CDH2 angl Cadherin 2 bilok yakij koduyetsya odnojmennim genom roztashovanim u lyudej na korotkomu plechi 18 yi hromosomi 4 Dovzhina polipeptidnogo lancyuga bilka stanovit 906 aminokislot a molekulyarna masa 99 809 5 CDH2Nayavni strukturiPDBPoshuk ortologiv PDBe RCSBSpisok kodiv PDB1NCG 1NCH 1NCI 1NCJ 1OP4 2QVI 3Q2W 4NUM 4NUP 4NUQIdentifikatoriSimvoliCDH2 CD325 CDHN CDw325 NCAD cadherin 2 ACOGS ARVD14Zovnishni ID OMIM 114020 MGI 88355 HomoloGene 20424 GeneCards CDH2Pov yazani genetichni zahvoryuvannyaozhirinnya 1 Ontologiya genaMolekulyarna funkciya calcium ion binding gamma catenin binding zv yazuvannya z ionom metalu GO 0001948 GO 0016582 protein binding enzyme binding protein phosphatase binding alpha catenin binding protein kinase binding beta catenin binding identical protein binding cytoskeletal protein binding protein homodimerization activity cadherin bindingKlitinna komponenta citoplazma integral component of membrane membrana intercalated disc cell cell junction focal adhesion plasma membrane raft Adgezivni kontakti klitinna membrana sinaps basolateral plasma membrane apical plasma membrane cortical actin cytoskeleton catenin complex fascia adherens ekzosoma lamellipodium GO 0097483 GO 0097481 Postsinaptichne ushilnennya Sarkolema endoplasmic reticulum lumen cell surface Mizhklitinni kontakti GO 0005578 Pozaklitinna matricya integral component of plasma membrane neuron projection apical part of cell collagen containing extracellular matrix integral component of presynaptic active zone membrane integral component of postsynaptic specialization membraneBiologichnij proces calcium dependent cell cell adhesion via plasma membrane cell adhesion molecules heterophilic cell cell adhesion via plasma membrane cell adhesion molecules blood vessel morphogenesis homeostasis of number of cells positive regulation of muscle cell differentiation regulation of postsynaptic density protein 95 clustering glial cell differentiation neuroepithelial cell differentiation cell cell adhesion mediated by cadherin radial glial cell differentiation neuronal stem cell population maintenance regulation of oligodendrocyte progenitor proliferation telencephalon development neuroligin clustering involved in postsynaptic membrane assembly positive regulation of synaptic vesicle clustering adgeziya klitin regulation of signal transduction cerebral cortex development striated muscle cell differentiation adherens junction organization cell migration negative regulation of canonical Wnt signaling pathway positive regulation of MAPK cascade homophilic cell adhesion via plasma membrane adhesion molecules brain morphogenesis posttranslyacijna modifikaciya protein localization to plasma membrane GO 0000767 cell morphogenesis cell cell junction assembly synapse assembly regulation of axonogenesis regulation of synaptic transmission glutamatergic cell cell adhesionDzherela Amigo QuickGOShablon ekspresiyiBilshe danihOrtologiVidi Lyudina MishaEntrez1000 12558Ensembl ENSG00000170558 ENSMUSG00000024304UniProt P19022 P15116RefSeq mRNK NM 001308176NM 001792NM 007664RefSeq bilok NP 001295105NP 001783NP 001783 2NP 031690Lokus UCSC Hr 18 27 93 28 18 MbHr 18 16 72 16 94 MbPubMed search 2 3 VikidaniDiv Red dlya lyudejDiv Red dlya mishej Poslidovnist aminokislot1020304050MCRIAGALRTLLPLLAALLQASVEASGEIALCKTGFPEDVYSAVLSKDVHEGQPLLNVKFSNCNGKRKVQYESSEPADFKVDEDGMVYAVRSFPLSSEHAKFLIYAQDKETQEKWQVAVKLSLKPTLTEESVKESAEVEEIVFPRQFSKHSGHLQRQKRDWVIPPINLPENSRGPFPQELVRIRSDRDKNLSLRYSVTGPGADQPPTGIFIINPISGQLSVTKPLDREQIARFHLRAHAVDINGNQVENPIDIVINVIDMNDNRPEFLHQVWNGTVPEGSKPGTYVMTVTAIDADDPNALNGMLRYRIVSQAPSTPSPNMFTINNETGDIITVAAGLDREKVQQYTLIIQATDMEGNPTYGLSNTATAVITVTDVNDNPPEFTAMTFYGEVPENRVDIIVANLTVTDKDQPHTPAWNAVYRISGGDPTGRFAIQTDPNSNDGLVTVVKPIDFETNRMFVLTVAAENQVPLAKGIQHPPQSTATVSVTVIDVNENPYFAPNPKIIRQEEGLHAGTMLTTFTAQDPDRYMQQNIRYTKLSDPANWLKIDPVNGQITTIAVLDRESPNVKNNIYNATFLASDNGIPPMSGTGTLQIYLLDINDNAPQVLPQEAETCETPDPNSINITALDYDIDPNAGPFAFDLPLSPVTIKRNWTITRLNGDFAQLNLKIKFLEAGIYEVPIIITDSGNPPKSNISILRVKVCQCDSNGDCTDVDRIVGAGLGTGAIIAILLCIIILLILVLMFVVWMKRRDKERQAKQLLIDPEDDVRDNILKYDEEGGGEEDQDYDLSQLQQPDTVEPDAIKPVGIRRMDERPIHAEPQYPVRSAAPHPGDIGDFINEGLKAADNDPTAPPYDSLLVFDYEGSGSTAGSLSSLNSSSSGGEQDYDYLNDWGPRFKKLADMYGGGDDA Alanin C Cisteyin D Asparaginova kislota E Glutaminova kislota F Fenilalanin G Glicin H Gistidin I Izolejcin K Lizin L Lejcin M Metionin N Asparagin P Prolin Q Glutamin R Arginin S Serin T Treonin V Valin W Triptofan Y Tirozin Kodovanij genom bilok za funkciyeyu nalezhit do fosfoproteyiniv Zadiyanij u takih biologichnih procesah yak klitinna adgeziya alternativnij splajsing Bilok maye sajt dlya zv yazuvannya z ionami metaliv ionom kalciyu Lokalizovanij u klitinnij membrani membrani klitinnih kontaktah Literatura red Reid R A Hemperly J J 1990 Human N cadherin nucleotide and deduced amino acid sequence Nucleic Acids Res 18 5896 5896 PubMed DOI 10 1093 nar 18 19 5896 The status quality and expansion of the NIH full length cDNA project the Mammalian Gene Collection MGC Genome Res 14 2121 2127 2004 PubMed DOI 10 1101 gr 2596504 Wallis J A Fox M Walsh F S 1994 Structure of the human N cadherin gene YAC analysis and fine chromosomal mapping to 18q11 2 Genomics 22 172 179 PubMed DOI 10 1006 geno 1994 1358 Bhatt A S Erdjument Bromage H Tempst P Craik C S Moasser M M 2005 Adhesion signaling by a novel mitotic substrate of src kinases Oncogene 24 5333 5343 PubMed DOI 10 1038 sj onc 1208582 Salomon D Ayalon O Patel King R Hynes R O Geiger B 1992 Extrajunctional distribution of N cadherin in cultured human endothelial cells J Cell Sci 102 7 17 PubMedPrimitki red Zahvoryuvannya genetichno pov yazani z CDH2 pereglyanuti redaguvati posilannya na VikiDanih Human PubMed Reference Mouse PubMed Reference HUGO Gene Nomenclature Commitee HGNC 1759 angl Procitovano 12 veresnya 2017 UniProt P19022 angl Arhiv originalu za 8 veresnya 2017 Procitovano 12 veresnya 2017 Div takozh red Hromosoma 18 nbsp Ce nezavershena stattya pro bilki Vi mozhete dopomogti proyektu vipravivshi abo dopisavshi yiyi Otrimano z https uk wikipedia org w index php title CDH2 amp oldid 35582429
