ERBB2 angl Erb b2 receptor tyrosine kinase 2 bilok yakij koduyetsya odnojmennim genom roztashovanim u lyudej na korotkomu plechi 17 yi hromosomi 5 Dovzhina polipeptidnogo lancyuga bilka stanovit 1 255 aminokislot a molekulyarna masa 137 910 6 ERBB2Nayavni strukturiPDBPoshuk ortologiv PDBe RCSBSpisok kodiv PDB1MFG 1MFL 1MW4 1N8Z 1QR1 1S78 2A91 2JWA 2KS1 2L4K 3BE1 3H3B 3N85 3PP0 3RCD 3MZW 3WLW 3WSQ 4GFU 4HRL 4HRM 4HRN 2N2AIdentifikatoriSimvoliERBB2 CD340 HER 2 HER 2 neu HER2 MLN 19 NEU NGL TKR1 erb b2 receptor tyrosine kinase 2Zovnishni ID OMIM 164870 MGI 95410 HomoloGene 3273 GeneCards ERBB2shifr KF 2 7 10 1Pov yazani genetichni zahvoryuvannyabreast carcinoma disease of cellular proliferation nedribnoklitinna karcinoma legeniv 1 Reaguye na spolukuAfatinib canertinib dacomitinib lapatinib mubritinib neratinib Margetuximab dacomitinib Pertuzumab tucatinib bms 599626 bms 690514 cp 724714 cudc 101 poziotinib sapitinib varlitinib tesevatinib 2 Ontologiya genaMolekulyarna funkciya ErbB 3 class receptor binding transferase activity nucleotide binding protein kinase activity protein dimerization activity growth factor binding RNA polymerase I core binding kinase activity protein C terminus binding GO 0001948 GO 0016582 protein binding identical protein binding protein heterodimerization activity transmembrane receptor protein tyrosine kinase activity protein tyrosine kinase activity protein phosphatase binding ATP binding transmembrane signaling receptor activity phosphatidylinositol 4 5 bisphosphate 3 kinase activity receptor tyrosine kinaseKlitinna komponenta integral component of membrane membrana myelin sheath receptor complex klitinna membrana basolateral plasma membrane apical plasma membrane perinuclear region of cytoplasm endosome membrane GO 0016023 cytoplasmic vesicle klitinne yadro citoplazma gialoplazma integral component of plasma membrane basal plasma membraneBiologichnij proces positive regulation of protein phosphorylation peripheral nervous system development GO 0009373 regulation of transcription DNA templated negative regulation of immature T cell proliferation in thymus positive regulation of MAP kinase activity fosforilyuvannya transmembrane receptor protein tyrosine kinase signaling pathway positive regulation of epithelial cell proliferation cellular response to growth factor stimulus Zagoyennya ran oligodendrocyte differentiation regulation of angiogenesis positive regulation of translation transcription DNA templated nejrobiologiya rozvitku MAPK cascade protein phosphorylation heart development cell surface receptor signaling pathway GO 0032320 GO 0032321 GO 0032855 GO 0043089 GO 0032854 positive regulation of GTPase activity positive regulation of cell growth regulation of microtubule based process neuromuscular junction development regulation of ERK1 and ERK2 cascade myelination protein autophosphorylation phosphatidylinositol 3 kinase signaling positive regulation of transcription by RNA polymerase I proliferaciya positive regulation of transcription by RNA polymerase III motor neuron axon guidance enzyme linked receptor protein signaling pathway GO 0072468 Signalna transdukciya positive regulation of cell adhesion positive regulation of protein targeting to membrane ERBB2 signaling pathway phosphatidylinositol phosphate biosynthetic process GO 1901313 positive regulation of gene expression peptidyl tyrosine phosphorylation regulation of cell motility cellular response to epidermal growth factor stimulus GO 0044324 GO 0003256 GO 1901213 GO 0046019 GO 0046020 GO 1900094 GO 0061216 GO 0060994 GO 1902064 GO 0003258 GO 0072212 regulation of transcription by RNA polymerase II negative regulation of ERBB signaling pathway positive regulation of protein kinase B signaling negative regulation of signal transduction Diferenciaciya klitin negative regulation of apoptotic process positive regulation of ERK1 and ERK2 cascade GO 0007243 intracellular signal transduction positive regulation of cell population proliferation neuron differentiation positive regulation of MAPK cascadeDzherela Amigo QuickGOShablon ekspresiyiBilshe danihOrtologiVidi Lyudina MishaEntrez2064 13866Ensembl ENSG00000141736 ENSMUSG00000062312UniProt P04626 P70424RefSeq mRNK NM 001005862NM 001289936NM 001289937NM 001289938NM 004448NM 001003817NM 010152RefSeq bilok NP 001005862NP 001276865NP 001276866NP 001276867NP 004439NP 001369711NP 001369712NP 001369713NP 001369714NP 001369715NP 001369716NP 001369717NP 001369718NP 001369719NP 001369720NP 001369721NP 001369722NP 001369723NP 001369724NP 001369725NP 001369726NP 001369727NP 001369728NP 001369729NP 001369730NP 001369731NP 001369732NP 001369733NP 001369734NP 001369735NP 001003817Lokus UCSC Hr 17 39 69 39 73 MbHr 11 98 3 98 33 MbPubMed search 3 4 VikidaniDiv Red dlya lyudejDiv Red dlya mishej Poslidovnist aminokislot1020304050MELAALCRWGLLLALLPPGAASTQVCTGTDMKLRLPASPETHLDMLRHLYQGCQVVQGNLELTYLPTNASLSFLQDIQEVQGYVLIAHNQVRQVPLQRLRIVRGTQLFEDNYALAVLDNGDPLNNTTPVTGASPGGLRELQLRSLTEILKGGVLIQRNPQLCYQDTILWKDIFHKNNQLALTLIDTNRSRACHPCSPMCKGSRCWGESSEDCQSLTRTVCAGGCARCKGPLPTDCCHEQCAAGCTGPKHSDCLACLHFNHSGICELHCPALVTYNTDTFESMPNPEGRYTFGASCVTACPYNYLSTDVGSCTLVCPLHNQEVTAEDGTQRCEKCSKPCARVCYGLGMEHLREVRAVTSANIQEFAGCKKIFGSLAFLPESFDGDPASNTAPLQPEQLQVFETLEEITGYLYISAWPDSLPDLSVFQNLQVIRGRILHNGAYSLTLQGLGISWLGLRSLRELGSGLALIHHNTHLCFVHTVPWDQLFRNPHQALLHTANRPEDECVGEGLACHQLCARGHCWGPGPTQCVNCSQFLRGQECVEECRVLQGLPREYVNARHCLPCHPECQPQNGSVTCFGPEADQCVACAHYKDPPFCVARCPSGVKPDLSYMPIWKFPDEEGACQPCPINCTHSCVDLDDKGCPAEQRASPLTSIISAVVGILLVVVLGVVFGILIKRRQQKIRKYTMRRLLQETELVEPLTPSGAMPNQAQMRILKETELRKVKVLGSGAFGTVYKGIWIPDGENVKIPVAIKVLRENTSPKANKEILDEAYVMAGVGSPYVSRLLGICLTSTVQLVTQLMPYGCLLDHVRENRGRLGSQDLLNWCMQIAKGMSYLEDVRLVHRDLAARNVLVKSPNHVKITDFGLARLLDIDETEYHADGGKVPIKWMALESILRRRFTHQSDVWSYGVTVWELMTFGAKPYDGIPAREIPDLLEKGERLPQPPICTIDVYMIMVKCWMIDSECRPRFRELVSEFSRMARDPQRFVVIQNEDLGPASPLDSTFYRSLLEDDDMGDLVDAEEYLVPQQGFFCPDPAPGAGGMVHHRHRSSSTRSGGGDLTLGLEPSEEEAPRSPLAPSEGAGSDVFDGDLGMGAAKGLQSLPTHDPSPLQRYSEDPTVPLPSETDGYVAPLTCSPQPEYVNQPDVRPQPPSPREGPLPAARPAGATLERPKTLSPGKNGVVKDVFAFGGAVENPEYLTPQGGAAPQPHPPPAFSPAFDNLYYWDQDPPERGAPPSTFKGTPTAENPEYLGLDVPVA Alanin C Cisteyin D Asparaginova kislota E Glutaminova kislota F Fenilalanin G Glicin H Gistidin I Izolejcin K Lizin L Lejcin M Metionin N Asparagin P Prolin Q Glutamin R Arginin S Serin T Treonin V Valin W Triptofan Y Tirozin Kodovanij genom bilok za funkciyami nalezhit do transferaz kinaz receptoriv aktivatoriv tirozinovih proteyinkinaz fosfoproteyiniv Zadiyanij u takih biologichnih procesah yak transkripciya regulyaciya transkripciyi alternativnij splajsing Bilok maye sajt dlya zv yazuvannya z ATF nukleotidami Lokalizovanij u klitinnij membrani citoplazmi yadri membrani Literatura red The status quality and expansion of the NIH full length cDNA project the Mammalian Gene Collection MGC Genome Res 14 2121 2127 2004 PubMed DOI 10 1101 gr 2596504 Semba K Kamata N Toyoshima K Yamamoto T 1985 A v erbB related protooncogene c erbB 2 is distinct from the c erbB 1 epidermal growth factor receptor gene and is amplified in a human salivary gland adenocarcinoma Proc Natl Acad Sci U S A 82 6497 6501 PubMed DOI 10 1073 pnas 82 19 6497 King C R Kraus M H Aaronson S A 1985 Amplification of a novel v erbB related gene in a human mammary carcinoma Science 229 974 976 PubMed DOI 10 1126 science 2992089 Sarkar F H Ball D E Li Y W Crissman J D 1993 Molecular cloning and sequencing of an intron of Her 2 neu ERBB2 gene DNA Cell Biol 12 611 615 PubMed DOI 10 1089 dna 1993 12 611 Olayioye M A Beuvink I Horsch K Daly J M Hynes N E 1999 ErbB receptor induced activation of stat transcription factors is mediated by Src tyrosine kinases J Biol Chem 274 17209 17218 PubMed DOI 10 1074 jbc 274 24 17209 Swiercz J M Kuner R Offermanns S 2004 Plexin B1 RhoGEF mediated RhoA activation involves the receptor tyrosine kinase ErbB 2 J Cell Biol 165 869 880 PubMed DOI 10 1083 jcb 200312094Primitki red Zahvoryuvannya genetichno pov yazani z ERBB2 pereglyanuti redaguvati posilannya na VikiDanih Spoluki yaki fizichno vzayemodiyut z ERBB2 pereglyanuti redaguvati posilannya na VikiDanih Human PubMed Reference Mouse PubMed Reference HUGO Gene Nomenclature Commitee HGNC 3430 angl Arhiv originalu za 4 sichnya 2017 Procitovano 12 veresnya 2017 UniProt P04626 angl Arhiv originalu za 2 veresnya 2017 Procitovano 12 veresnya 2017 Div takozh red Hromosoma 17 nbsp Ce nezavershena stattya pro bilki Vi mozhete dopomogti proyektu vipravivshi abo dopisavshi yiyi Otrimano z https uk wikipedia org w index php title ERBB2 amp oldid 35413993
