Trombin aktivovanij faktor zsidannya krovi II fibrinogenase thrombase thrombofort topical thrombin C tropostasin activated blood coagulation factor II blood coagulation factor IIa factor IIa E thrombin beta thrombin gamma thrombin bilok yakij koduyetsya genom F2 roztashovanim u lyudej na korotkomu plechi 11 yi hromosomi 5 6 Dovzhina polipeptidnogo lancyuga bilka stanovit 622 aminokislot a molekulyarna masa 70 037 7 Trombin vazhlivij komponent sistemi zgortannya krovi lyudini i tvarin Trombin KF 3 4 21 5 8 vidnositsya do fermentiv klasu gidrolaz grupi serinovih proteaz ta katalizuye gidroliz peptidnih zv yazkiv utvorenih zalishkami argininu i lizinu maye obmezhenu substratnu specifichnist TrombinNayavni strukturiPDBPoshuk ortologiv PDBe RCSBSpisok kodiv PDB1A2C 1A3B 1A3E 1ABI 1ABJ 1AD8 1AE8 1AI8 1AIX 1AWF 1AWH 1AY6 1B5G 1B7X 1BA8 1BB0 1BCU 1BHX 1BMM 1BMN 1BTH 1C1U 1C1V 1C1W 1C4U 1C4V 1C4Y 1C5L 1C5N 1C5O 1CA8 1D3D 1D3P 1D3Q 1D3T 1D4P 1D6W 1D9I 1DE7 1DIT 1DM4 1DOJ 1DWB 1DWC 1DWD 1DX5 1E0F 1EB1 1EOJ 1EOL 1FPC 1G30 1G32 1G37 1GHV 1GHW 1GHX 1GHY 1GJ4 1GJ5 1H8D 1H8I 1HAI 1HAO 1HAP 1HBT 1HLT 1HUT 1HXE 1HXF 1IHS 1JMO 1JOU 1JWT 1K21 1K22 1KTS 1KTT 1LHC 1LHD 1LHE 1LHF 1LHG 1MH0 1MU6 1MU8 1MUE 1NM6 1NRN 1NRO 1NRP 1NRQ 1NRR 1NRS 1NT1 1NU7 1NU9 1NY2 1NZQ 1O0D 1O2G 1O5G 1OOK 1OYT 1P8V 1PPB 1QBV 1QHR 1QJ1 1QJ6 1QJ7 1QUR 1RD3 1RIW 1SB1 1SFQ 1SG8 1SGI 1SHH 1SL3 1SR5 1T4U 1T4V 1TA2 1TA6 1TB6 1THP 1THR 1THS 1TMB 1TMU 1TOM 1TQ0 1TQ7 1TWX 1UVS 1VR1 1VZQ 1W7G 1WAY 1WBG 1XM1 1XMN 1YPE 1YPG 1YPJ 1YPK 1YPL 1YPM 1Z71 1Z8I 1Z8J 1ZGI 1ZGV 1ZRB 2A0Q 2A2X 2A45 2AFQ 2ANK 2ANM 2B5T 2BDY 2BVR 2BVS 2BVX 2BXT 2BXU 2C8Y 2FEQ 2FES 2GDE 2GP9 2H9T 2HGT 2HNT 2HPP 2HPQ 2HWL 2JH0 2JH6 2OD3 2PGB 2PGQ 2PW8 2R2M 2THF 2ZFQ 2ZFR 2ZG0 2ZHE 2ZHF 2ZHW 2ZI2 2ZIQ 2ZNK 2ZO3 3B23 3B9F 3BEF 3BEI 3BF6 3BIU 3BIV 3BV9 3C1K 3C27 3D49 3DA9 3DD2 3DT0 3DUX 3E6P 3EE0 3EQ0 3F68 3GIC 3GIS 3HAT 3HKJ 3HTC 3JZ2 3LDX 3LU9 3NXP 3P17 3P6Z 3P70 3PO1 3QGN 3QLP 3QTO 3QTV 3QWC 3QX5 3R3G 3RLW 3RLY 3RM0 3RM2 3RML 3RMM 3RMN 3RMO 3S7H 3S7K 3SHA 3SHC 3SI3 3SI4 3SQE 3SQH 3SV2 3T5F 3TU7 3U69 3U8O 3U8R 3U8T 3U98 3U9A 3UTU 3UWJ 3VXE 3VXF 4BAH 4BAK 4BAM 4BAN 4BAO 4BAQ 4BOH 4DIH 4DII 4DT7 4DY7 4E05 4E06 4E7R 4H6S 4H6T 4HFP 4HTC 4THN 5GDS 7KME 8KME 1A46 1A4W 1A5G 1A61 1AFE 1AHT 1DWE 1FPH 1HAG 1HAH 1HDT 1HGT 1IHT 1NO9 1TBZ 1TMT 1UMA 2C8W 2C8X 2C8Z 2C90 2C93 2CF8 2CF9 2CN0 2JH5 2PKS 2UUF 2UUJ 2UUK 2V3H 2V3O 2ZC9 2ZDA 2ZDV 2ZF0 2ZFF 2ZFP 2ZGB 2ZGX 2ZHQ 3DHK 3EGK 3JZ1 3K65 3PMH 3QDZ 4AX9 4AYV 4AYY 4AZ2 4CH2 4CH8 4HZH 4I7Y 4LOY 4LXB 4LZ1 4LZ4 4MLF 4N3L 4NZE 4NZQ 4O03 4RKJ 4RKO 4RN6 4YES 4UD9 4UDW 4UE7 4UEH 5AF9 5AFY 5AFZ 5AHG 5CMX 4UFD 5EDM 5E8E 5EDK 4UFE 4UFG 4UFF 5A2M 5JDUIdentifikatoriSimvoliF2 PT RPRGL2 THPH1 coagulation factor II thrombinZovnishni ID OMIM 176930 MGI 88380 HomoloGene 426 GeneCards F2Pov yazani genetichni zahvoryuvannyahypoprothrombinemia thrombophilia 1 Reaguye na spolukuDabigatran ximelagatran dabigatran etexilate argatroban 2 Ontologiya genaMolekulyarna funkciya calcium ion binding signaling receptor binding GO 0070122 peptidase activity hydrolase activity growth factor activity serine type peptidase activity thrombospondin receptor activity GO 0001948 GO 0016582 protein binding serine type endopeptidase activity lipopolysaccharide binding heparin binding GO 0010577 enzyme activator activityKlitinna komponenta ekzosoma blood microparticle endoplasmic reticulum lumen Golgi lumen klitinna membrana extracellular region extracellular space external side of plasma membrane collagen containing extracellular matrixBiologichnij proces blood coagulation intrinsic pathway regulation of blood coagulation positive regulation of phosphatidylinositol 3 kinase signaling positive regulation of collagen biosynthetic process multicellular organism development peptidyl glutamic acid carboxylation acute phase response positive regulation of reactive oxygen species metabolic process endoplasmic reticulum to Golgi vesicle mediated transport positive regulation of cell growth cell surface receptor signaling pathway Regulyaciya ekspresiyi geniv positive regulation of release of sequestered calcium ion into cytosol positive regulation of cell population proliferation leukocyte migration negative regulation of fibrinolysis positive regulation of blood coagulation regulation of cytosolic calcium ion concentration response to wounding signal peptide processing positive regulation of phospholipase C activating G protein coupled receptor signaling pathway regulation of cell shape gemostaz negative regulation of proteolysis negative regulation of platelet activation negative regulation of astrocyte differentiation positive regulation of protein phosphorylation Fibrinoliz zsidannya krovi proteoliz platelet activation positive regulation of protein localization to nucleus positive regulation of lipid kinase activity regulation of complement activation antimicrobial humoral immune response mediated by antimicrobial peptide negative regulation of cytokine production involved in inflammatory response regulation of signaling receptor activity G protein coupled receptor signaling pathway positive regulation of receptor signaling pathway via JAK STAT blood coagulation fibrin clot formationDzherela Amigo QuickGOShablon ekspresiyiBilshe danihOrtologiVidi Lyudina MishaEntrez2147 14061Ensembl ENSG00000180210 ENSMUSG00000027249UniProt P00734 P19221RefSeq mRNK NM 000506NM 001311257NM 010168RefSeq bilok NP 000497NP 034298Lokus UCSC Hr 11 46 72 46 74 MbHr 2 91 46 91 47 MbPubMed search 3 4 VikidaniDiv Red dlya lyudejDiv Red dlya mishejTrombin v kompleksi z ingibitorom Poslidovnist aminokislot1020304050MAHVRGLQLPGCLALAALCSLVHSQHVFLAPQQARSLLQRVRRANTFLEEVRKGNLERECVEETCSYEEAFEALESSTATDVFWAKYTACETARTPRDKLAACLEGNCAEGLGTNYRGHVNITRSGIECQLWRSRYPHKPEINSTTHPGADLQENFCRNPDSSTTGPWCYTTDPTVRRQECSIPVCGQDQVTVAMTPRSEGSSVNLSPPLEQCVPDRGQQYQGRLAVTTHGLPCLAWASAQAKALSKHQDFNSAVQLVENFCRNPDGDEEGVWCYVAGKPGDFGYCDLNYCEEAVEEETGDGLDEDSDRAIEGRTATSEYQTFFNPRTFGSGEADCGLRPLFEKKSLEDKTERELLESYIDGRIVEGSDAEIGMSPWQVMLFRKSPQELLCGASLISDRWVLTAAHCLLYPPWDKNFTENDLLVRIGKHSRTRYERNIEKISMLEKIYIHPRYNWRENLDRDIALMKLKKPVAFSDYIHPVCLPDRETAASLLQAGYKGRVTGWGNLKETWTANVGKGQPSVLQVVNLPIVERPVCKDSTRIRITDNMFCAGYKPDEGKRGDACEGDSGGPFVMKSPFNNRWYQMGIVSWGEGCDRDGKYGFYTHVFRLKKWIQKVIDQFGEA Alanin C Cisteyin D Asparaginova kislota E Glutaminova kislota F Fenilalanin G Glicin H Gistidin I Izolejcin K Lizin L Lejcin M Metionin N Asparagin P Prolin Q Glutamin R Arginin S Serin T Treonin V Valin W Triptofan Y Tirozin Cej bilok za funkciyami nalezhit do gidrolaz proteaz serinovih proteaz Zadiyanij u takih biologichnih procesah yak zsidannya krovi gemostaz gostra faza zapalennya Bilok maye sajt dlya zv yazuvannya z ionom kalciyu Sekretovanij nazovni Div takozh RedaguvatiHromosoma 11 Zsidannya krovi TrombomodulinPrimitki Redaguvati Zahvoryuvannya genetichno pov yazani z Trombin pereglyanuti redaguvati posilannya na VikiDanih Spoluki yaki fizichno vzayemodiyut z Trombin pereglyanuti redaguvati posilannya na VikiDanih Human PubMed Reference Mouse PubMed Reference HUGO Gene Nomenclature Commitee HGNC 3535 angl Procitovano 5 zhovtnya 2018 Royle NJ Irwin DM Koschinsky ML MacGillivray RT Hamerton JL May 1987 Human genes encoding prothrombin and ceruloplasmin map to 11p11 q12 and 3q21 24 respectively Somat Cell Mol Genet 13 3 285 92 PMID 3474786 doi 10 1007 BF01535211 UniProt P00734 angl Procitovano 5 zhovtnya 2018 3 4 21 5 angl Literatura RedaguvatiDegen S J F Davie E W 1987 Nucleotide sequence of the gene for human prothrombin Biochemistry 26 6165 6177 PubMed DOI 10 1021 bi00393a033 The status quality and expansion of the NIH full length cDNA project the Mammalian Gene Collection MGC Genome Res 14 2121 2127 2004 PubMed DOI 10 1101 gr 2596504 Degen S J F McGillivray R T A Davie E W 1983 Characterization of the complementary deoxyribonucleic acid and gene coding for human prothrombin Biochemistry 22 2087 2097 PubMed DOI 10 1021 bi00278a008 Walz D A Hewett Emmett D Seegers W H 1977 Amino acid sequence of human prothrombin fragments 1 and 2 Proc Natl Acad Sci U S A 74 1969 1972 PubMed DOI 10 1073 pnas 74 5 1969 Casas J P Hingorani A D Bautista L E Sharma P 2004 Meta analysis of genetic studies in ischemic stroke thirty two genes involving approximately 18 000 cases and 58 000 controls Arch Neurol 61 1652 1661 PubMed DOI 10 1001 archneur 61 11 1652 Bunkenborg J Pilch B J Podtelejnikov A V Wisniewski J R 2004 Screening for N glycosylated proteins by liquid chromatography mass spectrometry Proteomics 4 454 465 PubMed DOI 10 1002 pmic 200300556 nbsp Ce nezavershena stattya pro bilki Vi mozhete dopomogti proyektu vipravivshi abo dopisavshi yiyi Otrimano z https uk wikipedia org w index php title Trombin amp oldid 36979664
