IKZF1 angl IKAROS family zinc finger 1 bilok yakij koduyetsya odnojmennim genom roztashovanim u lyudej na korotkomu plechi 7 yi hromosomi 4 Dovzhina polipeptidnogo lancyuga bilka stanovit 519 aminokislot a molekulyarna masa 57 528 5 IKZF1IdentifikatoriSimvoliIKZF1 Hs 54452 IK1 IKAROS LYF1 LyF 1 PPP1R92 PRO0758 ZNFN1A1 CVID13 IKAROS family zinc finger 1Zovnishni ID OMIM 603023 MGI 1342540 HomoloGene 55948 GeneCards IKZF1Pov yazani genetichni zahvoryuvannyaGostrij limfoblastnij lejkoz lymphoblastic leukemia pancytopenia due to IKZF1 mutations 1 Ontologiya genaMolekulyarna funkciya GO 0001131 GO 0001151 GO 0001130 GO 0001204 DNA binding transcription factor activity DNA binding GO 0001948 GO 0016582 protein binding zv yazuvannya z ionom metalu nucleic acid binding protein domain specific binding GO 0001200 GO 0001133 GO 0001201 DNA binding transcription factor activity RNA polymerase II specificKlitinna komponenta citoplazma klitinne yadro Nukleoplazma GO 0009327 protein containing complexBiologichnij proces erythrocyte differentiation klitinnij cikl multicellular organism development mesoderm development GO 0045996 negative regulation of transcription DNA templated GO 0009373 regulation of transcription DNA templated transcription DNA templated GO 0003257 GO 0010735 GO 1901228 GO 1900622 GO 1904488 positive regulation of transcription by RNA polymerase II lymphocyte differentiation protein heterooligomerization GO 0031497 GO 0006336 GO 0034724 GO 0001301 GO 0007580 GO 0034652 GO 0010847 chromatin organizationDzherela Amigo QuickGOShablon ekspresiyiBilshe danihOrtologiVidi Lyudina MishaEntrez10320 22778Ensembl ENSG00000185811 ENSMUSG00000018654UniProt Q13422 Q03267RefSeq mRNK NM 001220765NM 001220766NM 001220767NM 001220768NM 001220769NM 001220770NM 001220771NM 001220772NM 001220773NM 001220774NM 001220775NM 001220776NM 001291837NM 001291838NM 001291839NM 001291840NM 001291841NM 001291842NM 001291843NM 001291844NM 001291845NM 001291846NM 001291847NM 006060NM 001025597NM 001301863NM 001301865NM 001301866NM 001301868NM 009578RefSeq bilok NP 001207694NP 001207696NP 001207697NP 001207699NP 001207700NP 001278766NP 001278767NP 001278768NP 001278769NP 001278770NP 001278771NP 001278772NP 001278773NP 001278774NP 001278775NP 001278776NP 006051n dLokus UCSC Hr 7 50 3 50 41 MbHr 11 11 64 11 72 MbPubMed search 2 3 VikidaniDiv Red dlya lyudejDiv Red dlya mishej Poslidovnist aminokislot1020304050MDADEGQDMSQVSGKESPPVSDTPDEGDEPMPIPEDLSTTSGGQQSSKSDRVVASNVKVETQSDEENGRACEMNGEECAEDLRMLDASGEKMNGSHRDQGSSALSGVGGIRLPNGKLKCDICGIICIGPNVLMVHKRSHTGERPFQCNQCGASFTQKGNLLRHIKLHSGEKPFKCHLCNYACRRRDALTGHLRTHSVGKPHKCGYCGRSYKQRSSLEEHKERCHNYLESMGLPGTLYPVIKEETNHSEMAEDLCKIGSERSLVLDRLASNVAKRKSSMPQKFLGDKGLSDTPYDSSASYEKENEMMKSHVMDQAINNAINYLGAESLRPLVQTPPGGSEVVPVISPMYQLHKPLAEGTPRSNHSAQDSAVENLLLLSKAKLVPSEREASPSNSCQDSTDTESNNEEQRSGLIYLTNHIAPHARNGLSLKEEHRAYDLLRAASENSQDALRVVSTSGEQMKVYKCEHCRVLFLDHVMYTIHMGCHGFRDPFECNMCGYHSQDRYEFSSHITRGEHRFHMSA Alanin C Cisteyin D Asparaginova kislota E Glutaminova kislota F Fenilalanin G Glicin H Gistidin I Izolejcin K Lizin L Lejcin M Metionin N Asparagin P Prolin Q Glutamin R Arginin S Serin T Treonin V Valin Y Tirozin Kodovanij genom bilok za funkciyami nalezhit do represoriv aktivatoriv regulyatoriv hromatinu bilkiv rozvitku fosfoproteyiniv Zadiyanij u takih biologichnih procesah yak transkripciya regulyaciya transkripciyi klitinnij cikl alternativnij splajsing Bilok maye sajt dlya zv yazuvannya z ionami metaliv ionom cinku DNK Lokalizovanij u citoplazmi yadri Literatura red Nietfeld W Meyerhans A 1996 Cloning and sequencing of hIk 1 a cDNA encoding a human homologue of mouse Ikaros LyF 1 Immunol Lett 49 139 141 PubMed DOI 10 1016 0165 2478 95 02479 4 The status quality and expansion of the NIH full length cDNA project the Mammalian Gene Collection MGC Genome Res 14 2121 2127 2004 PubMed DOI 10 1101 gr 2596504 Perdomo J Holmes M Chong B Crossley M 2000 Eos and pegasus two members of the Ikaros family of proteins with distinct DNA binding activities J Biol Chem 275 38347 38354 PubMed DOI 10 1074 jbc M005457200Primitki red Zahvoryuvannya genetichno pov yazani z IKZF1 pereglyanuti redaguvati posilannya na VikiDanih Human PubMed Reference Mouse PubMed Reference HUGO Gene Nomenclature Commitee HGNC 13176 angl Arhiv originalu za 10 travnya 2017 Procitovano 7 veresnya 2017 UniProt Q13422 angl Arhiv originalu za 31 serpnya 2017 Procitovano 7 veresnya 2017 Div takozh red Hromosoma 7 nbsp Ce nezavershena stattya pro bilki Vi mozhete dopomogti proyektu vipravivshi abo dopisavshi yiyi Otrimano z https uk wikipedia org w index php title IKZF1 amp oldid 35645594
