OAT angl Ornithine aminotransferase bilok yakij koduyetsya odnojmennim genom roztashovanim u lyudej na 10 j hromosomi 4 Dovzhina polipeptidnogo lancyuga bilka stanovit 439 aminokislot a molekulyarna masa 48 535 5 OATNayavni strukturiPDBPoshuk ortologiv PDBe RCSBSpisok kodiv PDB1GBN 1OAT 2BYJ 2BYL 2CAN 2OATIdentifikatoriSimvoliOAT GACR HOGA OATASE OKT ornithine aminotransferaseZovnishni ID OMIM 613349 MGI 97394 HomoloGene 231 GeneCards OATPov yazani genetichni zahvoryuvannyagyrate atrophy of the choroid 1 Ontologiya genaMolekulyarna funkciya katalitichna aktivnist identical protein binding pyridoxal phosphate binding transferase activity transaminase activity ornithine oxo acid transaminase activityKlitinna komponenta citoplazma mitohondrialnij matriks Nukleoplazma mitohondriyaBiologichnij proces L proline biosynthetic process zir cellular amino acid biosynthetic process protein hexamerization arginine catabolic process to proline via ornithine arginine catabolic process to glutamateDzherela Amigo QuickGOOrtologiVidi Lyudina MishaEntrez4942 18242Ensembl ENSG00000065154 ENSMUSG00000030934UniProt P04181 P29758RefSeq mRNK NM 000274NM 001171814NM 001322965NM 001322966NM 001322967NM 001322968NM 001322969NM 001322970NM 001322971NM 001322974NM 016978RefSeq bilok NP 000265NP 001165285NP 001309894NP 001309895NP 001309896NP 001309897NP 001309898NP 001309899NP 001309900NP 001309903NP 058674Lokus UCSC Hr 10 124 4 124 42 MbHr 7 132 16 132 18 MbPubMed search 2 3 VikidaniDiv Red dlya lyudejDiv Red dlya mishej Poslidovnist aminokislot1020304050MFSKLAHLQRFAVLSRGVHSSVASATSVATKKTVQGPPTSDDIFEREYKYGAHNYHPLPVALERGKGIYLWDVEGRKYFDFLSSYSAVNQGHCHPKIVNALKSQVDKLTLTSRAFYNNVLGEYEEYITKLFNYHKVLPMNTGVEAGETACKLARKWGYTVKGIQKYKAKIVFAAGNFWGRTLSAISSSTDPTSYDGFGPFMPGFDIIPYNDLPALERALQDPNVAAFMVEPIQGEAGVVVPDPGYLMGVRELCTRHQVLFIADEIQTGLARTGRWLAVDYENVRPDIVLLGKALSGGLYPVSAVLCDDDIMLTIKPGEHGSTYGGNPLGCRVAIAALEVLEEENLAENADKLGIILRNELMKLPSDVVTAVRGKGLLNAIVIKETKDWDAWKVCLRLRDNGLLAKPTHGDIIRFAPPLVIKEDELRESIEIINKTILSFA Alanin C Cisteyin D Asparaginova kislota E Glutaminova kislota F Fenilalanin G Glicin H Gistidin I Izolejcin K Lizin L Lejcin M Metionin N Asparagin P Prolin Q Glutamin R Arginin S Serin T Treonin V Valin W Triptofan Y Tirozin Kodovanij genom bilok za funkciyami nalezhit do transferaz aminotransferaz Zadiyanij u takih biologichnih procesah yak acetilyuvannya alternativnij splajsing Bilok maye sajt dlya zv yazuvannya z piridoksal fosfatom Lokalizovanij u mitohondriyi Literatura red Ramesh V Shaffer M M Allaire J M Shih V E Gusella J F 1986 Investigation of gyrate atrophy using a cDNA clone for human ornithine aminotransferase DNA 5 493 501 PubMed DOI 10 1089 dna 1 1986 5 493 Kobayashi T Nishii M Takagi Y Titani T Matsuzawa T 1989 Molecular cloning and nucleotide sequence analysis of mRNA for human kidney ornithine aminotransferase An examination of ornithine aminotransferase isozymes between liver and kidney FEBS Lett 255 300 304 PubMed DOI 10 1016 0014 5793 89 81110 X Zintz C B Inana G 1990 Analysis of the human ornithine aminotransferase gene family Exp Eye Res 50 759 770 PubMed DOI 10 1016 0014 4835 90 90126 F The status quality and expansion of the NIH full length cDNA project the Mammalian Gene Collection MGC Genome Res 14 2121 2127 2004 PubMed DOI 10 1101 gr 2596504 Simmaco M John R A Barra D Bossa F 1986 The primary structure of ornithine aminotransferase Identification of active site sequence and site of post translational proteolysis FEBS Lett 199 39 42 PubMed DOI 10 1016 0014 5793 86 81219 4 Shah S A Shen B W Brunger A T 1997 Human ornithine aminotransferase complexed with L canaline and gabaculine structural basis for substrate recognition Structure 5 1067 1075 PubMed DOI 10 1016 S0969 2126 97 00258 XPrimitki red Zahvoryuvannya genetichno pov yazani z OAT pereglyanuti redaguvati posilannya na VikiDanih Human PubMed Reference Mouse PubMed Reference HUGO Gene Nomenclature Commitee HGNC 8091 angl Procitovano 19 veresnya 2017 UniProt P04181 angl Arhiv originalu za 18 zhovtnya 2017 Procitovano 19 veresnya 2017 Div takozh red Hromosoma 10 nbsp Ce nezavershena stattya pro bilki Vi mozhete dopomogti proyektu vipravivshi abo dopisavshi yiyi Otrimano z https uk wikipedia org w index php title OAT amp oldid 35687474
