AXIN1 angl Axin 1 bilok yakij koduyetsya odnojmennim genom roztashovanim u lyudej na korotkomu plechi 16 yi hromosomi 4 Dovzhina polipeptidnogo lancyuga bilka stanovit 862 aminokislot a molekulyarna masa 95 635 5 AXIN1Nayavni strukturiPDBPoshuk ortologiv PDBe RCSBSpisok kodiv PDB1DK8 1EMU 1O9U 3ZDI 4B7T 4NM0 4NM3 4NM5 4NM7 4NU1IdentifikatoriSimvoliAXIN1 AXIN PPP1R49 axin 1Zovnishni ID OMIM 603816 MGI 1096327 HomoloGene 2614 GeneCards AXIN1Pov yazani genetichni zahvoryuvannyadipygus liver carcinoma 1 Ontologiya genaMolekulyarna funkciya beta catenin binding protein homodimerization activity I SMAD binding GO 0005097 GO 0005099 GO 0005100 GTPase activator activity GO 0001948 GO 0016582 protein binding enzyme binding signaling receptor complex adaptor activity SMAD binding ubiquitin protein ligase binding GO 0032947 molecular adaptor activity protein kinase binding armadillo repeat domain binding identical protein binding signaling adaptor activityKlitinna komponenta citoplazma gialoplazma lateral plasma membrane membrana klitinna membrana perinuclear region of cytoplasm GO 0016023 cytoplasmic vesicle klitinne yadro beta catenin destruction complex cell peripheryBiologichnij proces forebrain anterior posterior pattern specification negative regulation of fat cell differentiation positive regulation of protein phosphorylation olfactory placode formation GO 1903364 positive regulation of protein catabolic process positive regulation of canonical Wnt signaling pathway embryonic eye morphogenesis negative regulation of Wnt signaling pathway positive regulation of JNK cascade negative regulation of transcription elongation from RNA polymerase II promoter positive regulation of peptidyl serine phosphorylation GO 0060469 GO 0009371 positive regulation of transcription DNA templated multicellular organism development lens placode formation determination of left right symmetry canonical Wnt signaling pathway involved in neural plate anterior posterior pattern formation positive regulation of ubiquitin protein transferase activity positive regulation of peptidyl threonine phosphorylation positive regulation of ubiquitin dependent protein catabolic process cytoplasmic microtubule organization canonical Wnt signaling pathway embryonic skeletal joint morphogenesis axial mesoderm formation positive regulation of protein ubiquitination activation of protein kinase activity muscle cell development Wnt activated signaling pathway involved in forebrain neuron fate commitment negative regulation of canonical Wnt signaling pathway GO 0072468 Signalna transdukciya GO 0097285 Apoptoz beta catenin destruction complex disassembly GO 0032320 GO 0032321 GO 0032855 GO 0043089 GO 0032854 positive regulation of GTPase activity Wnt signaling pathway beta catenin destruction complex assembly regulation of Wnt signaling pathway regulation of intracellular estrogen receptor signaling pathwayDzherela Amigo QuickGOShablon ekspresiyiBilshe danihOrtologiVidi Lyudina MishaEntrez8312 12005Ensembl ENSG00000103126 ENSMUSG00000024182UniProt O15169 O35625RefSeq mRNK NM 003502NM 181050NM 001159598NM 009733NM 001394381NM 001394382NM 001394389RefSeq bilok NP 003493NP 851393NP 001153070NP 033863NP 001381310NP 001381311NP 001381318Lokus UCSC Hr 16 0 29 0 35 MbHr 17 26 36 26 41 MbPubMed search 2 3 VikidaniDiv Red dlya lyudejDiv Red dlya mishej Poslidovnist aminokislot1020304050MNIQEQGFPLDLGASFTEDAPRPPVPGEEGELVSTDPRPASYSFCSGKGVGIKGETSTATPRRSDLDLGYEPEGSASPTPPYLKWAESLHSLLDDQDGISLFRTFLKQEGCADLLDFWFACTGFRKLEPCDSNEEKRLKLARAIYRKYILDNNGIVSRQTKPATKSFIKGCIMKQLIDPAMFDQAQTEIQATMEENTYPSFLKSDIYLEYTRTGSESPKVCSDQSSGSGTGKGISGYLPTLNEDEEWKCDQDMDEDDGRDAAPPGRLPQKLLLETAAPRVSSSRRYSEGREFRYGSWREPVNPYYVNAGYALAPATSANDSEQQSLSSDADTLSLTDSSVDGIPPYRIRKQHRREMQESVQVNGRVPLPHIPRTYRVPKEVRVEPQKFAEELIHRLEAVQRTREAEEKLEERLKRVRMEEEGEDGDPSSGPPGPCHKLPPAPAWHHFPPRCVDMGCAGLRDAHEENPESILDEHVQRVLRTPGRQSPGPGHRSPDSGHVAKMPVALGGAASGHGKHVPKSGAKLDAAGLHHHRHVHHHVHHSTARPKEQVEAEATRRAQSSFAWGLEPHSHGARSRGYSESVGAAPNASDGLAHSGKVGVACKRNAKKAESGKSASTEVPGASEDAEKNQKIMQWIIEGEKEISRHRRTGHGSSGTRKPQPHENSRPLSLEHPWAGPQLRTSVQPSHLFIQDPTMPPHPAPNPLTQLEEARRRLEEEEKRASRAPSKQRYVQEVMRRGRACVRPACAPVLHVVPAVSDMELSETETRSQRKVGGGSAQPCDSIVVAYYFCGEPIPYRTLVRGRAVTLGQFKELLTKKGSYRYYFKKVSDEFDCGVVFEEVREDEAVLPVFEEKIIGKVEKVDA Alanin C Cisteyin D Asparaginova kislota E Glutaminova kislota F Fenilalanin G Glicin H Gistidin I Izolejcin K Lizin L Lejcin M Metionin N Asparagin P Prolin Q Glutamin R Arginin S Serin T Treonin V Valin W Triptofan Y Tirozin Kodovanij genom bilok za funkciyami nalezhit do bilkiv rozvitku fosfoproteyiniv Zadiyanij u takih biologichnih procesah yak apoptoz signalnij shlyah Wnt alternativnij splajsing Lokalizovanij u klitinnij membrani citoplazmi yadri membrani Literatura red The status quality and expansion of the NIH full length cDNA project the Mammalian Gene Collection MGC Genome Res 14 2121 2127 2004 PubMed DOI 10 1101 gr 2596504 Hsu W Zeng L Costantini F 1999 Identification of a domain of Axin that binds to the serine threonine protein phosphatase 2A and a self binding domain J Biol Chem 274 3439 3445 PubMed DOI 10 1074 jbc 274 6 3439 Kusano S Raab Traub N 2002 I mfa domain proteins interact with Axin and affect its regulation of the Wnt and c Jun N terminal kinase signaling pathways Mol Cell Biol 22 6393 6405 PubMed DOI 10 1128 MCB 22 18 6393 6405 2002 Howe P H 2003 Regulation of the Wnt signaling pathway by disabled 2 Dab2 EMBO J 22 3084 3094 PubMed DOI 10 1093 emboj cdg286 Kim M J Chia I V Costantini F 2008 SUMOylation target sites at the C terminus protect Axin from ubiquitination and confer protein stability FASEB J 22 3785 3794 PubMed DOI 10 1096 fj 08 113910 Spink K E Polakis P Weis W I 2000 Structural basis of the axin adenomatous polyposis coli interaction EMBO J 19 2270 2279 PubMed DOI 10 1093 emboj 19 10 2270Primitki red Zahvoryuvannya genetichno pov yazani z AXIN1 pereglyanuti redaguvati posilannya na VikiDanih Human PubMed Reference Mouse PubMed Reference HUGO Gene Nomenclature Commitee HGNC 903 angl Arhiv originalu za 23 veresnya 2017 Procitovano 11 veresnya 2017 UniProt O15169 angl Arhiv originalu za 19 veresnya 2017 Procitovano 11 veresnya 2017 Div takozh red Hromosoma 16 nbsp Ce nezavershena stattya pro bilki Vi mozhete dopomogti proyektu vipravivshi abo dopisavshi yiyi Otrimano z https uk wikipedia org w index php title AXIN1 amp oldid 40462005
