CCR2 angl C C motif chemokine receptor 2 bilok yakij koduyetsya odnojmennim genom roztashovanim u lyudej na korotkomu plechi 3 yi hromosomi 3 Dovzhina polipeptidnogo lancyuga bilka stanovit 374 aminokislot a molekulyarna masa 41 915 4 CCR2Nayavni strukturiPDBPoshuk ortologiv PDBe RCSBSpisok kodiv PDB1KAD 1KP1IdentifikatoriSimvoliCCR2 CC CKR 2 CCR 2 CCR2A CCR2B CD192 CKR2 CKR2A CKR2B CMKBR2 MCP 1 R C C motif chemokine receptor 2Zovnishni ID OMIM 601267 MGI 106185 HomoloGene 537 GeneCards CCR2Ontologiya genaMolekulyarna funkciya CCR2 chemokine receptor binding G protein coupled receptor activity protein homodimerization activity signal transducer activity chemokine receptor activity C C chemokine receptor activity GO 0001948 GO 0016582 protein binding GO 0019974 cytokine binding chemokine C C motif ligand 2 binding chemokine C C motif ligand 12 binding chemokine C C motif ligand 7 binding chemokine binding C C chemokine bindingKlitinna komponenta integral component of membrane Perikarion membrana klitinna membrana integral component of plasma membrane neuronal cell body Dendrit nejrobiologiya perinuclear region of cytoplasm citoplazma gialoplazma external side of plasma membraneBiologichnij proces negative regulation of adenylate cyclase activity receptor signaling pathway via JAK STAT chemokine mediated signaling pathway cellular calcium ion homeostasis positive regulation of monocyte chemotaxis dendritic cell chemotaxis hemotaksis blood vessel remodeling response to wounding GO 0046730 GO 0046737 GO 0046738 GO 0046736 Imunna vidpovid inflammatory response GO 0022415 viral process positive regulation of astrocyte chemotaxis GO 0072468 Signalna transdukciya positive regulation of cytosolic calcium ion concentration G protein coupled receptor signaling pathway monocyte chemotaxis positive regulation of T helper 1 type immune response negative regulation of type 2 immune response humoral immune response cellular defense response regulation of vascular endothelial growth factor production positive regulation of T cell chemotaxis negative regulation of angiogenesis sensory perception of pain cellular homeostasis regulation of cell migration positive regulation of interferon gamma production positive regulation of interleukin 2 production T helper 17 cell chemotaxis negative regulation of eosinophil degranulation positive regulation of alpha beta T cell proliferation homeostasis of number of cells within a tissue positive regulation of inflammatory response positive regulation of T cell activation leukocyte adhesion to vascular endothelial cell positive regulation of immune complex clearance by monocytes and macrophages neutrophil clearance positive regulation of leukocyte tethering or rolling positive regulation of monocyte extravasation positive regulation of CD8 positive alpha beta T cell extravasation positive regulation of hematopoietic stem cell migration cytokine mediated signaling pathway krovotvorennya calcium mediated signaling cell chemotaxis positive regulation of cold induced thermogenesis regulation of T cell cytokine production monocyte extravasation regulation of T cell differentiation regulation of inflammatory response positive regulation of synaptic transmission glutamatergic inflammatory response to wounding macrophage migration positive regulation of thymocyte migration positive regulation of NMDA glutamate receptor activityDzherela Amigo QuickGOOrtologiVidi Lyudina MishaEntrez729230 12772Ensembl ENSG00000121807 ENSMUSG00000049103UniProt P41597 P51683RefSeq mRNK NM 001123041NM 001123396NM 009915RefSeq bilok NP 001116513NP 001116868NP 001116868 1NP 034045Lokus UCSC Hr 3 46 35 46 36 MbHr 9 123 9 123 91 MbPubMed search 1 2 VikidaniDiv Red dlya lyudejDiv Red dlya mishej Poslidovnist aminokislot1020304050MLSTSRSRFIRNTNESGEEVTTFFDYDYGAPCHKFDVKQIGAQLLPPLYSLVFIFGFVGNMLVVLILINCKKLKCLTDIYLLNLAISDLLFLITLPLWAHSAANEWVFGNAMCKLFTGLYHIGYFGGIFFIILLTIDRYLAIVHAVFALKARTVTFGVVTSVITWLVAVFASVPGIIFTKCQKEDSVYVCGPYFPRGWNNFHTIMRNILGLVLPLLIMVICYSGILKTLLRCRNEKKRHRAVRVIFTIMIVYFLFWTPYNIVILLNTFQEFFGLSNCESTSQLDQATQVTETLGMTHCCINPIIYAFVGEKFRSLFHIALGCRIAPLQKPVCGGPGVRPGKNVKVTTQGLLDGRGKGKSIGRAPEASLQDKEGAA Alanin C Cisteyin D Asparaginova kislota E Glutaminova kislota F Fenilalanin G Glicin H Gistidin I Izolejcin K Lizin L Lejcin M Metionin N Asparagin P Prolin Q Glutamin R Arginin S Serin T Treonin V Valin W Triptofan Y Tirozin Kodovanij genom bilok za funkciyami nalezhit do receptoriv g bilokspryazhenih receptoriv bilkiv vnutrishnoklitinnogo signalingu fosfoproteyiniv Zadiyanij u takih biologichnih procesah yak vzayemodiya hazyayin virus polimorfizm alternativnij splajsing Lokalizovanij u klitinnij membrani membrani Literatura red Yamagami S Tokuda Y Ishii K Tamaka H Endo N 1994 cDNA cloning and functional expression of a human monocyte chemoattractant protein 1 receptor Biochem Biophys Res Commun 202 1156 1162 PubMed DOI 10 1006 bbrc 1994 2049 The status quality and expansion of the NIH full length cDNA project the Mammalian Gene Collection MGC Genome Res 14 2121 2127 2004 PubMed DOI 10 1101 gr 2596504 Sung H J Kim Y S Kang H Ko J 2008 Human LZIP induces monocyte CC chemokine receptor 2 expression leading to enhancement of monocyte chemoattractant protein 1 CCL2 induced cell migration Exp Mol Med 40 332 338 PubMed DOI 10 3858 emm 2008 40 3 332Primitki red Human PubMed Reference Mouse PubMed Reference HUGO Gene Nomenclature Commitee HGNC 1603 angl Arhiv originalu za 30 kvitnya 2017 Procitovano 30 serpnya 2017 UniProt P41597 angl Arhiv originalu za 8 serpnya 2017 Procitovano 30 serpnya 2017 Div takozh red Hromosoma 3 nbsp Ce nezavershena stattya pro bilki Vi mozhete dopomogti proyektu vipravivshi abo dopisavshi yiyi Otrimano z https uk wikipedia org w index php title CCR2 amp 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