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APC ген APC англ APC WNT signaling pathway regulator білок який кодується однойменним геном розташованим у людей на коро

APC (ген)

APC (англ. APC, WNT signaling pathway regulator) – білок, який кодується однойменним геном, розташованим у людей на короткому плечі 5-ї хромосоми. Довжина поліпептидного ланцюга білка становить 2 843 амінокислот, а молекулярна маса — 311 646.

APC
Наявні структури
PDBПошук ортологів: PDBe RCSB
Ідентифікатори
Символи APC, BTPS2, DP2, DP2.5, DP3, GS, PPP1R46, adenomatous polyposis coli, WNT signaling pathway regulator, Genes
Зовнішні ІД OMIM: 611731 MGI: 88039 HomoloGene: 30950 GeneCards: APC
Пов'язані генетичні захворювання
APC-related attenuated familial adenomatous polyposis, liver carcinoma, large intestine adenocarcinoma, large intestine cancer, desmoid disease, hereditary, синдром Ґарднера, familial adenomatous polyposis
Шаблон експресії
Більше даних
Ортологи
Види Людина Миша
Entrez
324
11789
Ensembl
UniProt
RefSeq (мРНК)
RefSeq (білок)
н/д
Локус (UCSC) н/д Хр. 18: 34.22 – 34.32 Mb
PubMed search
Вікідані
Див./Ред. для людейДив./Ред. для мишей
Послідовність амінокислот
1020304050
MAAASYDQLLKQVEALKMENSNLRQELEDNSNHLTKLETEASNMKEVLKQ
LQGSIEDEAMASSGQIDLLERLKELNLDSSNFPGVKLRSKMSLRSYGSRE
GSVSSRSGECSPVPMGSFPRRGFVNGSRESTGYLEELEKERSLLLADLDK
EEKEKDWYYAQLQNLTKRIDSLPLTENFSLQTDMTRRQLEYEARQIRVAM
EEQLGTCQDMEKRAQRRIARIQQIEKDILRIRQLLQSQATEAERSSQNKH
ETGSHDAERQNEGQGVGEINMATSGNGQGSTTRMDHETASVLSSSSTHSA
PRRLTSHLGTKVEMVYSLLSMLGTHDKDDMSRTLLAMSSSQDSCISMRQS
GCLPLLIQLLHGNDKDSVLLGNSRGSKEARARASAALHNIIHSQPDDKRG
RREIRVLHLLEQIRAYCETCWEWQEAHEPGMDQDKNPMPAPVEHQICPAV
CVLMKLSFDEEHRHAMNELGGLQAIAELLQVDCEMYGLTNDHYSITLRRY
AGMALTNLTFGDVANKATLCSMKGCMRALVAQLKSESEDLQQVIASVLRN
LSWRADVNSKKTLREVGSVKALMECALEVKKESTLKSVLSALWNLSAHCT
ENKADICAVDGALAFLVGTLTYRSQTNTLAIIESGGGILRNVSSLIATNE
DHRQILRENNCLQTLLQHLKSHSLTIVSNACGTLWNLSARNPKDQEALWD
MGAVSMLKNLIHSKHKMIAMGSAAALRNLMANRPAKYKDANIMSPGSSLP
SLHVRKQKALEAELDAQHLSETFDNIDNLSPKASHRSKQRHKQSLYGDYV
FDTNRHDDNRSDNFNTGNMTVLSPYLNTTVLPSSSSSRGSLDSSRSEKDR
SLERERGIGLGNYHPATENPGTSSKRGLQISTTAAQIAKVMEEVSAIHTS
QEDRSSGSTTELHCVTDERNALRRSSAAHTHSNTYNFTKSENSNRTCSMP
YAKLEYKRSSNDSLNSVSSSDGYGKRGQMKPSIESYSEDDESKFCSYGQY
PADLAHKIHSANHMDDNDGELDTPINYSLKYSDEQLNSGRQSPSQNERWA
RPKHIIEDEIKQSEQRQSRNQSTTYPVYTESTDDKHLKFQPHFGQQECVS
PYRSRGANGSETNRVGSNHGINQNVSQSLCQEDDYEDDKPTNYSERYSEE
EQHEEEERPTNYSIKYNEEKRHVDQPIDYSLKYATDIPSSQKQSFSFSKS
SSGQSSKTEHMSSSSENTSTPSSNAKRQNQLHPSSAQSRSGQPQKAATCK
VSSINQETIQTYCVEDTPICFSRCSSLSSLSSAEDEIGCNQTTQEADSAN
TLQIAEIKEKIGTRSAEDPVSEVPAVSQHPRTKSSRLQGSSLSSESARHK
AVEFSSGAKSPSKSGAQTPKSPPEHYVQETPLMFSRCTSVSSLDSFESRS
IASSVQSEPCSGMVSGIISPSDLPDSPGQTMPPSRSKTPPPPPQTAQTKR
EVPKNKAPTAEKRESGPKQAAVNAAVQRVQVLPDADTLLHFATESTPDGF
SCSSSLSALSLDEPFIQKDVELRIMPPVQENDNGNETESEQPKESNENQE
KEAEKTIDSEKDLLDDSDDDDIEILEECIISAMPTKSSRKAKKPAQTASK
LPPPVARKPSQLPVYKLLPSQNRLQPQKHVSFTPGDDMPRVYCVEGTPIN
FSTATSLSDLTIESPPNELAAGEGVRGGAQSGEFEKRDTIPTEGRSTDEA
QGGKTSSVTIPELDDNKAEEGDILAECINSAMPKGKSHKPFRVKKIMDQV
QQASASSSAPNKNQLDGKKKKPTSPVKPIPQNTEYRTRVRKNADSKNNLN
AERVFSDNKDSKKQNLKNNSKVFNDKLPNNEDRVRGSFAFDSPHHYTPIE
GTPYCFSRNDSLSSLDFDDDDVDLSREKAELRKAKENKESEAKVTSHTEL
TSNQQSANKTQAIAKQPINRGQPKPILQKQSTFPQSSKDIPDRGAATDEK
LQNFAIENTPVCFSHNSSLSSLSDIDQENNNKENEPIKETEPPDSQGEPS
KPQASGYAPKSFHVEDTPVCFSRNSSLSSLSIDSEDDLLQECISSAMPKK
KKPSRLKGDNEKHSPRNMGGILGEDLTLDLKDIQRPDSEHGLSPDSENFD
WKAIQEGANSIVSSLHQAAAAACLSRQASSDSDSILSLKSGISLGSPFHL
TPDQEEKPFTSNKGPRILKPGEKSTLETKKIESESKGIKGGKKVYKSLIT
GKVRSNSEISGQMKQPLQANMPSISRGRTMIHIPGVRNSSSSTSPVSKKG
PPLKTPASKSPSEGQTATTSPRGAKPSVKSELSPVARQTSQIGGSSKAPS
RSGSRDSTPSRPAQQPLSRPIQSPGRNSISPGRNGISPPNKLSQLPRTSS
PSTASTKSSGSGKMSYTSPGRQMSQQNLTKQTGLSKNASSIPRSESASKG
LNQMNNGNGANKKVELSRMSSTKSSGSESDRSERPVLVRQSTFIKEAPSP
TLRRKLEESASFESLSPSSRPASPTRSQAQTPVLSPSLPDMSLSTHSSVQ
AGGWRKLPPNLSPTIEYNDGRPAKRHDIARSHSESPSRLPINRSGTWKRE
HSKHSSSLPRVSTWRRTGSSSSILSASSESSEKAKSEDEKHVNSISGTKQ
SKENQVSAKGTWRKIKENEFSPTNSTSQTVSSGATNGAESKTLIYQMAPA
VSKTEDVWVRIEDCPINNPRSGRSPTGNTPPVIDSVSEKANPNIKDSKDN
QAKQNVGNGSVPMRTVGLENRLNSFIQVDAPDQKGTEIKPGQNNPVPVSE
TNESSIVERTPFSSSSSSKHSSPSGTVAARVTPFNYNPSPRKSSADSTSA
RPSQIPTPVNNNTKKRDSKTDSTESSGTQSPKRHSGSYLVTSV

Кодований геном білок за функцією належить до фосфопротеїнів. Задіяний у таких біологічних процесах як сигнальний шлях Wnt, поліморфізм, ацетилювання, альтернативний сплайсинг. Локалізований у клітинній мембрані, цитоплазмі, цитоскелеті, мембрані, клітинних контактах, клітинних відростках.

Література ред.

  • Su L.-K., Vogelstein B., Kinzler K.W. (1993). Association of the APC tumor suppressor protein with catenins.. Science 262: 1734 — 1737.  PubMed DOI:10.1126/science.8259519
  • Bu W., Su L.-K. (2003). Characterization of functional domains of human EB1 family proteins.. J. Biol. Chem. 278: 49721 — 49731.  PubMed DOI:10.1074/jbc.M306194200
  • Choi J., Park S.Y., Costantini F., Jho E.-H., Joo C.-K. (2004). Adenomatous polyposis coli is down-regulated by the ubiquitin-proteasome pathway in a process facilitated by Axin.. J. Biol. Chem. 279: 49188 — 49198.  PubMed DOI:10.1074/jbc.M404655200
  • Tran H., Hamada F., Schwarz-Romond T., Bienz M. (2008). Trabid, a new positive regulator of Wnt-induced transcription with preference for binding and cleaving K63-linked ubiquitin chains.. Genes Dev. 22: 528 — 542.  PubMed DOI:10.1101/gad.463208
  • Zaoui K., Benseddik K., Daou P., Salaun D., Badache A. (2010). ErbB2 receptor controls microtubule capture by recruiting ACF7 to the plasma membrane of migrating cells.. Proc. Natl. Acad. Sci. U.S.A. 107: 18517 — 18522.  PubMed DOI:10.1073/pnas.1000975107
  • Pfister A.S., Tanneberger K., Schambony A., Behrens J. (2012). Amer2 protein is a novel negative regulator of Wnt/beta-Catenin signaling involved in neuroectodermal patterning.. J. Biol. Chem. 287: 1734 — 1741.  PubMed DOI:10.1074/jbc.M111.308650

Примітки ред.

  1. Захворювання, генетично пов'язані з APC переглянути/редагувати посилання на ВікіДаних. 
  2. Human PubMed Reference:. 
  3. Mouse PubMed Reference:. 
  4. HUGO Gene Nomenclature Commitee, HGNC:583 (англ.). Процитовано 31 серпня 2017. 
  5. (англ.). Архів оригіналу за 5 вересня 2017. Процитовано 31 серпня 2017. 

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Дата публікації:
APC angl APC WNT signaling pathway regulator bilok yakij koduyetsya odnojmennim genom roztashovanim u lyudej na korotkomu plechi 5 yi hromosomi 4 Dovzhina polipeptidnogo lancyuga bilka stanovit 2 843 aminokislot a molekulyarna masa 311 646 5 APCNayavni strukturiPDBPoshuk ortologiv PDBe RCSBSpisok kodiv PDB1DEB 1EMU 1JPP 1M5I 1T08 1TH1 1V18 2RQU 3AU3 3NMW 3NMX 3NMZ 3QHE 3RL7 3RL8 3T7U 4G69 4YJL 4YK6 4YJEIdentifikatoriSimvoliAPC BTPS2 DP2 DP2 5 DP3 GS PPP1R46 adenomatous polyposis coli WNT signaling pathway regulator GenesZovnishni ID OMIM 611731 MGI 88039 HomoloGene 30950 GeneCards APCPov yazani genetichni zahvoryuvannyaAPC related attenuated familial adenomatous polyposis liver carcinoma large intestine adenocarcinoma large intestine cancer desmoid disease hereditary sindrom Gardnera familial adenomatous polyposis 1 Ontologiya genaMolekulyarna funkciya gamma catenin binding protein kinase binding microtubule plus end binding microtubule binding cadherin binding protein kinase regulator activity GO 0001948 GO 0016582 protein binding beta catenin binding ubiquitin protein ligase binding identical protein binding dynein complex bindingKlitinna komponenta Citoskelet Adgezivni kontakti beta catenin destruction complex Nukleoplazma citoplazma cell projection gialoplazma catenin complex Mizhklitinni kontakti klitinne yadro lamellipodium membrana Wnt signalosome centrosoma Kinetohor bicellular tight junction ruffle membrane klitinna membrana lateral plasma membrane perinuclear region of cytoplasm Mikrotrubochki cytoplasmic microtubuleBiologichnij proces negative regulation of cell population proliferation negative regulation of cyclin dependent protein serine threonine kinase activity mitotic spindle assembly checkpoint signaling positive regulation of cell migration GO 1903364 positive regulation of protein catabolic process bicellular tight junction assembly regulation of microtubule based process positive regulation of pseudopodium assembly regulation of attachment of spindle microtubules to kinetochore cellular response to DNA damage stimulus negative regulation of Wnt signaling pathway adgeziya klitin mitotic cytokinesis negative regulation of microtubule depolymerization positive regulation of apoptotic process canonical Wnt signaling pathway cell migration beta catenin destruction complex assembly beta catenin destruction complex disassembly negative regulation of canonical Wnt signaling pathway Wnt signaling pathway protein deubiquitination GO 1901047 insulin receptor signaling pathway positive regulation of cell death protein homooligomerization positive regulation of protein localization to centrosome GO 0034622 protein containing complex assembly cell fate specification pattern specification process regulation of cell differentiation positive regulation of cold induced thermogenesisDzherela Amigo QuickGOShablon ekspresiyiBilshe danihOrtologiVidi Lyudina MishaEntrez324 11789Ensembl ENSG00000134982 ENSMUSG00000005871UniProt P25054 Q61315RefSeq mRNK NM 001127511NM 000038NM 001127510NM 007462NM 001360979NM 001360980RefSeq bilok NP 000029NP 001120982NP 001120983NP 001341824NP 001341825NP 001341826NP 001341827NP 001341828NP 001341829NP 001341830NP 001341831NP 001341832NP 001341833NP 001341834NP 001341835n dLokus UCSC n dHr 18 34 22 34 32 MbPubMed search 2 3 VikidaniDiv Red dlya lyudejDiv Red dlya mishej Poslidovnist aminokislot1020304050MAAASYDQLLKQVEALKMENSNLRQELEDNSNHLTKLETEASNMKEVLKQLQGSIEDEAMASSGQIDLLERLKELNLDSSNFPGVKLRSKMSLRSYGSREGSVSSRSGECSPVPMGSFPRRGFVNGSRESTGYLEELEKERSLLLADLDKEEKEKDWYYAQLQNLTKRIDSLPLTENFSLQTDMTRRQLEYEARQIRVAMEEQLGTCQDMEKRAQRRIARIQQIEKDILRIRQLLQSQATEAERSSQNKHETGSHDAERQNEGQGVGEINMATSGNGQGSTTRMDHETASVLSSSSTHSAPRRLTSHLGTKVEMVYSLLSMLGTHDKDDMSRTLLAMSSSQDSCISMRQSGCLPLLIQLLHGNDKDSVLLGNSRGSKEARARASAALHNIIHSQPDDKRGRREIRVLHLLEQIRAYCETCWEWQEAHEPGMDQDKNPMPAPVEHQICPAVCVLMKLSFDEEHRHAMNELGGLQAIAELLQVDCEMYGLTNDHYSITLRRYAGMALTNLTFGDVANKATLCSMKGCMRALVAQLKSESEDLQQVIASVLRNLSWRADVNSKKTLREVGSVKALMECALEVKKESTLKSVLSALWNLSAHCTENKADICAVDGALAFLVGTLTYRSQTNTLAIIESGGGILRNVSSLIATNEDHRQILRENNCLQTLLQHLKSHSLTIVSNACGTLWNLSARNPKDQEALWDMGAVSMLKNLIHSKHKMIAMGSAAALRNLMANRPAKYKDANIMSPGSSLPSLHVRKQKALEAELDAQHLSETFDNIDNLSPKASHRSKQRHKQSLYGDYVFDTNRHDDNRSDNFNTGNMTVLSPYLNTTVLPSSSSSRGSLDSSRSEKDRSLERERGIGLGNYHPATENPGTSSKRGLQISTTAAQIAKVMEEVSAIHTSQEDRSSGSTTELHCVTDERNALRRSSAAHTHSNTYNFTKSENSNRTCSMPYAKLEYKRSSNDSLNSVSSSDGYGKRGQMKPSIESYSEDDESKFCSYGQYPADLAHKIHSANHMDDNDGELDTPINYSLKYSDEQLNSGRQSPSQNERWARPKHIIEDEIKQSEQRQSRNQSTTYPVYTESTDDKHLKFQPHFGQQECVSPYRSRGANGSETNRVGSNHGINQNVSQSLCQEDDYEDDKPTNYSERYSEEEQHEEEERPTNYSIKYNEEKRHVDQPIDYSLKYATDIPSSQKQSFSFSKSSSGQSSKTEHMSSSSENTSTPSSNAKRQNQLHPSSAQSRSGQPQKAATCKVSSINQETIQTYCVEDTPICFSRCSSLSSLSSAEDEIGCNQTTQEADSANTLQIAEIKEKIGTRSAEDPVSEVPAVSQHPRTKSSRLQGSSLSSESARHKAVEFSSGAKSPSKSGAQTPKSPPEHYVQETPLMFSRCTSVSSLDSFESRSIASSVQSEPCSGMVSGIISPSDLPDSPGQTMPPSRSKTPPPPPQTAQTKREVPKNKAPTAEKRESGPKQAAVNAAVQRVQVLPDADTLLHFATESTPDGFSCSSSLSALSLDEPFIQKDVELRIMPPVQENDNGNETESEQPKESNENQEKEAEKTIDSEKDLLDDSDDDDIEILEECIISAMPTKSSRKAKKPAQTASKLPPPVARKPSQLPVYKLLPSQNRLQPQKHVSFTPGDDMPRVYCVEGTPINFSTATSLSDLTIESPPNELAAGEGVRGGAQSGEFEKRDTIPTEGRSTDEAQGGKTSSVTIPELDDNKAEEGDILAECINSAMPKGKSHKPFRVKKIMDQVQQASASSSAPNKNQLDGKKKKPTSPVKPIPQNTEYRTRVRKNADSKNNLNAERVFSDNKDSKKQNLKNNSKVFNDKLPNNEDRVRGSFAFDSPHHYTPIEGTPYCFSRNDSLSSLDFDDDDVDLSREKAELRKAKENKESEAKVTSHTELTSNQQSANKTQAIAKQPINRGQPKPILQKQSTFPQSSKDIPDRGAATDEKLQNFAIENTPVCFSHNSSLSSLSDIDQENNNKENEPIKETEPPDSQGEPSKPQASGYAPKSFHVEDTPVCFSRNSSLSSLSIDSEDDLLQECISSAMPKKKKPSRLKGDNEKHSPRNMGGILGEDLTLDLKDIQRPDSEHGLSPDSENFDWKAIQEGANSIVSSLHQAAAAACLSRQASSDSDSILSLKSGISLGSPFHLTPDQEEKPFTSNKGPRILKPGEKSTLETKKIESESKGIKGGKKVYKSLITGKVRSNSEISGQMKQPLQANMPSISRGRTMIHIPGVRNSSSSTSPVSKKGPPLKTPASKSPSEGQTATTSPRGAKPSVKSELSPVARQTSQIGGSSKAPSRSGSRDSTPSRPAQQPLSRPIQSPGRNSISPGRNGISPPNKLSQLPRTSSPSTASTKSSGSGKMSYTSPGRQMSQQNLTKQTGLSKNASSIPRSESASKGLNQMNNGNGANKKVELSRMSSTKSSGSESDRSERPVLVRQSTFIKEAPSPTLRRKLEESASFESLSPSSRPASPTRSQAQTPVLSPSLPDMSLSTHSSVQAGGWRKLPPNLSPTIEYNDGRPAKRHDIARSHSESPSRLPINRSGTWKREHSKHSSSLPRVSTWRRTGSSSSILSASSESSEKAKSEDEKHVNSISGTKQSKENQVSAKGTWRKIKENEFSPTNSTSQTVSSGATNGAESKTLIYQMAPAVSKTEDVWVRIEDCPINNPRSGRSPTGNTPPVIDSVSEKANPNIKDSKDNQAKQNVGNGSVPMRTVGLENRLNSFIQVDAPDQKGTEIKPGQNNPVPVSETNESSIVERTPFSSSSSSKHSSPSGTVAARVTPFNYNPSPRKSSADSTSARPSQIPTPVNNNTKKRDSKTDSTESSGTQSPKRHSGSYLVTSVA Alanin C Cisteyin D Asparaginova kislota E Glutaminova kislota F Fenilalanin G Glicin H Gistidin I Izolejcin K Lizin L Lejcin M Metionin N Asparagin P Prolin Q Glutamin R Arginin S Serin T Treonin V Valin W Triptofan Y Tirozin Kodovanij genom bilok za funkciyeyu nalezhit do fosfoproteyiniv Zadiyanij u takih biologichnih procesah yak signalnij shlyah Wnt polimorfizm acetilyuvannya alternativnij splajsing Lokalizovanij u klitinnij membrani citoplazmi citoskeleti membrani klitinnih kontaktah klitinnih vidrostkah Literatura red Su L K Vogelstein B Kinzler K W 1993 Association of the APC tumor suppressor protein with catenins Science 262 1734 1737 PubMed DOI 10 1126 science 8259519 Bu W Su L K 2003 Characterization of functional domains of human EB1 family proteins J Biol Chem 278 49721 49731 PubMed DOI 10 1074 jbc M306194200 Choi J Park S Y Costantini F Jho E H Joo C K 2004 Adenomatous polyposis coli is down regulated by the ubiquitin proteasome pathway in a process facilitated by Axin J Biol Chem 279 49188 49198 PubMed DOI 10 1074 jbc M404655200 Tran H Hamada F Schwarz Romond T Bienz M 2008 Trabid a new positive regulator of Wnt induced transcription with preference for binding and cleaving K63 linked ubiquitin chains Genes Dev 22 528 542 PubMed DOI 10 1101 gad 463208 Zaoui K Benseddik K Daou P Salaun D Badache A 2010 ErbB2 receptor controls microtubule capture by recruiting ACF7 to the plasma membrane of migrating cells Proc Natl Acad Sci U S A 107 18517 18522 PubMed DOI 10 1073 pnas 1000975107 Pfister A S Tanneberger K Schambony A Behrens J 2012 Amer2 protein is a novel negative regulator of Wnt beta Catenin signaling involved in neuroectodermal patterning J Biol Chem 287 1734 1741 PubMed DOI 10 1074 jbc M111 308650Primitki red Zahvoryuvannya genetichno pov yazani z APC pereglyanuti redaguvati posilannya na VikiDanih Human PubMed Reference Mouse PubMed Reference HUGO Gene Nomenclature Commitee HGNC 583 angl Procitovano 31 serpnya 2017 UniProt P25054 angl Arhiv originalu za 5 veresnya 2017 Procitovano 31 serpnya 2017 Div takozh red Hromosoma 5 nbsp Ce nezavershena stattya pro bilki Vi mozhete dopomogti proyektu vipravivshi abo dopisavshi yiyi Otrimano z https uk wikipedia org w index php title APC gen amp oldid 35337171