Laktotransferin angl Lactotransferrin bilok yakij koduyetsya genom LTF roztashovanim u lyudej na korotkomu plechi 3 yi hromosomi 3 Dovzhina polipeptidnogo lancyuga bilka stanovit 710 aminokislot a molekulyarna masa 78 182 4 LaktotransferinNayavni strukturiPDBPoshuk ortologiv PDBe RCSBSpisok kodiv PDB2PMS 1B0L 1BKA 1CB6 1DSN 1EH3 1FCK 1H43 1H44 1H45 1HSE 1L5T 1LCF 1LCT 1LFG 1LFH 1LFI 1LGB 1N76 1SQY 1U62 1VFD 1VFE 1XV4 1XV7 1Z6V 1Z6W 2BJJ 2DP4 2GMC 2GMD 2HD4IdentifikatoriSimvoliLTF GIG12 HEL110 HLF2 LF lactotransferrinZovnishni ID OMIM 150210 MGI 96837 HomoloGene 1754 GeneCards LTFOntologiya genaMolekulyarna funkciya iron ion binding DNA binding heparin binding protein serine threonine kinase activator activity zv yazuvannya z ionom metalu GO 0070122 peptidase activity GO 0001948 GO 0016582 protein binding serine type peptidase activity serine type endopeptidase activity hydrolase activity lipopolysaccharide binding cysteine type endopeptidase inhibitor activityKlitinna komponenta citoplazma secretory granule extracellular region cell surface specific granule phagocytic vesicle lumen ekzosoma klitinne yadro extracellular space specific granule lumen tertiary granule lumen GO 0009327 protein containing complexBiologichnij proces positive regulation of osteoblast proliferation GO 0009373 regulation of transcription DNA templated positive regulation of chondrocyte proliferation negative regulation of osteoclast development Osifikaciya regulation of tumor necrosis factor production negative regulation of viral process immune system process negative regulation of ATP dependent activity antibacterial humoral response bone morphogenesis iron ion homeostasis positive regulation of bone mineralization involved in bone maturation negative regulation of apoptotic process ion transport transcription DNA templated proteoliz positive regulation of protein serine threonine kinase activity negative regulation of single species biofilm formation in or on host organism negative regulation by host of viral process negative regulation of lipopolysaccharide mediated signaling pathway GO 0032657 regulation of cytokine production negative regulation of tumor necrosis factor ligand superfamily member 11 production retina homeostasis negative regulation of viral genome replication innate immune response in mucosa positive regulation of osteoblast differentiation humoral immune response defense response to bacterium positive regulation of NF kappaB transcription factor activity positive regulation of I kappaB kinase NF kappaB signaling positive regulation of toll like receptor 4 signaling pathway siderophore dependent iron import into cell antimicrobial humoral response neutrophil degranulation Vrodzhenij imunitet negative regulation of membrane potential antimicrobial humoral immune response mediated by antimicrobial peptide negative regulation of cysteine type endopeptidase activity GO 0015915 transport antifungal humoral responseDzherela Amigo QuickGOOrtologiVidi Lyudina MishaEntrez4057 17002Ensembl ENSG00000012223 ENSMUSG00000032496UniProt P02788 P08071RefSeq mRNK NM 002343NM 001199149NM 001321121NM 001321122NM 008522RefSeq bilok NP 001186078NP 001308050NP 001308051NP 002334NP 032548Lokus UCSC Hr 3 46 44 46 49 MbHr 9 110 85 110 87 MbPubMed search 1 2 VikidaniDiv Red dlya lyudejDiv Red dlya mishej Poslidovnist aminokislot1020304050MKLVFLVLLFLGALGLCLAGRRRSVQWCAVSQPEATKCFQWQRNMRKVRGPPVSCIKRDSPIQCIQAIAENRADAVTLDGGFIYEAGLAPYKLRPVAAEVYGTERQPRTHYYAVAVVKKGGSFQLNELQGLKSCHTGLRRTAGWNVPIGTLRPFLNWTGPPEPIEAAVARFFSASCVPGADKGQFPNLCRLCAGTGENKCAFSSQEPYFSYSGAFKCLRDGAGDVAFIRESTVFEDLSDEAERDEYELLCPDNTRKPVDKFKDCHLARVPSHAVVARSVNGKEDAIWNLLRQAQEKFGKDKSPKFQLFGSPSGQKDLLFKDSAIGFSRVPPRIDSGLYLGSGYFTAIQNLRKSEEEVAARRARVVWCAVGEQELRKCNQWSGLSEGSVTCSSASTTEDCIALVLKGEADAMSLDGGYVYTAGKCGLVPVLAENYKSQQSSDPDPNCVDRPVEGYLAVAVVRRSDTSLTWNSVKGKKSCHTAVDRTAGWNIPMGLLFNQTGSCKFDEYFSQSCAPGSDPRSNLCALCIGDEQGENKCVPNSNERYYGYTGAFRCLAENAGDVAFVKDVTVLQNTDGNNNEAWAKDLKLADFALLCLDGKRKPVTEARSCHLAMAPNHAVVSRMDKVERLKQVLLHQQAKFGRNGSDCPDKFCLFQSETKNLLFNDNTECLARLHGKTTYEKYLGPQYVAGITNLKKCSTSPLLEACEFLRKA Alanin C Cisteyin D Asparaginova kislota E Glutaminova kislota F Fenilalanin G Glicin H Gistidin I Izolejcin K Lizin L Lejcin M Metionin N Asparagin P Prolin Q Glutamin R Arginin S Serin T Treonin V Valin W Triptofan Y Tirozin Cej bilok za funkciyami nalezhit do gidrolaz proteaz serinovih proteaz antibiotikiv antimikrobnih bilkiv Zadiyanij u takih biologichnih procesah yak imunitet transkripciya regulyaciya transkripciyi transport ioniv transport zaliza transport osteogenez Bilok maye sajt dlya zv yazuvannya z ionami metaliv ionom zaliza DNK z molekuloyu geparinu Lokalizovanij u citoplazmi yadri Takozh sekretovanij nazovni Literatura red Rey M W Woloshuk S L de Boer H A Pieper F R 1990 Complete nucleotide sequence of human mammary gland lactoferrin Nucleic Acids Res 18 5288 5288 PubMed DOI 10 1093 nar 18 17 5288 Siebert P D Huang B C 1997 Identification of an alternative form of human lactoferrin mRNA that is expressed differentially in normal tissues and tumor derived cell lines Proc Natl Acad Sci U S A 94 2198 2203 PubMed DOI 10 1073 pnas 94 6 2198 The status quality and expansion of the NIH full length cDNA project the Mammalian Gene Collection MGC Genome Res 14 2121 2127 2004 PubMed DOI 10 1101 gr 2596504 Teng C T Liu Y Yang N Walmer D Panella T 1992 Differential molecular mechanism of the estrogen action that regulates lactoferrin gene in human and mouse Mol Endocrinol 6 1969 1981 PubMed DOI 10 1210 mend 6 11 1480183 Powell M J Ogden J E 1990 Nucleotide sequence of human lactoferrin cDNA Nucleic Acids Res 18 4013 4013 PubMed DOI 10 1093 nar 18 13 4013 Hunter H N Demcoe A R Jenssen H Gutteberg T J Vogel H J 2005 Human lactoferricin is partially folded in aqueous solution and is better stabilized in a membrane mimetic solvent Antimicrob Agents Chemother 49 3387 3395 PubMed DOI 10 1128 AAC 49 8 3387 3395 2005Primitki red Human PubMed Reference Mouse PubMed Reference HUGO Gene Nomenclature Commitee HGNC 6720 angl Arhiv originalu za 14 lipnya 2017 Procitovano 30 sichnya 2017 UniProt P02788 angl Arhiv originalu za 23 sichnya 2017 Procitovano 30 sichnya 2017 Div takozh red Hromosoma 3 nbsp Ce nezavershena stattya pro bilki Vi mozhete dopomogti proyektu vipravivshi abo dopisavshi yiyi Otrimano z https uk wikipedia org w 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