H2AFY angl H2A histone family member Y bilok yakij koduyetsya odnojmennim genom roztashovanim u lyudej na korotkomu plechi 5 yi hromosomi 3 Dovzhina polipeptidnogo lancyuga bilka stanovit 372 aminokislot a molekulyarna masa 39 617 4 H2AFYNayavni strukturiPDBPoshuk ortologiv PDBe RCSBSpisok kodiv PDB1U35 1ZR3 1ZR5 2F8N 2FXK 3HQH 3HSV 3IID 3IIF 3IVB 5IITIdentifikatoriSimvoliMACROH2A1 H2A y H2A y H2AF12M H2AFJ MACROH2A1 1 mH2A1 macroH2A1 2 H2A histone family member Y H2AFY macroH2A 1 histoneZovnishni ID OMIM 610054 MGI 1349392 HomoloGene 3598 GeneCards MACROH2A1Ontologiya genaMolekulyarna funkciya protein kinase binding rDNA binding protein serine threonine kinase inhibitor activity RNA polymerase II transcription regulatory region sequence specific DNA binding chromatin binding double stranded methylated DNA binding protein heterodimerization activity RNA polymerase II core promoter sequence specific DNA binding core promoter sequence specific DNA binding DNA binding chromatin DNA binding enzyme binding GO 0001948 GO 0016582 protein binding nucleosomal DNA binding promoter specific chromatin bindingKlitinna komponenta ekzosoma ESC E Z complex Yaderce condensed chromosome hromosoma pericentric heterochromatin Nukleosoma klitinne yadro nuclear chromosome sex chromatin Tilce Barra HromatinBiologichnij proces negative regulation of histone H3 K4 methylation regulation of ribosomal DNA heterochromatin assembly Dozova kompensaciya negative regulation of cell cycle G2 M phase transition epigenetic maintenance of chromatin in transcription competent conformation regulation of cell growth positive regulation of keratinocyte differentiation negative regulation of protein serine threonine kinase activity GO 1901227 negative regulation of transcription by RNA polymerase II nucleosome assembly negative regulation of protein localization to chromosome telomeric region negative regulation of gene expression epigenetic negative regulation of histone H3 K27 methylation Epigenetichne uspadkuvannya positive regulation of maintenance of mitotic sister chromatid cohesion establishment of protein localization to chromatin negative regulation of transcription of nucleolar large rRNA by RNA polymerase I regulation of lipid metabolic process regulation of response to oxidative stress negative regulation of response to oxidative stress positive regulation of response to oxidative stress GO 0031497 GO 0006336 GO 0034724 GO 0001301 GO 0007580 GO 0034652 GO 0010847 chromatin organizationDzherela Amigo QuickGOShablon ekspresiyiBilshe danihOrtologiVidi Lyudina MishaEntrez9555 26914Ensembl ENSG00000113648 ENSMUSG00000015937UniProt O75367 Q9QZQ8RefSeq mRNK NM 001040158NM 004893NM 138609NM 138610NM 001159513NM 001159514NM 001159515NM 012015RefSeq bilok NP 001035248NP 004884NP 613075NP 613258NP 001152985NP 001152986NP 001152987NP 036145Lokus UCSC Hr 5 135 33 135 4 MbHr 13 56 22 56 28 MbPubMed search 1 2 VikidaniDiv Red dlya lyudejDiv Red dlya mishej Poslidovnist aminokislot1020304050MSSRGGKKKSTKTSRSAKAGVIFPVGRMLRYIKKGHPKYRIGVGAPVYMAAVLEYLTAEILELAGNAARDNKKGRVTPRHILLAVANDEELNQLLKGVTIASGGVLPNIHPELLAKKRGSKGKLEAIITPPPAKKAKSPSQKKPVSKKAGGKKGARKSKKKQGEVSKAASADSTTEGTPADGFTVLSTKSLFLGQKLNLIHSEISNLAGFEVEAIINPTNADIDLKDDLGNTLEKKGGKEFVEAVLELRKKNGPLEVAGAAVSAGHGLPAKFVIHCNSPVWGADKCEELLEKTVKNCLALADDKKLKSIAFPSIGSGRNGFPKQTAAQLILKAISSYFVSTMSSSIKTVYFVLFDSESIGIYVQEMAKLDANA Alanin C Cisteyin D Asparaginova kislota E Glutaminova kislota F Fenilalanin G Glicin H Gistidin I Izolejcin K Lizin L Lejcin M Metionin N Asparagin P Prolin Q Glutamin R Arginin S Serin T Treonin V Valin W Triptofan Y Tirozin Kodovanij genom bilok za funkciyami nalezhit do regulyatoriv hromatinu fosfoproteyiniv Zadiyanij u takih biologichnih procesah yak acetilyuvannya alternativnij splajsing Bilok maye sajt dlya zv yazuvannya z DNK Lokalizovanij u yadri hromosomah Literatura RedaguvatiThe status quality and expansion of the NIH full length cDNA project the Mammalian Gene Collection MGC Genome Res 14 2121 2127 2004 PubMed DOI 10 1101 gr 2596504 Costanzi C Pehrson J R 1998 Histone macroH2A1 is concentrated in the inactive X chromosome of female mammals Nature 393 599 601 PubMed DOI 10 1038 31275 Kustatscher G Hothorn M Pugieux C Scheffzek K Ladurner A G 2005 Splicing regulates NAD metabolite binding to histone macroH2A Nat Struct Mol Biol 12 624 625 PubMed DOI 10 1038 nsmb956Primitki Redaguvati Human PubMed Reference Mouse PubMed Reference HUGO Gene Nomenclature Commitee HGNC 4740 angl Arhiv originalu za 17 zhovtnya 2015 Procitovano 5 veresnya 2017 UniProt O75367 angl Arhiv originalu za 25 serpnya 2017 Procitovano 5 veresnya 2017 Div takozh RedaguvatiHromosoma 5 nbsp Ce nezavershena stattya pro bilki Vi mozhete dopomogti proyektu vipravivshi abo dopisavshi yiyi Otrimano z https uk wikipedia org w index php title H2AFY amp oldid 35449425
