi 5 Dovzhina polipeptidnogo lancyuga bilka stanovit 692 aminokislot a molekulyarna masa 74 286 6 PCSK9Nayavni strukturiPDBPoshuk ortologiv PDBe RCSBSpisok kodiv PDB2P4E 2PMW 2QTW 2W2M 2W2N 2W2O 2W2P 2W2Q 2XTJ 3BPS 3GCW 3GCX 3H42 3M0C 3P5B 3P5C 3SQO 4K8R 4NE9 4NMX 4OV6IdentifikatoriSimvoliPCSK9 proprotein convertase subtilisin kexin type 9 FH3 HCHOLA3 LDLCQ1 NARC 1 NARC1 PC9 FHCL3Zovnishni ID OMIM 607786 MGI 2140260 HomoloGene 17790 GeneCards PCSK9Pov yazani genetichni zahvoryuvannyahypercholesterolemia autosomal dominant 3 simejna giperholesterinemiya 1 Reaguye na spolukuevolocumab Bococizumab 2 Ontologiya genaMolekulyarna funkciya apolipoprotein binding apolipoprotein receptor binding very low density lipoprotein particle binding low density lipoprotein particle binding protein self association sodium channel inhibitor activity low density lipoprotein particle receptor binding very low density lipoprotein particle receptor binding GO 0070122 peptidase activity GO 0001948 GO 0016582 protein binding serine type peptidase activity signaling receptor inhibitor activity serine type endopeptidase activity hydrolase activity RNA bindingKlitinna komponenta citoplazma endosoma late endosome rough endoplasmic reticulum kompleks Goldzhi klitinna membrana PCSK9 AnxA2 complex cell surface early endosome extrinsic component of external side of plasma membrane endoplazmatichnij retikulum perinuclear region of cytoplasm COPII coated ER to Golgi transport vesicle lizosoma PCSK9 LDLR complex extracellular region extracellular space lysosomal membrane endolysosome membrane endoplasmic reticulum lumenBiologichnij proces lipoprotein metabolic process Nejrogenez steroid metabolic process kidney development positive regulation of receptor internalization lipid metabolism negative regulation of low density lipoprotein particle clearance negative regulation of sodium ion transmembrane transporter activity regulation of low density lipoprotein particle receptor catabolic process cellular response to starvation regulation of neuron apoptotic process protein processing regulation of signaling receptor activity cholesterol metabolic process protein autoprocessing proteoliz positive regulation of neuron apoptotic process positive regulation of low density lipoprotein particle receptor catabolic process low density lipoprotein receptor particle metabolic process neuron differentiation cellular response to insulin stimulus lysosomal transport phospholipid metabolic process liver development cholesterol homeostasis triglyceride metabolic process negative regulation of receptor recycling GO 0097285 Apoptoz negative regulation of low density lipoprotein particle receptor binding negative regulation of low density lipoprotein receptor activity negative regulation of receptor mediated endocytosis involved in cholesterol transport low density lipoprotein particle receptor catabolic process low density lipoprotein particle clearance posttranslyacijna modifikaciya negative regulation of signaling receptor activityDzherela Amigo QuickGOOrtologiVidi Lyudina MishaEntrez255738 100102Ensembl ENSG00000169174 ENSMUSG00000044254UniProt Q8NBP7 Q80W65RefSeq mRNK NM 174936NM 153565RefSeq bilok NP 777596NP 705793Lokus UCSC Hr 1 55 04 55 06 MbHr 4 106 3 106 32 MbPubMed search 3 4 VikidaniDiv Red dlya lyudejDiv Red dlya mishej Poslidovnist aminokislot1020304050MGTVSSRRSWWPLPLLLLLLLLLGPAGARAQEDEDGDYEELVLALRSEEDGLAEAPEHGTTATFHRCAKDPWRLPGTYVVVLKEETHLSQSERTARRLQAQAARRGYLTKILHVFHGLLPGFLVKMSGDLLELALKLPHVDYIEEDSSVFAQSIPWNLERITPPRYRADEYQPPDGGSLVEVYLLDTSIQSDHREIEGRVMVTDFENVPEEDGTRFHRQASKCDSHGTHLAGVVSGRDAGVAKGASMRSLRVLNCQGKGTVSGTLIGLEFIRKSQLVQPVGPLVVLLPLAGGYSRVLNAACQRLARAGVVLVTAAGNFRDDACLYSPASAPEVITVGATNAQDQPVTLGTLGTNFGRCVDLFAPGEDIIGASSDCSTCFVSQSGTSQAAAHVAGIAAMMLSAEPELTLAELRQRLIHFSAKDVINEAWFPEDQRVLTPNLVAALPPSTHGAGWQLFCRTVWSAHSGPTRMATAVARCAPDEELLSCSSFSRSGKRRGERMEAQGGKLVCRAHNAFGGEGVYAIARCCLLPQANCSVHTAPPAEASMGTRVHCHQQGHVLTGCSSHWEVEDLGTHKPPVLRPRGQPNQCVGHREASIHASCCHAPGLECKVKEHGIPAPQEQVTVACEEGWTLTGCSALPGTSHVLGAYAVDNTCVVRSRDVSTTGSTSEGAVTAVAICCRSRHLAQASQELQA Alanin C Cisteyin D Asparaginova kislota E Glutaminova kislota F Fenilalanin G Glicin H Gistidin I Izolejcin K Lizin L Lejcin M Metionin N Asparagin P Prolin Q Glutamin R Arginin S Serin T Treonin V Valin W Triptofan Y Tirozin Kodovanij genom bilok za funkciyami nalezhit do gidrolaz proteaz serinovih proteaz Zadiyanij u takih biologichnih procesah yak apoptoz metabolizm lipidiv metabolizm holesterolu metabolizm steroyidiv metabolizm steroliv Bilok maye sajt dlya zv yazuvannya z ionom kalciyu Lokalizovanij u citoplazmi endoplazmatichnomu retikulumi lizosomi aparati goldzhi endosomah Takozh sekretovanij nazovni Literatura red Ding K McDonough S J Kullo I J 2007 Evidence for positive selection in the C terminal domain of the cholesterol metabolism gene PCSK9 based on phylogenetic analysis in 14 primate species PLoS ONE 2 E1098 E1098 PubMed DOI 10 1371 journal pone 0001098 Benjannet S Rhainds D Hamelin J Nassoury N Seidah N G 2006 The proprotein convertase PC PCSK9 is inactivated by furin and or PC5 6A functional consequences of natural mutations and post translational modifications J Biol Chem 281 30561 30572 PubMed DOI 10 1074 jbc M606495200 Jonas M C Costantini C Puglielli L 2008 PCSK9 is required for the disposal of non acetylated intermediates of the nascent membrane protein BACE1 EMBO Rep 9 916 922 PubMed DOI 10 1038 embor 2008 132 Mayer G Poirier S Seidah N G 2008 Annexin A2 is a C terminal PCSK9 binding protein that regulates endogenous low density lipoprotein receptor levels J Biol Chem 283 31791 31801 PubMed DOI 10 1074 jbc M805971200 Yamamoto T Lu C Ryan R O 2011 A two step binding model of PCSK9 interaction with the low density lipoprotein receptor J Biol Chem 286 5464 5470 PubMed DOI 10 1074 jbc M110 199042 Lopez D 2008 PCSK9 an enigmatic protease Biochim Biophys Acta 1781 184 191 PubMed DOI 10 1016 j bbalip 2008 01 003Primitki red Zahvoryuvannya genetichno pov yazani z PCSK9 pereglyanuti redaguvati posilannya na VikiDanih Spoluki yaki fizichno vzayemodiyut z PCSK9 pereglyanuti redaguvati posilannya na VikiDanih Human PubMed Reference Mouse PubMed Reference HUGO Gene Nomenclature Commitee HGNC 20001 angl Arhiv originalu za 10 sichnya 2015 Procitovano 23 serpnya 2017 UniProt Q8NBP7 angl Arhiv originalu za 8 veresnya 2017 Procitovano 23 serpnya 2017 Div takozh red Hromosoma 1 nbsp Ce nezavershena stattya pro bilki Vi mozhete dopomogti proyektu vipravivshi abo dopisavshi yiyi Otrimano z https uk wikipedia org w index php title PCSK9 amp oldid 38133059
