CTCF angl CCCTC binding factor bilok yakij koduyetsya odnojmennim genom roztashovanim u lyudej na korotkomu plechi 16 yi hromosomi 4 Dovzhina polipeptidnogo lancyuga bilka stanovit 727 aminokislot a molekulyarna masa 82 785 5 CTCFNayavni strukturiPDBPoshuk ortologiv PDBe RCSBSpisok kodiv PDB1X6H 2CT1IdentifikatoriSimvoliCTCF MRD21 CCCTC binding factor FAP108 CFAP108Zovnishni ID OMIM 604167 MGI 109447 HomoloGene 4786 GeneCards CTCFPov yazani genetichni zahvoryuvannyaautosomal dominant non syndromic intellectual disability 21 syndromic intellectual disability 1 Ontologiya genaMolekulyarna funkciya DNA binding GO 0001106 transcription corepressor activity GO 0001131 GO 0001151 GO 0001130 GO 0001204 DNA binding transcription factor activity zinc ion binding zv yazuvannya z ionom metalu chromatin insulator sequence binding GO 0000980 RNA polymerase II cis regulatory region sequence specific DNA binding GO 0001078 GO 0001214 GO 0001206 DNA binding transcription repressor activity RNA polymerase II specific GO 0001948 GO 0016582 protein binding nucleic acid binding GO 0001200 GO 0001133 GO 0001201 DNA binding transcription factor activity RNA polymerase II specific sequence specific DNA binding GO 0001077 GO 0001212 GO 0001213 GO 0001211 GO 0001205 DNA binding transcription activator activity RNA polymerase II specific chromatin bindingKlitinna komponenta Nukleoplazma hromosoma Yaderce centromera condensed chromosome klitinne yadroBiologichnij proces GO 0009373 regulation of transcription DNA templated Epigenetichne uspadkuvannya regulation of centromeric sister chromatid cohesion chromosome segregation transcription DNA templated GO 0060469 GO 0009371 positive regulation of transcription DNA templated GO 0045996 negative regulation of transcription DNA templated protein localization to chromosome centromeric region negative regulation of cell population proliferation GO 0031497 GO 0006336 GO 0034724 GO 0001301 GO 0007580 GO 0034652 GO 0010847 chromatin organization GO 1901227 negative regulation of transcription by RNA polymerase II GO 1901313 positive regulation of gene expression Metilyuvannya DNK regulation of gene expression by genetic imprinting maintenance of DNA methylation negative regulation of gene expression regulation of histone methylation regulation of histone acetylation GO 0003257 GO 0010735 GO 1901228 GO 1900622 GO 1904488 positive regulation of transcription by RNA polymerase IIDzherela Amigo QuickGOShablon ekspresiyiBilshe danihOrtologiVidi Lyudina MishaEntrez10664 13018Ensembl ENSG00000102974 ENSMUSG00000005698UniProt P49711 Q61164RefSeq mRNK NM 001191022NM 006565NM 001363916NM 181322NM 001358924RefSeq bilok NP 001177951NP 006556NP 001350845NP 851839NP 001345853NP 001390652NP 001390653NP 001390654NP 001390655NP 001390656NP 001390657NP 001390658NP 001390659NP 001390660NP 001390661Lokus UCSC Hr 16 67 56 67 64 MbHr 8 105 64 105 68 MbPubMed search 2 3 VikidaniDiv Red dlya lyudejDiv Red dlya mishej Poslidovnist aminokislot1020304050MEGDAVEAIVEESETFIKGKERKTYQRRREGGQEEDACHLPQNQTDGGEVVQDVNSSVQMVMMEQLDPTLLQMKTEVMEGTVAPEAEAAVDDTQIITLQVVNMEEQPINIGELQLVQVPVPVTVPVATTSVEELQGAYENEVSKEGLAESEPMICHTLPLPEGFQVVKVGANGEVETLEQGELPPQEDPSWQKDPDYQPPAKKTKKTKKSKLRYTEEGKDVDVSVYDFEEEQQEGLLSEVNAEKVVGNMKPPKPTKIKKKGVKKTFQCELCSYTCPRRSNLDRHMKSHTDERPHKCHLCGRAFRTVTLLRNHLNTHTGTRPHKCPDCDMAFVTSGELVRHRRYKHTHEKPFKCSMCDYASVEVSKLKRHIRSHTGERPFQCSLCSYASRDTYKLKRHMRTHSGEKPYECYICHARFTQSGTMKMHILQKHTENVAKFHCPHCDTVIARKSDLGVHLRKQHSYIEQGKKCRYCDAVFHERYALIQHQKSHKNEKRFKCDQCDYACRQERHMIMHKRTHTGEKPYACSHCDKTFRQKQLLDMHFKRYHDPNFVPAAFVCSKCGKTFTRRNTMARHADNCAGPDGVEGENGGETKKSKRGRKRKMRSKKEDSSDSENAEPDLDDNEDEEEPAVEIEPEPEPQPVTPAPPPAKKRRGRPPGRTNQPKQNQPTAIIQVEDQNTGAIENIIVEVKKEPDAEPAEGEEEEAQPAATDAPNGDLTPEMILSMMDRA Alanin C Cisteyin D Asparaginova kislota E Glutaminova kislota F Fenilalanin G Glicin H Gistidin I Izolejcin K Lizin L Lejcin M Metionin N Asparagin P Prolin Q Glutamin R Arginin S Serin T Treonin V Valin W Triptofan Y Tirozin Kodovanij genom bilok za funkciyami nalezhit do represoriv aktivatoriv regulyatoriv hromatinu fosfoproteyiniv Zadiyanij u takih biologichnih procesah yak transkripciya regulyaciya transkripciyi rozhodzhennya hromosom acetilyuvannya alternativnij splajsing Bilok maye sajt dlya zv yazuvannya z ionami metaliv ionom cinku DNK Lokalizovanij u yadri hromosomah centromerah Literatura RedaguvatiThe status quality and expansion of the NIH full length cDNA project the Mammalian Gene Collection MGC Genome Res 14 2121 2127 2004 PubMed DOI 10 1101 gr 2596504 Vostrov A A Quitschke W W 1997 The zinc finger protein CTCF binds to the APBbeta domain of the amyloid beta protein precursor promoter Evidence for a role in transcriptional activation J Biol Chem 272 33353 33359 PubMed DOI 10 1074 jbc 272 52 33353 Klenova E M Morse H C III Ohlsson R Lobanenkov V V 2002 The novel BORIS CTCF gene family is uniquely involved in the epigenetics of normal biology and cancer Semin Cancer Biol 12 399 414 PubMed DOI 10 1016 S1044 579X 02 00060 3 Chao W Huynh K D Spencer R J Davidow L S Lee J T 2002 CTCF a candidate trans acting factor for X inactivation choice Science 295 345 347 PubMed DOI 10 1126 science 1065982 Ishihara K Oshimura M Nakao M 2006 CTCF dependent chromatin insulator is linked to epigenetic remodeling Mol Cell 23 733 742 PubMed DOI 10 1016 j molcel 2006 08 008 Majumder P Gomez J A Chadwick B P Boss J M 2008 The insulator factor CTCF controls MHC class II gene expression and is required for the formation of long distance chromatin interactions J Exp Med 205 785 798 PubMed DOI 10 1084 jem 20071843Primitki Redaguvati Zahvoryuvannya genetichno pov yazani z CTCF pereglyanuti redaguvati posilannya na VikiDanih Human PubMed Reference Mouse PubMed Reference HUGO Gene Nomenclature Commitee HGNC 13723 angl Arhiv originalu za 12 zhovtnya 2018 Procitovano 11 veresnya 2017 UniProt P49711 angl Arhiv originalu za 2 veresnya 2017 Procitovano 11 veresnya 2017 Div takozh RedaguvatiHromosoma 16 nbsp Ce nezavershena stattya pro bilki Vi mozhete dopomogti proyektu vipravivshi abo dopisavshi yiyi Otrimano z https uk wikipedia org w index php title CTCF amp oldid 35372045
