TRPV1 angl Transient receptor potential cation channel subfamily V member 1 bilok yakij koduyetsya odnojmennim genom TRPV1 roztashovanim u lyudej na korotkomu plechi 17 yi hromosomi 4 Dovzhina polipeptidnogo lancyuga bilka stanovit 839 aminokislot a molekulyarna masa 94 956 Da 5 TRPV1IdentifikatoriSimvoliTRPV1 VR1 transient receptor potential cation channel subfamily V member 1Zovnishni ID OMIM 602076 MGI 1341787 HomoloGene 12920 GeneCards TRPV1Reaguye na spolukuAnandamid kapsayicin piperine 5S HETE Kamfora gidron capsazepine 2 aminoethoxydiphenylborate 5 iodoresiniferatoxin Alicin NADA amg 517 AZD1386 SB 705498 1 Ontologiya genaMolekulyarna funkciya nucleotide binding ion channel activity phosphoprotein binding ATP binding cation transmembrane transporter activity cation channel activity ligand gated ion channel activity calcium release channel activity temperature gated ion channel activity identical protein binding chloride channel regulator activity transmembrane signaling receptor activity excitatory extracellular ligand gated ion channel activity calcium channel activity extracellular ligand gated ion channel activity phosphatidylinositol binding zv yazuvannya z ionom metalu calmodulin binding GO 0001948 GO 0016582 protein bindingKlitinna komponenta integral component of membrane postsynaptic membrane cell projection membrana klitinna membrana sinaps Mizhklitinni kontakti dendritic spine membrane gialoplazma neuronal cell body intrinsic component of plasma membrane Dendrit nejrobiologiya external side of plasma membrane neuron projection integral component of plasma membrane mitohondriyaBiologichnij proces ion transport chemosensory behavior cell surface receptor signaling pathway calcium ion transmembrane transport thermoception calcium ion transport inflammatory response transmembrannij transport release of sequestered calcium ion into cytosol GO 1901227 negative regulation of transcription by RNA polymerase II diet induced thermogenesis detection of chemical stimulus involved in sensory perception of pain microglial cell activation cellular response to growth factor stimulus positive regulation of gastric acid secretion response to peptide hormone cellular response to nerve growth factor stimulus positive regulation of nitric oxide biosynthetic process negative regulation of establishment of blood brain barrier lipid metabolism temperature homeostasis response to heat cellular response to temperature stimulus positive regulation of cytosolic calcium ion concentration peptide secretion detection of temperature stimulus involved in sensory perception of pain sensory perception of mechanical stimulus smooth muscle contraction involved in micturition behavioral response to pain response to pain cellular response to alkaloid cellular response to cytokine stimulus fever generation detection of temperature stimulus involved in thermoception positive regulation of apoptotic process urinary bladder smooth muscle contraction glutamate secretion sensory perception of pain cellular response to tumor necrosis factor cellular response to ATP ion transmembrane transport response to pH response to organonitrogen compound cellular response to heat protein homotetramerization excitatory postsynaptic potential cellular response to acidic pH response to capsazepine calcium ion import across plasma membrane negative regulation of systemic arterial blood pressure negative regulation of heart rate negative regulation of mitochondrial membrane potentialDzherela Amigo QuickGOShablon ekspresiyiBilshe danihOrtologiVidi Lyudina MishaEntrez7442 193034Ensembl ENSG00000196689 ENSMUSG00000005952UniProt Q8NER1 Q704Y3RefSeq mRNK NM 018727NM 080704NM 080705NM 080706NM 001001445RefSeq bilok NP 061197NP 542435NP 542436NP 542437NP 001001445Lokus UCSC Hr 17 3 57 3 61 MbHr 11 73 13 73 15 MbPubMed search 2 3 VikidaniDiv Red dlya lyudejDiv Red dlya mishej Poslidovnist aminokislot1020304050MKKWSSTDLGAAADPLQKDTCPDPLDGDPNSRPPPAKPQLSTAKSRTRLFGKGDSEEAFPVDCPHEEGELDSCPTITVSPVITIQRPGDGPTGARLLSQDSVAASTEKTLRLYDRRSIFEAVAQNNCQDLESLLLFLQKSKKHLTDNEFKDPETGKTCLLKAMLNLHDGQNTTIPLLLEIARQTDSLKELVNASYTDSYYKGQTALHIAIERRNMALVTLLVENGADVQAAAHGDFFKKTKGRPGFYFGELPLSLAACTNQLGIVKFLLQNSWQTADISARDSVGNTVLHALVEVADNTADNTKFVTSMYNEILMLGAKLHPTLKLEELTNKKGMTPLALAAGTGKIGVLAYILQREIQEPECRHLSRKFTEWAYGPVHSSLYDLSCIDTCEKNSVLEVIAYSSSETPNRHDMLLVEPLNRLLQDKWDRFVKRIFYFNFLVYCLYMIIFTMAAYYRPVDGLPPFKMEKTGDYFRVTGEILSVLGGVYFFFRGIQYFLQRRPSMKTLFVDSYSEMLFFLQSLFMLATVVLYFSHLKEYVASMVFSLALGWTNMLYYTRGFQQMGIYAVMIEKMILRDLCRFMFVYIVFLFGFSTAVVTLIEDGKNDSLPSESTSHRWRGPACRPPDSSYNSLYSTCLELFKFTIGMGDLEFTENYDFKAVFIILLLAYVILTYILLLNMLIALMGETVNKIAQESKNIWKLQRAITILDTEKSFLKCMRKAFRSGKLLQVGYTPDGKDDYRWCFRVDEVNWTTWNTNVGIINEDPGNCEGVKRTLSFSLRSSRVSGRHWKNFALVPLLREASARDRQSAQPEEVYLRQFSGSLKPEDAEVFKSPAASGEKA Alanin C Cisteyin D Asparaginova kislota E Glutaminova kislota F Fenilalanin G Glicin H Gistidin I Izolejcin K Lizin L Lejcin M Metionin N Asparagin P Prolin Q Glutamin R Arginin S Serin T Treonin V Valin W Triptofan Y TirozinTRPV1 ce neselektivnij kationnij kanal ta nalezhit do ionnih kanaliv yakij aktivuyetsya protonami vaniloyidnimi spolukami kapsayicinom CAP reziniferatoksinom RTX lipidami sho nadhodyat z membran vklyuchayuchi anandamid Caterina et al 1997 Arhivovano 3 grudnya 2020 u Wayback Machine Caterina and Julius 2001 Arhivovano 20 sichnya 2021 u Wayback Machine Kapsayicin ye najbilsh potuzhnim i specifichnim vidomim agonistom TRPV1 Zmist 1 Funkciyi bilka TRPV1 2 Ekspresiya gena TRPV1 3 Rozladi sho pov yazani z TRPV1 4 Primitki 5 Div takozhFunkciyi bilka TRPV1 red TRPV1 zadiyanij u takih biologichnih procesah yak transport ioniv transport transport kalciyu Bilok maye sajt dlya zv yazuvannya z ATF nukleotidami molekuloyu kalmodulinu ionami metaliv ionom kalciyu Cej receptor takozh aktivuyetsya pidvishennyam temperaturi v shkidlivomu diapazoni tozh mozhlivo sho vin funkcionuye yak peretvoryuvach bolyuchih teplovih podraznikiv in vivo 6 Lokalizovanij u klitinnij membrani membrani klitinnih kontaktah klitinnih vidrostkah sinapsah Ekspresiya gena TRPV1 red Cej gen maye 10 transkriptiv splajs variantiv 197 ortologiv ta 5 paralogiv 7 Ekspresiya TRPV1 v CNS maye vazhlive znachennya dlya potencijnih pobichnih efektiv agonistiv i antagonistiv TRPV1 sho rozroblyayutsya dlya likuvannya hronichnogo bolyu 8 Cavanaugh et al 2011 Arhivovano 19 sichnya 2019 u Wayback Machine doslidzhuvali ekspresiyu TRPV1 vikoristovuyuchi metod gennogo nacilyuvannya dlya modifikaciyi genetichnogo lokusu TRPV1 Bula prodemonstrovana stijka ekspresiya TRPV1 u pervinnih aferentnih nejronah ta viyavlena u pidmnozhini klitin gladkih m yaziv v tkaninah sho vikonuyut funkciyu termoregulyaciyi Rozladi sho pov yazani z TRPV1 red Somatoformnij rozladSomatoformnij rozlad pov yazanij iz trivogoyu ta obsesivno kompulsivnim rozladom i maye taki simptomi yak sudomi zadishka ta zapamorochennya Vazhlivim genom asocijovanim iz somatoformnim rozladom ye TRPV1 9 Sindrom palayuchogo rota en Sindrom pechinnya rota takozh vidomij yak stomatodiniya pov yazanij z glositom ta hvoroboyu Graft versus host disease en i maye simptomi vklyuchayuchi peroralni proyavi Vazhlivim genom pov yazanim iz sindromom ye TRPV1 10 Primitki red Spoluki yaki fizichno vzayemodiyut z TRPV1 pereglyanuti redaguvati posilannya na VikiDanih Human PubMed Reference Mouse PubMed Reference HUGO Gene Nomenclature Commitee HGNC 12716 angl Procitovano 22 serpnya 2017 UniProt Q8NER1 angl Arhiv originalu za 25 serpnya 2017 Procitovano 22 serpnya 2017 TRPV1 Gene GeneCards TRPV1 Protein TRPV1 Antibody www genecards org Arhiv originalu za 25 sichnya 2021 Procitovano 23 grudnya 2020 Gene TRPV1 ENSG00000196689 Summary Homo sapiens Ensembl genome browser 102 www ensembl org Arhiv originalu za 9 chervnya 2019 Procitovano 23 grudnya 2020 Cavanaugh Daniel J Chesler Alexander T Jackson Alexander C Sigal Yaron M Yamanaka Hiroki Grant Rebecca O Donnell Dajan Nicoll Roger A ta in 30 bereznya 2011 Trpv1 Reporter Mice Reveal Highly Restricted Brain Distribution and Functional Expression in Arteriolar Smooth Muscle Cells Journal of Neuroscience angl 31 13 s 5067 5077 ISSN 0270 6474 PMID 21451044 doi 10 1523 JNEUROSCI 6451 10 2011 Arhiv originalu za 21 chervnya 2021 Procitovano 23 grudnya 2020 rekomenduyetsya displayauthors dovidka Somatoform Disorder disease Malacards Research Articles Drugs Genes Clinical Trials www malacards org Arhiv originalu za 14 chervnya 2021 Procitovano 23 grudnya 2020 Burning Mouth Syndrome disease Malacards Research Articles Drugs Genes Clinical Trials www malacards org Arhiv originalu za 11 travnya 2021 Procitovano 23 grudnya 2020 Div takozh red Hromosoma 17 nbsp Ce nezavershena stattya pro bilki Vi mozhete dopomogti proyektu vipravivshi abo dopisavshi yiyi Otrimano z https uk wikipedia org w index php title TRPV1 amp oldid 39767224
