Komponent 6 sistemi komplementu angl Complement C6 bilok yakij koduyetsya genom C6 roztashovanim u lyudej na korotkomu plechi 5 yi hromosomi 4 Dovzhina polipeptidnogo lancyuga bilka stanovit 934 aminokislot a molekulyarna masa 104 786 5 Komponent 6 sistemi komplementuNayavni strukturiPDBPoshuk dlya lyudej PDBe RCSBSpisok kodiv PDB3T5O 4A5W 4E0SIdentifikatoriSimvoliC6 complement C6Zovnishni ID OMIM 217050 MGI 88233 HomoloGene 47 GeneCards C6Pov yazani genetichni zahvoryuvannyacomplement component 9 deficiency 1 Ontologiya genaMolekulyarna funkciya GO 0001948 GO 0016582 protein bindingKlitinna komponenta extracellular region ekzosoma membrane attack complexBiologichnij proces positive regulation of activation of membrane attack complex immune system process complement activation in utero embryonic development Citoliz regulation of complement activation GO 0046730 GO 0046737 GO 0046738 GO 0046736 Imunna vidpovid positive regulation of angiogenesis complement activation classical pathway positive regulation of complement activation Vrodzhenij imunitetDzherela Amigo QuickGOOrtologiVidi Lyudina MishaEntrez729 12274Ensembl ENSG00000039537 ENSMUSG00000022181UniProt P13671 n dRefSeq mRNK NM 000065NM 001115131NM 016704RefSeq bilok NP 000056NP 001108603n dLokus UCSC Hr 5 41 14 41 26 MbHr 15 4 76 4 84 MbPubMed search 2 3 VikidaniDiv Red dlya lyudejDiv Red dlya mishej Poslidovnist aminokislot1020304050MARRSVLYFILLNALINKGQACFCDHYAWTQWTSCSKTCNSGTQSRHRQIVVDKYYQENFCEQICSKQETRECNWQRCPINCLLGDFGPWSDCDPCIEKQSKVRSVLRPSQFGGQPCTAPLVAFQPCIPSKLCKIEEADCKNKFRCDSGRCIARKLECNGENDCGDNSDERDCGRTKAVCTRKYNPIPSVQLMGNGFHFLAGEPRGEVLDNSFTGGICKTVKSSRTSNPYRVPANLENVGFEVQTAEDDLKTDFYKDLTSLGHNENQQGSFSSQGGSSFSVPIFYSSKRSENINHNSAFKQAIQASHKKDSSFIRIHKVMKVLNFTTKAKDLHLSDVFLKALNHLPLEYNSALYSRIFDDFGTHYFTSGSLGGVYDLLYQFSSEELKNSGLTEEEAKHCVRIETKKRVLFAKKTKVEHRCTTNKLSEKHEGSFIQGAEKSISLIRGGRSEYGAALAWEKGSSGLEEKTFSEWLESVKENPAVIDFELAPIVDLVRNIPCAVTKRNNLRKALQEYAAKFDPCQCAPCPNNGRPTLSGTECLCVCQSGTYGENCEKQSPDYKSNAVDGQWGCWSSWSTCDATYKRSRTRECNNPAPQRGGKRCEGEKRQEEDCTFSIMENNGQPCINDDEEMKEVDLPEIEADSGCPQPVPPENGFIRNEKQLYLVGEDVEISCLTGFETVGYQYFRCLPDGTWRQGDVECQRTECIKPVVQEVLTITPFQRLYRIGESIELTCPKGFVVAGPSRYTCQGNSWTPPISNSLTCEKDTLTKLKGHCQLGQKQSGSECICMSPEEDCSHHSEDLCVFDTDSNDYFTSPACKFLAEKCLNNQQLHFLHIGSCQDGRQLEWGLERTRLSSNSTKKESCGYDTCYDWEKCSASTSKCVCLLPPQCFKGGNQLYCVKMGSSTSEKTLNICEVGTIRCANRKMEILHPGKCLAA Alanin C Cisteyin D Asparaginova kislota E Glutaminova kislota F Fenilalanin G Glicin H Gistidin I Izolejcin K Lizin L Lejcin M Metionin N Asparagin P Prolin Q Glutamin R Arginin S Serin T Treonin V Valin W Triptofan Y Tirozin Zadiyanij u takih biologichnih procesah yak imunitet vrodzhenij imunitet shlyah aktivaciyi komplementu citoliz Sekretovanij nazovni Literatura red Hobart M J Fernie B Discipio R G 1993 Structure of the human C6 gene Biochemistry 32 6198 6205 PubMed DOI 10 1021 bi00075a012 The status quality and expansion of the NIH full length cDNA project the Mammalian Gene Collection MGC Genome Res 14 2121 2127 2004 PubMed DOI 10 1101 gr 2596504 Chakravarti D N Chakravarti B Parra C A Mueller Eberhard H J 1989 Structural homology of complement protein C6 with other channel forming proteins of complement Proc Natl Acad Sci U S A 86 2799 2803 PubMed DOI 10 1073 pnas 86 8 2799 Lengweiler S Schaller J DiScipio R G Rickli E E 1997 Elucidation of the disulfide bonding pattern in the factor I modules of the sixth component C6 of human complement Biochim Biophys Acta 1342 13 18 PubMed DOI 10 1016 S0167 4838 97 00072 1 Hofsteenge J Blommers M Hess D Furmanek A Miroshnichenko O 1999 The four terminal components of the complement system are C mannosylated on multiple tryptophan residues J Biol Chem 274 32786 32794 PubMed DOI 10 1074 jbc 274 46 32786 Dewald G Nothen M M Cichon S 1993 Polymorphism of human complement component C6 an amino acid substitution Glu Ala within the second thrombospondin repeat differentiates between the two common allotypes C6 A and C6 B Biochem Biophys Res Commun 194 458 464 PubMed DOI 10 1006 bbrc 1993 1841Primitki red Zahvoryuvannya genetichno pov yazani z Komponent 6 sistemi komplementu pereglyanuti redaguvati posilannya na VikiDanih Human PubMed Reference Mouse PubMed Reference HUGO Gene Nomenclature Commitee HGNC 1339 angl Procitovano 27 lyutogo 2017 UniProt P13671 angl Arhiv originalu za 23 Bereznya 2017 Procitovano 27 lyutogo 2017 Div takozh red Hromosoma 5 nbsp Ce nezavershena stattya pro bilki Vi mozhete dopomogti proyektu vipravivshi abo dopisavshi yiyi Otrimano z https uk wikipedia org w index php title Komponent 6 sistemi komplementu amp oldid 38132786
