Bagatij na gistidin glikoproteyin angl Histidine rich glycoprotein bilok yakij koduyetsya genom HRG roztashovanim u lyudej na korotkomu plechi 3 yi hromosomi 3 Dovzhina polipeptidnogo lancyuga bilka stanovit 525 aminokislot a molekulyarna masa 59 578 4 Bagatij na gistidin glikoproteyinIdentifikatoriSimvoliHRG HPRG HRGP THPH11 histidine rich glycoproteinZovnishni ID OMIM 142640 HomoloGene 133557 GeneCards HRGPov yazani genetichni zahvoryuvannyahereditary thrombophilia due to congenital histidine rich poly L glycoprotein deficiency 1 Ontologiya genaMolekulyarna funkciya heparin binding cysteine type endopeptidase inhibitor activity zinc ion binding immunoglobulin binding zv yazuvannya z ionom metalu GO 0001948 GO 0016582 protein binding heme binding serine type endopeptidase inhibitor activity heparan sulfate proteoglycan binding signaling receptor bindingKlitinna komponenta endolysosome blood microparticle klitinna membrana extracellular region ekzosoma platelet alpha granule lumen cell surface collagen containing extracellular matrixBiologichnij proces gemostaz negative regulation of cell adhesion negative regulation of fibrinolysis regulation of actin cytoskeleton organization negative regulation of blood vessel endothelial cell migration positive regulation of immune response to tumor cell Fibrinoliz platelet degranulation heme transport negative regulation of endothelial cell chemotaxis hemotaksis positive regulation of blood vessel remodeling negative regulation of cell growth Angiogenez positive regulation of apoptotic process Regulyaciya ekspresiyi geniv negative regulation of angiogenesis positive regulation of focal adhesion assembly negative regulation of vascular endothelial growth factor signaling pathway regulation of platelet activation regulation of blood coagulation GO 0106159 regulation of protein containing complex assembly negative regulation of cell adhesion mediated by integrin negative regulation of cell population proliferation negative regulation of lamellipodium assembly regulation of peptidyl tyrosine phosphorylation zsidannya krovi platelet activation negative regulation of endopeptidase activity antimicrobial humoral immune response mediated by antimicrobial peptideDzherela Amigo QuickGOShablon ekspresiyiBilshe danihOrtologiVidi Lyudina MishaEntrez3273 n dEnsembl ENSG00000113905 n dUniProt P04196 n dRefSeq mRNK NM 000412n dRefSeq bilok NP 000403n dLokus UCSC Hr 3 186 66 186 68 Mbn dPubMed search 2 n dVikidaniDiv Red dlya lyudej Poslidovnist aminokislot1020304050MKALIAALLLITLQYSCAVSPTDCSAVEPEAEKALDLINKRRRDGYLFQLLRIADAHLDRVENTTVYYLVLDVQESDCSVLSRKYWNDCEPPDSRRPSEIVIGQCKVIATRHSHESQDLRVIDFNCTTSSVSSALANTKDSPVLIDFFEDTERYRKQANKALEKYKEENDDFASFRVDRIERVARVRGGEGTGYFVDFSVRNCPRHHFPRHPNVFGFCRADLFYDVEALDLESPKNLVINCEVFDPQEHENINGVPPHLGHPFHWGGHERSSTTKPPFKPHGSRDHHHPHKPHEHGPPPPPDERDHSHGPPLPQGPPPLLPMSCSSCQHATFGTNGAQRHSHNNNSSDLHPHKHHSHEQHPHGHHPHAHHPHEHDTHRQHPHGHHPHGHHPHGHHPHGHHPHGHHPHCHDFQDYGPCDPPPHNQGHCCHGHGPPPGHLRRRGPGKGPRPFHCRQIGSVYRLPPLRKGEVLPLPEANFPSFPLPHHKHPLKPDNQPFPQSVSESCPGKFKSGFPQVSMFFTHTFPKA Alanin C Cisteyin D Asparaginova kislota E Glutaminova kislota F Fenilalanin G Glicin H Gistidin I Izolejcin K Lizin L Lejcin M Metionin N Asparagin P Prolin Q Glutamin R Arginin S Serin T Treonin V Valin W Triptofan Y Tirozin Zadiyanij u takih biologichnih procesah yak zsidannya krovi gemostaz angiogenez hemotaksis fibrinoliz Bilok maye sajt dlya zv yazuvannya z ionom midi ionami metaliv ionom cinku z molekuloyu geparinu Sekretovanij nazovni Literatura red Koide T Foster D C Yoshitake S Davie E W 1986 Amino acid sequence of human histidine rich glycoprotein derived from the nucleotide sequence of its cDNA Biochemistry 25 2220 2225 PubMed DOI 10 1021 bi00356a055 The status quality and expansion of the NIH full length cDNA project the Mammalian Gene Collection MGC Genome Res 14 2121 2127 2004 PubMed DOI 10 1101 gr 2596504 Morgan W T 1978 Human serum histidine rich glycoprotein I Interactions with heme metal ions and organic ligands Biochim Biophys Acta 535 319 333 PubMed DOI 10 1016 0005 2795 78 90098 3 Gorgani N N Parish C R Altin J G 1999 Differential binding of histidine rich glycoprotein HRG to human IgG subclasses and IgG molecules containing kappa and lambda light chains J Biol Chem 274 29633 29640 PubMed DOI 10 1074 jbc 274 42 29633 Jones A L Hulett M D Parish C R 2004 Histidine rich glycoprotein binds to cell surface heparan sulfate via its N terminal domain following Zn2 chelation J Biol Chem 279 30114 30122 PubMed DOI 10 1074 jbc M401996200 Jones A L Hulett M D Altin J G Hogg P Parish C R 2004 Plasminogen is tethered with high affinity to the cell surface by the plasma protein histidine rich glycoprotein J Biol Chem 279 38267 38276 PubMed DOI 10 1074 jbc M406027200Primitki red Zahvoryuvannya genetichno pov yazani z Bagatij na gistidin glikoproteyin pereglyanuti redaguvati posilannya na VikiDanih Human PubMed Reference HUGO Gene Nomenclature Commitee HGNC 5181 angl Arhiv originalu za 6 kvitnya 2016 Procitovano 30 sichnya 2017 UniProt P04196 angl Arhiv originalu za 6 listopada 2016 Procitovano 30 sichnya 2017 Div takozh red Hromosoma 3 nbsp Ce nezavershena stattya pro bilki Vi mozhete dopomogti proyektu vipravivshi abo dopisavshi yiyi Otrimano z https uk wikipedia org w index php title Bagatij na gistidin glikoproteyin amp oldid 38132994
