DCT angl Dopachrome tautomerase bilok yakij koduyetsya odnojmennim genom roztashovanim u lyudej na korotkomu plechi 13 yi hromosomi 3 Dovzhina polipeptidnogo lancyuga bilka stanovit 519 aminokislot a molekulyarna masa 59 145 4 DCTNayavni strukturiPDBPoshuk ortologiv PDBe RCSBSpisok kodiv PDB4HX1IdentifikatoriSimvoliDCT TRP 2 TYRP2 dopachrome tautomerase OCA8Zovnishni ID OMIM 191275 MGI 102563 HomoloGene 1447 GeneCards DCTOntologiya genaMolekulyarna funkciya isomerase activity zv yazuvannya z ionom metalu oxidoreductase activity copper ion binding dopachrome isomerase activityKlitinna komponenta citoplazma integral component of membrane gialoplazma membrana Melanosoma melanosome membraneBiologichnij proces positive regulation of neuroblast proliferation melanin biosynthetic process cell development ventricular zone neuroblast division melanin biosynthetic process from tyrosine epidermis development developmental pigmentation pigmentation Obmin rechovinDzherela Amigo QuickGOShablon ekspresiyiBilshe danihOrtologiVidi Lyudina MishaEntrez1638 13190Ensembl ENSG00000080166 ENSMUSG00000022129UniProt P40126 P29812RefSeq mRNK NM 001129889NM 001922NM 001322182NM 001322183NM 001322184NM 001322185NM 001322186NM 010024RefSeq bilok NP 001123361NP 001309111NP 001309112NP 001309113NP 001309114NP 001309115NP 001913NP 034154Lokus UCSC Hr 13 94 44 94 48 MbHr 14 118 25 118 29 MbPubMed search 1 2 VikidaniDiv Red dlya lyudejDiv Red dlya mishej Poslidovnist aminokislot1020304050MSPLWWGFLLSCLGCKILPGAQGQFPRVCMTVDSLVNKECCPRLGAESANVCGSQQGRGQCTEVRADTRPWSGPYILRNQDDRELWPRKFFHRTCKCTGNFAGYNCGDCKFGWTGPNCERKKPPVIRQNIHSLSPQEREQFLGALDLAKKRVHPDYVITTQHWLGLLGPNGTQPQFANCSVYDFFVWLHYYSVRDTLLGPGRPYRAIDFSHQGPAFVTWHRYHLLCLERDLQRLIGNESFALPYWNFATGRNECDVCTDQLFGAARPDDPTLISRNSRFSSWETVCDSLDDYNHLVTLCNGTYEGLLRRNQMGRNSMKLPTLKDIRDCLSLQKFDNPPFFQNSTFSFRNALEGFDKADGTLDSQVMSLHNLVHSFLNGTNALPHSAANDPIFVVLHSFTDAIFDEWMKRFNPPADAWPQELAPIGHNRMYNMVPFFPPVTNEELFLTSDQLGYSYAIDLPVSVEETPGWPTTLLVVMGTLVALVGLFVLLAFLQYRRLRKGYTPLMETHLSSKRYTEEAA Alanin C Cisteyin D Asparaginova kislota E Glutaminova kislota F Fenilalanin G Glicin H Gistidin I Izolejcin K Lizin L Lejcin M Metionin N Asparagin P Prolin Q Glutamin R Arginin S Serin T Treonin V Valin W Triptofan Y Tirozin Kodovanij genom bilok za funkciyeyu nalezhit do izomeraz Zadiyanij u takomu biologichnomu procesi yak alternativnij splajsing Bilok maye sajt dlya zv yazuvannya z ionami metaliv ionom cinku Lokalizovanij u membrani Literatura RedaguvatiYokoyama K Suzuki H Yasumoto K I Tomita Y Shibahara S 1994 Molecular cloning and functional analysis of a cDNA coding for human DOPAchrome tautomerase tyrosinase related protein 2 Biochim Biophys Acta 1217 317 321 PubMed DOI 10 1016 0167 4781 94 90292 5 Cassady J L Sturm R A 1994 Sequence of the human dopachrome tautomerase encoding TRP 2 cDNA Gene 143 295 298 PubMed DOI 10 1016 0378 1119 94 90114 7 Bouchard B del Marmol V Jackson I J Cherif D Dubertret L 1994 Molecular characterization of a human tyrosinase related protein 2 cDNA Patterns of expression in melanocytic cells Eur J Biochem 219 127 134 PubMed DOI 10 1111 j 1432 1033 1994 tb19922 x Khong H T Rosenberg S A 2002 Pre existing immunity to tyrosinase related protein TRP 2 a new TRP 2 isoform and the NY ESO 1 melanoma antigen in a patient with a dramatic response to immunotherapy J Immunol 168 951 956 PubMed DOI 10 4049 jimmunol 168 2 951 The status quality and expansion of the NIH full length cDNA project the Mammalian Gene Collection MGC Genome Res 14 2121 2127 2004 PubMed DOI 10 1101 gr 2596504 Yokoyama K Yasumoto K I Suzuki H Shibahara S 1994 Cloning of the human DOPAchrome tautomerase tyrosinase related protein 2 gene and identification of two regulatory regions required for its pigment cell specific expression J Biol Chem 269 27080 27087 PubMedPrimitki Redaguvati Human PubMed Reference Mouse PubMed Reference HUGO Gene Nomenclature Commitee HGNC 2709 angl Procitovano 11 veresnya 2017 UniProt P40126 angl Arhiv originalu za 24 veresnya 2017 Procitovano 11 veresnya 2017 Div takozh RedaguvatiHromosoma 13Na cyu stattyu ne posilayutsya inshi statti Vikipediyi Bud laska skoristajtesya pidkazkoyu ta rozstavte posilannya vidpovidno do prijnyatih rekomendacij nbsp Ce nezavershena stattya pro bilki Vi mozhete dopomogti proyektu vipravivshi abo dopisavshi yiyi Otrimano z https uk wikipedia org w index php title DCT amp oldid 38133022
