CYP3A4 angl Cytochrome P450 family 3 subfamily A member 4 bilok yakij koduyetsya odnojmennim genom roztashovanim u lyudej na korotkomu plechi 7 yi hromosomi 4 Dovzhina polipeptidnogo lancyuga bilka stanovit 503 aminokislot a molekulyarna masa 57 343 5 CYP3A4Nayavni strukturiPDBPoshuk ortologiv PDBe RCSBSpisok kodiv PDB1TQN 1W0E 1W0F 1W0G 2J0D 2V0M 3NXU 3TJS 3UA1 4I3Q 4I4G 4I4H 4K9T 4K9U 4K9V 4K9W 4K9X 4NY4 5A1P 5A1R 4D6Z 4D75 4D78 4D7DIdentifikatoriSimvoliCYP3A4 CP33 CP34 CYP3A CYP3A3 CYPIIIA3 CYPIIIA4 HLP NF 25 P450C3 P450PCN1 cytochrome P450 family 3 subfamily A member 4 VDDR3Zovnishni ID OMIM 124010 HomoloGene 111391 GeneCards CYP3A4shifr KF 1 14 13 32Reaguye na spolukunefazodone ritonavir verapamil 1 Ontologiya genaMolekulyarna funkciya zv yazuvannya z ionom metalu heme binding caffeine oxidase activity testosterone 6 beta hydroxylase activity GO 0050602 oxidoreductase activity acting on paired donors with incorporation or reduction of molecular oxygen steroid binding vitamin D3 25 hydroxylase activity steroid hydroxylase activity vitamin D 24 hydroxylase activity oxygen binding enzyme binding iron ion binding oxidoreductase activity acting on paired donors with incorporation or reduction of molecular oxygen reduced flavin or flavoprotein as one donor and incorporation of one atom of oxygen monooxygenase activity oxidoreductase activity estrogen 16 alpha hydroxylase activityKlitinna komponenta citoplazma integral component of membrane membrana endoplazmatichnij retikulum organelle membrane endoplasmic reticulum membrane vnutrishnoklitinna membranna organelaBiologichnij proces xenobiotic metabolic process heterocycle metabolic process oxidative demethylation monoterpenoid metabolic process steroid catabolic process androgen metabolic process GO 1900774 GO 1900783 GO 1900795 GO 1901084 GO 1900780 GO 1900777 GO 1900771 GO 1901014 GO 1902180 GO 1900987 GO 1900990 alkaloid catabolic process vitamin D metabolic process lipid metabolism calcitriol biosynthetic process from calciol lipid hydroxylation steroid metabolic process long chain fatty acid biosynthetic processDzherela Amigo QuickGOShablon ekspresiyiBilshe danihOrtologiVidi Lyudina MishaEntrez1576 266682Ensembl ENSG00000160868 n dUniProt P08684 P05183RefSeq mRNK NM 001202855NM 001202856NM 001202857NM 017460NM 153312RefSeq bilok NP 001189784NP 059488NP 695224Lokus UCSC Hr 7 99 76 99 78 Mbn dPubMed search 2 3 VikidaniDiv Red dlya lyudejDiv Red dlya mishej Poslidovnist aminokislot1020304050MALIPDLAMETWLLLAVSLVLLYLYGTHSHGLFKKLGIPGPTPLPFLGNILSYHKGFCMFDMECHKKYGKVWGFYDGQQPVLAITDPDMIKTVLVKECYSVFTNRRPFGPVGFMKSAISIAEDEEWKRLRSLLSPTFTSGKLKEMVPIIAQYGDVLVRNLRREAETGKPVTLKDVFGAYSMDVITSTSFGVNIDSLNNPQDPFVENTKKLLRFDFLDPFFLSITVFPFLIPILEVLNICVFPREVTNFLRKSVKRMKESRLEDTQKHRVDFLQLMIDSQNSKETESHKALSDLELVAQSIIFIFAGYETTSSVLSFIMYELATHPDVQQKLQEEIDAVLPNKAPPTYDTVLQMEYLDMVVNETLRLFPIAMRLERVCKKDVEINGMFIPKGVVVMIPSYALHRDPKYWTEPEKFLPERFSKKNKDNIDPYIYTPFGSGPRNCIGMRFALMNMKLALIRVLQNFSFKPCKETQIPLKLSLGGLLQPEKPVVLKVESRDGTVSGAA Alanin C Cisteyin D Asparaginova kislota E Glutaminova kislota F Fenilalanin G Glicin H Gistidin I Izolejcin K Lizin L Lejcin M Metionin N Asparagin P Prolin Q Glutamin R Arginin S Serin T Treonin V Valin W Triptofan Y Tirozin Kodovanij genom bilok za funkciyeyu nalezhit do oksidoreduktaz Zadiyanij u takih biologichnih procesah yak metabolizm lipidiv metabolizm steroyidiv metabolizm steroliv Bilok maye sajt dlya zv yazuvannya z ionami metaliv ionom zaliza gemom NADF Lokalizovanij u membrani endoplazmatichnomu retikulumi mikrosomah Literatura RedaguvatiBeaune P H Umbenhauer D R Bork R W Lloyd R S Guengerich F P 1986 Isolation and sequence determination of a cDNA clone related to human cytochrome P 450 nifedipine oxidase Proc Natl Acad Sci U S A 83 8064 8068 PubMed DOI 10 1073 pnas 83 21 8064 Spurr N K Gough A C Stevenson K Wolf C R 1989 The human cytochrome P450 CYP3 locus assignment to chromosome 7q22 qter Hum Genet 81 171 174 PubMed DOI 10 1007 BF00293896 Finta C Zaphiropoulos P G 2002 Intergenic mRNA molecules resulting from trans splicing J Biol Chem 277 5882 5890 PubMed DOI 10 1074 jbc M109175200 Chen Q Wu J Yu Y 1998 Establishment of transgenic cell line CHL 3A4 and its metabolic activation Zhonghua Yu Fang Yi Xue Za Zhi 32 281 284 PubMed Shimada T Yamazaki H Mimura M Inui Y Guengerich F P 1994 Interindividual variations in human liver cytochrome P 450 enzymes involved in the oxidation of drugs carcinogens and toxic chemicals studies with liver microsomes of 30 Japanese and 30 Caucasians J Pharmacol Exp Ther 270 414 423 PubMed Zhao X J Kawashiro T Ishizaki T 1998 Mutual inhibition between quinine and etoposide by human liver microsomes Evidence for cytochrome P4503A4 involvement in their major metabolic pathways Drug Metab Dispos 26 188 191 PubMedPrimitki Redaguvati Spoluki yaki fizichno vzayemodiyut z CYP3A4 pereglyanuti redaguvati posilannya na VikiDanih Human PubMed Reference Mouse PubMed Reference HUGO Gene Nomenclature Commitee HGNC 2637 angl Arhiv originalu za 6 listopada 2015 Procitovano 7 veresnya 2017 UniProt P08684 angl Arhiv originalu za 31 serpnya 2017 Procitovano 7 veresnya 2017 Div takozh RedaguvatiHromosoma 7 nbsp Ce nezavershena stattya pro bilki Vi mozhete dopomogti proyektu vipravivshi abo dopisavshi yiyi Otrimano z https uk wikipedia org w index php title CYP3A4 amp oldid 35372532
