CHRNB2 angl Cholinergic receptor nicotinic beta 2 subunit bilok yakij koduyetsya odnojmennim genom roztashovanim u lyudej na korotkomu plechi 1 yi hromosomi 5 Dovzhina polipeptidnogo lancyuga bilka stanovit 502 aminokislot a molekulyarna masa 57 019 6 CHRNB2Nayavni strukturiPDBPoshuk ortologiv PDBe RCSBSpisok kodiv PDB2K58 2K59 2KSR 2LM2IdentifikatoriSimvoliCHRNB2 EFNL3 nAChRB2 cholinergic receptor nicotinic beta 2 subunitZovnishni ID OMIM 118507 MGI 87891 HomoloGene 595 GeneCards CHRNB2Pov yazani genetichni zahvoryuvannyaautosomal dominant nocturnal frontal lobe epilepsy 3 1 Reaguye na spolukupozanicline ispronicline 2 Ontologiya genaMolekulyarna funkciya acetylcholine binding acetylcholine receptor activity ion channel activity GO 0001948 GO 0016582 protein binding ligand gated ion channel activity protein heterodimerization activity extracellular ligand gated ion channel activity acetylcholine gated cation selective channel activity transmembrane signaling receptor activity transmitter gated ion channel activity involved in regulation of postsynaptic membrane potentialKlitinna komponenta acetylcholine gated channel complex integral component of membrane postsynaptic membrane membrana klitinna membrana sinaps Mizhklitinni kontakti external side of plasma membrane integral component of plasma membrane neuron projection plasma membrane raft dopaminergic synapse cholinergic synapse integral component of presynaptic membrane integral component of postsynaptic specialization membraneBiologichnij proces visual learning regulation of synaptic transmission dopaminergic response to cocaine smooth muscle contraction regulation of circadian sleep wake cycle REM sleep regulation of dopamine secretion response to hypoxia associative learning kognitivnist locomotory behavior protein heterooligomerization central nervous system neuron axonogenesis optic nerve morphogenesis regulation of synapse assembly regulation of membrane potential response to nicotine membrane depolarization nervous system process synaptic transmission cholinergic ion transport sensory perception of sound navchennya pam yat negative regulation of action potential regulation of dopamine metabolic process behavioral response to nicotine regulation of dendrite morphogenesis B cell activation neuromuscular synaptic transmission synaptic transmission involved in micturition positive regulation of dopamine secretion positive regulation of B cell proliferation regulation of circadian sleep wake cycle non REM sleep vestibulocochlear nerve development conditioned taste aversion GO 0015915 transport socialna povedinka potencial diyi sensory perception of pain lateral geniculate nucleus development positive regulation of synaptic transmission dopaminergic response to ethanol central nervous system projection neuron axonogenesis calcium ion transport GO 0072468 Signalna transdukciya zir ion transmembrane transport regulation of postsynaptic membrane potential excitatory postsynaptic potential acetylcholine receptor signaling pathway chemical synaptic transmission response to acetylcholine regulation of synaptic vesicle exocytosisDzherela Amigo QuickGOShablon ekspresiyiBilshe danihOrtologiVidi Lyudina MishaEntrez1141 11444Ensembl ENSG00000160716 ENSMUSG00000027950UniProt P17787 Q9ERK7RefSeq mRNK NM 000748NM 009602RefSeq bilok NP 000739NP 033732Lokus UCSC Hr 1 154 57 154 58 MbHr 3 89 65 89 67 MbPubMed search 3 4 VikidaniDiv Red dlya lyudejDiv Red dlya mishej Poslidovnist aminokislot1020304050MARRCGPVALLLGFGLLRLCSGVWGTDTEERLVEHLLDPSRYNKLIRPATNGSELVTVQLMVSLAQLISVHEREQIMTTNVWLTQEWEDYRLTWKPEEFDNMKKVRLPSKHIWLPDVVLYNNADGMYEVSFYSNAVVSYDGSIFWLPPAIYKSACKIEVKHFPFDQQNCTMKFRSWTYDRTEIDLVLKSEVASLDDFTPSGEWDIVALPGRRNENPDDSTYVDITYDFIIRRKPLFYTINLIIPCVLITSLAILVFYLPSDCGEKMTLCISVLLALTVFLLLISKIVPPTSLDVPLVGKYLMFTMVLVTFSIVTSVCVLNVHHRSPTTHTMAPWVKVVFLEKLPALLFMQQPRHHCARQRLRLRRRQREREGAGALFFREAPGADSCTCFVNRASVQGLAGAFGAEPAPVAGPGRSGEPCGCGLREAVDGVRFIADHMRSEDDDQSVSEDWKYVAMVIDRLFLWIFVFVCVFGTIGMFLQPLFQNYTTTTFLHSDHSAPSSKA Alanin C Cisteyin D Asparaginova kislota E Glutaminova kislota F Fenilalanin G Glicin H Gistidin I Izolejcin K Lizin L Lejcin M Metionin N Asparagin P Prolin Q Glutamin R Arginin S Serin T Treonin V Valin W Triptofan Y Tirozin Kodovanij genom bilok za funkciyami nalezhit do receptoriv ionnih kanaliv Zadiyanij u takih biologichnih procesah yak transport ioniv transport polimorfizm Lokalizovanij u klitinnij membrani membrani klitinnih kontaktah sinapsah Literatura red Anand R Lindstrom J 1990 Nucleotide sequence of the human nicotinic acetylcholine receptor beta 2 subunit gene Nucleic Acids Res 18 4272 4272 PubMed DOI 10 1093 nar 18 14 4272 Groot Kormelink P J Luyten W H M L 1997 Cloning and sequence of full length cDNAs encoding the human neuronal nicotinic acetylcholine receptor nAChR subunits beta3 and beta4 and expression of seven nAChR subunits in the human neuroblastoma cell line SH SY5Y and or IMR 32 FEBS Lett 400 309 314 PubMed DOI 10 1016 S0014 5793 96 01383 X Rempel N Heyers S Engels H Sleegers E Steinlein O K 1998 The structures of the human neuronal nicotinic acetylcholine receptor beta2 and alpha3 subunit genes CHRNB2 and CHRNA3 Hum Genet 103 645 653 PubMed DOI 10 1007 s004390050885 The status quality and expansion of the NIH full length cDNA project the Mammalian Gene Collection MGC Genome Res 14 2121 2127 2004 PubMed DOI 10 1101 gr 2596504 Kouvatsos N Giastas P Chroni Tzartou D Poulopoulou C Tzartos S J 2016 Crystal structure of a human neuronal nAChR extracellular domain in pentameric assembly Ligand bound alpha2 homopentamer Proc Natl Acad Sci U S A 113 9635 9640 PubMed DOI 10 1073 PNAS 1602619113 Bondarenko V Tillman T Xu Y Tang P 2010 NMR structure of the transmembrane domain of the n acetylcholine receptor beta2 subunit Biochim Biophys Acta 1798 1608 1614 PubMed DOI 10 1016 j bbamem 2010 04 014Primitki red Zahvoryuvannya genetichno pov yazani z CHRNB2 pereglyanuti redaguvati posilannya na VikiDanih Spoluki yaki fizichno vzayemodiyut z Cholinergic receptor nicotinic beta 2 subunit pereglyanuti redaguvati posilannya na VikiDanih Human PubMed Reference Mouse PubMed Reference HUGO Gene Nomenclature Commitee HGNC 1962 angl Procitovano 25 serpnya 2017 UniProt P17787 angl Arhiv originalu za 3 sichnya 2018 Procitovano 25 serpnya 2017 Div takozh red Hromosoma 1 nbsp Ce nezavershena stattya pro bilki Vi mozhete dopomogti proyektu vipravivshi abo dopisavshi yiyi Otrimano z https uk wikipedia org w index php title CHRNB2 amp oldid 38132890
