RTN4R angl Reticulon 4 receptor bilok yakij koduyetsya odnojmennim genom roztashovanim u lyudej na korotkomu plechi 22 yi hromosomi 4 Dovzhina polipeptidnogo lancyuga bilka stanovit 473 aminokislot a molekulyarna masa 50 708 5 RTN4RNayavni strukturiPDBPoshuk ortologiv PDBe RCSBSpisok kodiv PDB1OZN 1P8TIdentifikatoriSimvoliRTN4R NGR NOGOR Reticulon 4 receptorZovnishni ID OMIM 605566 MGI 2136886 HomoloGene 11299 GeneCards RTN4RPov yazani genetichni zahvoryuvannyaozhirinnya 1 Ontologiya genaMolekulyarna funkciya neuregulin receptor activity protein kinase inhibitor activity GO 0001948 GO 0016582 protein binding heparin binding chondroitin sulfate binding ganglioside GM1 binding ganglioside GT1b binding lipid binding signaling receptor activity GO 0032403 protein containing complex bindingKlitinna komponenta citoplazma membrana growth cone klitinna membrana axonal growth cone integral component of plasma membrane neuronal cell body endoplazmatichnij retikulum anchored component of membrane neuron projection ekzosoma cell surface anchored component of external side of plasma membrane dendritic shaft membrane raft Akson Dendrit nejrobiologiya cell projection Perikarion presynapse glutamatergic synapseBiologichnij proces negative regulation of protein kinase activity cytokine mediated signaling pathway neuronal signal transduction GO 0032320 GO 0032321 GO 0032855 GO 0043089 GO 0032854 positive regulation of GTPase activity negative regulation of axonogenesis negative regulation of axon extension negative regulation of receptor signaling pathway via JAK STAT negative regulation of neuron projection development negative regulation of axon regeneration cell surface receptor signaling pathway axonogenesis corpus callosum development positive regulation of Rho protein signal transductionDzherela Amigo QuickGOOrtologiVidi Lyudina MishaEntrez65078 65079Ensembl ENSG00000040608 ENSMUSG00000043811UniProt Q9BZR6 Q99PI8RefSeq mRNK NM 023004NM 022982RefSeq bilok NP 075380NP 075358Lokus UCSC Hr 22 20 24 20 28 MbHr 16 17 95 17 97 MbPubMed search 2 3 VikidaniDiv Red dlya lyudejDiv Red dlya mishej Poslidovnist aminokislot1020304050MKRASAGGSRLLAWVLWLQAWQVAAPCPGACVCYNEPKVTTSCPQQGLQAVPVGIPAASQRIFLHGNRISHVPAASFRACRNLTILWLHSNVLARIDAAAFTGLALLEQLDLSDNAQLRSVDPATFHGLGRLHTLHLDRCGLQELGPGLFRGLAALQYLYLQDNALQALPDDTFRDLGNLTHLFLHGNRISSVPERAFRGLHSLDRLLLHQNRVAHVHPHAFRDLGRLMTLYLFANNLSALPTEALAPLRALQYLRLNDNPWVCDCRARPLWAWLQKFRGSSSEVPCSLPQRLAGRDLKRLAANDLQGCAVATGPYHPIWTGRATDEEPLGLPKCCQPDAADKASVLEPGRPASAGNALKGRVPPGDSPPGNGSGPRHINDSPFGTLPGSAEPPLTAVRPEGSEPPGFPTSGPRRRPGCSRKNRTRSHCRLGQAGSGGGGTGDSEGSGALPSLTCSLTPLGLALVLWTVLGPCA Alanin C Cisteyin D Asparaginova kislota E Glutaminova kislota F Fenilalanin G Glicin H Gistidin I Izolejcin K Lizin L Lejcin M Metionin N Asparagin P Prolin Q Glutamin R Arginin S Serin T Treonin V Valin W Triptofan Y Tirozin Kodovanij genom bilok za funkciyeyu nalezhit do receptoriv Bilok maye sajt dlya zv yazuvannya z lipidami Lokalizovanij u klitinnij membrani membrani klitinnih vidrostkah Literatura RedaguvatiFournier A E GrandPre T Strittmatter S M 2001 Identification of a receptor mediating Nogo 66 inhibition of axonal regeneration Nature 409 341 346 PubMed DOI 10 1038 35053072 The status quality and expansion of the NIH full length cDNA project the Mammalian Gene Collection MGC Genome Res 14 2121 2127 2004 PubMed DOI 10 1101 gr 2596504 Zhang Z Henzel W J 2004 Signal peptide prediction based on analysis of experimentally verified cleavage sites Protein Sci 13 2819 2824 PubMed DOI 10 1110 ps 04682504 GrandPre T Li S Strittmatter S M 2002 Nogo 66 receptor antagonist peptide promotes axonal regeneration Nature 417 547 551 PubMed DOI 10 1038 417547a Liu B P Fournier A GrandPre T Strittmatter S M 2002 Myelin associated glycoprotein as a functional ligand for the Nogo 66 receptor Science 297 1190 1193 PubMed DOI 10 1126 science 1073031 Woolf C J Bloechlinger S 2002 It takes more than two to Nogo Science 297 1132 1134 PubMed DOI 10 1126 science 1076247Primitki Redaguvati Zahvoryuvannya genetichno pov yazani z RTN4R pereglyanuti redaguvati posilannya na VikiDanih Human PubMed Reference Mouse PubMed Reference HUGO Gene Nomenclature Commitee HGNC 18601 angl Arhiv originalu za 22 bereznya 2016 Procitovano 12 veresnya 2017 UniProt Q9BZR6 angl Arhiv originalu za 8 serpnya 2017 Procitovano 12 veresnya 2017 Div takozh RedaguvatiHromosoma 22 nbsp Ce nezavershena stattya pro bilki Vi mozhete dopomogti proyektu vipravivshi abo dopisavshi yiyi Otrimano z https uk wikipedia org w index php title RTN4R amp oldid 35715244
