Angiogenin angl Angiogenin bilok yakij koduyetsya genom ANG roztashovanim u lyudini na dovgomu plechi 14 yi hromosomi 4 Dovzhina polipeptidnogo lancyuga bilka stanovit 147 aminokislot a molekulyarna masa 16 550 5 Angiogenin zaluchenij v proces angiogenezu utvorennya novih krovonosnih sudin puhlin Sered bagatoh peptidiv zaluchenij v cej proces angiogenin unikalnij tim sho vin maye fermentativnu aktivnist ta maye 33 aminokislotnoyi poslidovnosti gomologichnoyi poslidovnisti bichachoyi pankreatichnij ribonukleazi Okrim togo hocha Ang maye ti zh zagalni katalitichni vlastivosti sho j ribonukleaza vin rujnuye zv yazok v 3 poziciyi pirimidiniv za dopomogoyu mehanizmu transforforilyuvannya gidrolizu jogo aktivnist pomitno vidriznyayetsya yak velichinoyu tak i v specifichnistyu AngiogeninNayavni strukturiPDBPoshuk ortologiv PDBe RCSBSpisok kodiv PDB1A4Y 1ANG 1AWZ 1B1E 1B1I 1B1J 1GV7 1H0D 1H52 1H53 1HBY 1K58 1K59 1K5A 1K5B 1UN3 1UN4 1UN5 2ANG 4AHD 4AHE 4AHF 4AHG 4AHH 4AHI 4AHJ 4AHK 4AHL 4AHM 4AHN 4AOH 4B36IdentifikatoriSimvoliANG ALS9 HEL168 RAA1 RNASE4 RNASE5 angiogenin ribonuclease RNase A family 5 angiogeninZovnishni ID OMIM 105850 MGI 88022 HomoloGene 74385 GeneCards ANGPov yazani genetichni zahvoryuvannyaamyotrophic lateral sclerosis type 9 1 Ontologiya genaMolekulyarna funkciya DNA binding rRNA binding heparin binding protein homodimerization activity peptidnij zv yazok GO 0001948 GO 0016582 protein binding nucleic acid binding nuclease activity endonuclease activity actin binding copper ion binding signaling receptor binding hydrolase activity ribonuclease activityKlitinna komponenta extracellular region Yaderce angiogenin PRI complex GO 0016023 cytoplasmic vesicle klitinne yadro extracellular space growth cone neuronal cell body Bazalna membranaBiologichnij proces Diferenciaciya klitin negative regulation of smooth muscle cell proliferation negative regulation of translation activation of protein kinase B activity response to hypoxia positive regulation of endothelial cell proliferation placenta development rRNA transcription activation of phospholipase C activity GO 0043006 activation of phospholipase A2 activity diacylglycerol biosynthetic process multicellular organism development cell communication actin filament polymerization oocyte maturation Angiogenez positive regulation of protein secretion ovarian follicle development response to hormone positive regulation of phosphorylation adherens junction organization cell migration homeostatic process nucleic acid phosphodiester bond hydrolysis RNA phosphodiester bond hydrolysis Vrodzhenij imunitet antimicrobial humoral immune response mediated by antimicrobial peptideDzherela Amigo QuickGOOrtologiVidi Lyudina MishaEntrez283 11727Ensembl ENSG00000214274 ENSMUSG00000072115UniProt P03950 P21570RefSeq mRNK NM 001145NM 001097577NM 001161731NM 007447RefSeq bilok NP 001091046NP 001136NP 001155203NP 031473Lokus UCSC Hr 14 20 68 20 7 MbHr 14 51 33 51 34 MbPubMed search 2 3 VikidaniDiv Red dlya lyudejDiv Red dlya mishejKompleks ingibitora ribonukleazi i angiogenina PDB 1a4y Poslidovnist aminokislot1020304050MVMGLGVLLLVFVLGLGLTPPTLAQDNSRYTHFLTQHYDAKPQGRDDRYCESIMRRRGLTSPCKDINTFIHGNKRSIKAICENKNGNPHRENLRISKSSFQVTTCKLHGGSPWPPCQYRATAGFRNVVVACENGLPVHLDQSIFRRPA Alanin C Cisteyin D Asparaginova kislota E Glutaminova kislota F Fenilalanin G Glicin H Gistidin I Izolejcin K Lizin L Lejcin M Metionin N Asparagin P Prolin Q Glutamin R Arginin S Serin T Treonin V Valin W Triptofan Y Tirozin Cej bilok za funkciyami nalezhit do bilkiv rozvitku endonukleaz ingibitoriv sintezu bilka Zadiyanij u takih biologichnih procesah yak vidpovid na stres angiogenez diferenciaciya klitin Bilok maye sajt dlya zv yazuvannya z DNK Lokalizovanij u yadri citoplazmatichnih vezikulah Takozh sekretovanij nazovni Literatura red Kurachi K Davie E W Strydom D J Riordan J F Vallee B L 1985 Sequence of the cDNA and gene for angiogenin a human angiogenesis factor Biochemistry 24 5494 5499 PubMed DOI 10 1021 bi00341a032 Zhang J Rosenberg H F 2002 Diversifying selection of the tumor growth promoter angiogenin in primate evolution Mol Biol Evol 19 438 445 PubMed DOI 10 1093 oxfordjournals molbev a004099 The status quality and expansion of the NIH full length cDNA project the Mammalian Gene Collection MGC Genome Res 14 2121 2127 2004 PubMed DOI 10 1101 gr 2596504 Weiner H L Weiner L H Swain J L 1987 Tissue distribution and developmental expression of the messenger RNA encoding angiogenin Science 237 280 282 PubMed DOI 10 1126 science 2440105 Moroianu J Riordan J F 1994 Identification of the nucleolar targeting signal of human angiogenin Biochem Biophys Res Commun 203 1765 1772 PubMed DOI 10 1006 bbrc 1994 2391 Chen C Z Shapiro R 1997 Site specific mutagenesis reveals differences in the structural bases for tight binding of RNase inhibitor to angiogenin and RNase A Proc Natl Acad Sci U S A 94 1761 1766 PubMed DOI 10 1073 pnas 94 5 1761Primitki red Zahvoryuvannya genetichno pov yazani z Angiogenin pereglyanuti redaguvati posilannya na VikiDanih Human PubMed Reference Mouse PubMed Reference HUGO Gene Nomenclature Commitee HGNC 483 angl Arhiv originalu za 13 zhovtnya 2018 Procitovano 5 zhovtnya 2018 UniProt P03950 angl Arhiv originalu za 13 zhovtnya 2018 Procitovano 5 zhovtnya 2018 Div takozh red Hromosoma 14 nbsp Ce nezavershena stattya pro bilki Vi mozhete dopomogti proyektu vipravivshi abo dopisavshi yiyi Otrimano z https uk wikipedia org w index php title Angiogenin amp oldid 35880885
