Lizocim angl Lysozyme muramidaza abo N acetilmuramidklikangidrolaza KF 3 2 1 17 bilok yakij koduyetsya genom LYZ roztashovanim u lyudini na dovgomu plechi 12 yi hromosomi 1 2 3 Dovzhina polipeptidnogo lancyuga bilka stanovit 148 aminokislot a molekulyarna masa 16 537 4 LizocimIdentifikatoriSimvoliGlyco hydro 22 lysIPR000974lysozymeLysozyme1 4 N AcetylmuramidaseDelvozymeGlobulin G1Lydium KLPMucopeptide glucohydrolaseMuramidaseN O DiacetylmuramidasePeptidoglycan N acetylmuramoylhydrolasemucopeptide N acetylmuramoylhydrolaseZovnishni ID OMIM 105200 GeneCards 1 OrtologiVidi Lyudina MishaEntrezn d n dEnsembl n d n dUniProt n d n dRefSeq mRNK n dn dRefSeq bilok n dn dLokus UCSC n dn dPubMed search n dn dVikidaniDiv Red dlya lyudej Poslidovnist aminokislot1020304050MKALIVLGLVLLSVTVQGKVFERCELARTLKRLGMDGYRGISLANWMCLAKWESGYNTRATNYNAGDRSTDYGIFQINSRYWCNDGKTPGAVNACHLSCSALLQDNIADAVACAKRVVRDPQGIRAWVAWRNRCQNRDVRQYVQGCGVA Alanin C Cisteyin D Asparaginova kislota E Glutaminova kislota F Fenilalanin G Glicin H Gistidin I Izolejcin K Lizin L Lejcin M Metionin N Asparagin P Prolin Q Glutamin R Arginin S Serin T Treonin V Valin W Triptofan Y Tirozin Cej bilok ye fermentom sho rujnuye klitinnu stinku bakterij shlyahom katalizu reakciyi gidrolizu 1 4 beta zv yazkiv mizh zalishkami N acetilmuramovoyi kisloti i N acetil D glyukozaminom u skladi glikanovogo lancyuzhka peptidoglikanu ta mizh zalishkami N acetil D glyukozaminu v skladi hitodekstrinu Lizocim u velikij kilkosti mistitsya v bagatoh sekretah tvarin takih yak slozi slina i sliz Lizocim takozh mistitsya u citoplazmenih granulah polimorfoyadernih nejtrofiliv U velikij kilkosti cej ferment takozh prisutnij u bilkah yayec Lizocimi C tipu blizko pov yazani z alfa laktalbuminom yak za nukleotidnoyu poslidovnistyu geniv tak i za svoyeyu strukturoyu sho robit yih chlenami odniyeyi rodini Lizocim vidkriv 1921 roku Aleksander Fleming pershovidkrivach penicilinu Vin pomistiv na tverde agarizovane seredovishe trohi slizu iz nosa a cherez kilka tizhniv pomitiv sho rist bakterij navkolo slizu buv prignichenij Piznishe vchenij vidiliv samu antibakterijnu rechovinu lizocim 5 Literatura RedaguvatiCastanon M J Spevak W Adolf G R Chlebowicz Sledziewska E Sledziewski A 1988 Cloning of human lysozyme gene and expression in the yeast Saccharomyces cerevisiae Gene 66 223 234 PubMed DOI 10 1016 0378 1119 88 90359 9 Chung L P Keshav S Gordon S 1988 Cloning the human lysozyme cDNA inverted Alu repeat in the mRNA and in situ hybridization for macrophages and Paneth cells Proc Natl Acad Sci U S A 85 6227 6231 PubMed DOI 10 1073 pnas 85 17 6227 Yoshimura K Toibana A Nakahama K 1988 Human lysozyme sequencing of a cDNA and expression and secretion by Saccharomyces cerevisiae Biochem Biophys Res Commun 150 794 801 PubMed DOI 10 1016 0006 291X 88 90461 5 Peters C W B Kruse U Pollwein R Grzeschik K H Sippel A E 1989 The human lysozyme gene Sequence organization and chromosomal localization Eur J Biochem 182 507 516 PubMed DOI 10 1111 j 1432 1033 1989 tb14857 x The status quality and expansion of the NIH full length cDNA project the Mammalian Gene Collection MGC Genome Res 14 2121 2127 2004 PubMed DOI 10 1101 gr 2596504 Thomsen J Lund E H Kristiansen K Brunfeldt K Malmquist J 1972 A Val Val sequence found in a human monocytic leukemia lysozyme FEBS Lett 22 34 36 PubMed DOI 10 1016 0014 5793 72 80212 6Primitki Redaguvati HUGO Gene Nomenclature Commitee HGNC 6740 angl Arhiv originalu za 26 sichnya 2017 Procitovano 30 listopada 2018 Yoshimura K Toibana A Nakahama K January 1988 Human lysozyme sequencing of a cDNA and expression and secretion by Saccharomyces cerevisiae Biochem Biophys Res Commun 150 2 794 801 PMID 2829884 doi 10 1016 0006 291X 88 90461 5 Peters CW Kruse U Pollwein R Grzeschik KH Sippel AE July 1989 The human lysozyme gene Sequence organization and chromosomal localization Eur J Biochem 182 3 507 16 PMID 2546758 doi 10 1111 j 1432 1033 1989 tb14857 x UniProt P61626 angl Arhiv originalu za 21 grudnya 2018 Procitovano 30 listopada 2018 Alexander Fleming 1881 1955 A noble life in science The British Library Board Arhiv originalu za 23 veresnya 2014 Procitovano 2 lyutogo 2014 Div takozh RedaguvatiHromosoma 12 nbsp Ce nezavershena stattya pro bilki Vi mozhete dopomogti proyektu vipravivshi abo dopisavshi yiyi Otrimano z https uk wikipedia org w index php title Lizocim amp oldid 38242101
