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SELP angl Selectin P bilok yakij koduyetsya odnojmennim genom roztashovanim u lyudej na korotkomu plechi 1 yi hromosomi 3 Dovzhina polipeptidnogo lancyuga bilka stanovit 830 aminokislot a molekulyarna masa 90 834 4 SELPNayavni strukturiPDBPoshuk ortologiv PDBe RCSBSpisok kodiv PDB1FSB 1G1Q 1G1R 1G1S 1HESIdentifikatoriSimvoliSELP CD62 CD62P GMP140 GRMP LECAM3 PADGEM PSEL selectin PZovnishni ID OMIM 173610 MGI 98280 HomoloGene 2260 GeneCards SELPOntologiya genaMolekulyarna funkciya heparin binding oligosaccharide binding lipopolysaccharide binding calcium dependent protein binding glycosphingolipid binding fucose binding carbohydrate binding sialic acid binding GO 0001948 GO 0016582 protein binding calcium ion binding zv yazuvannya z ionom metaluKlitinna komponenta integral component of membrane membrana platelet alpha granule membrane platelet dense granule membrane external side of plasma membrane extracellular space integral component of plasma membrane klitinna membranaBiologichnij proces leukocyte cell cell adhesion heterophilic cell cell adhesion via plasma membrane cell adhesion molecules positive regulation of leukocyte migration platelet degranulation regulation of integrin activation adgeziya klitin GO 0051636 defense response to Gram negative bacterium positive regulation of phosphatidylinositol 3 kinase signaling inflammatory response calcium mediated signaling using intracellular calcium source positive regulation of platelet activation leukocyte migration response to lipopolysaccharide calcium dependent cell cell adhesion via plasma membrane cell adhesion molecules leukocyte tethering or rollingDzherela Amigo QuickGOShablon ekspresiyiBilshe danihOrtologiVidi Lyudina MishaEntrez6403 20344Ensembl ENSG00000174175 ENSMUSG00000026580UniProt P16109 Q01102RefSeq mRNK NM 003005NM 011347RefSeq bilok NP 002996NP 002996 2NP 035477Lokus UCSC Hr 1 169 59 169 63 MbHr 1 163 94 163 98 MbPubMed search 1 2 VikidaniDiv Red dlya lyudejDiv Red dlya mishej Poslidovnist aminokislot1020304050MANCQIAILYQRFQRVVFGISQLLCFSALISELTNQKEVAAWTYHYSTKAYSWNISRKYCQNRYTDLVAIQNKNEIDYLNKVLPYYSSYYWIGIRKNNKTWTWVGTKKALTNEAENWADNEPNNKRNNEDCVEIYIKSPSAPGKWNDEHCLKKKHALCYTASCQDMSCSKQGECLETIGNYTCSCYPGFYGPECEYVRECGELELPQHVLMNCSHPLGNFSFNSQCSFHCTDGYQVNGPSKLECLASGIWTNKPPQCLAAQCPPLKIPERGNMTCLHSAKAFQHQSSCSFSCEEGFALVGPEVVQCTASGVWTAPAPVCKAVQCQHLEAPSEGTMDCVHPLTAFAYGSSCKFECQPGYRVRGLDMLRCIDSGHWSAPLPTCEAISCEPLESPVHGSMDCSPSLRAFQYDTNCSFRCAEGFMLRGADIVRCDNLGQWTAPAPVCQALQCQDLPVPNEARVNCSHPFGAFRYQSVCSFTCNEGLLLVGASVLQCLATGNWNSVPPECQAIPCTPLLSPQNGTMTCVQPLGSSSYKSTCQFICDEGYSLSGPERLDCTRSGRWTDSPPMCEAIKCPELFAPEQGSLDCSDTRGEFNVGSTCHFSCDNGFKLEGPNNVECTTSGRWSATPPTCKGIASLPTPGLQCPALTTPGQGTMYCRHHPGTFGFNTTCYFGCNAGFTLIGDSTLSCRPSGQWTAVTPACRAVKCSELHVNKPIAMNCSNLWGNFSYGSICSFHCLEGQLLNGSAQTACQENGHWSTTVPTCQAGPLTIQEALTYFGGAVASTIGLIMGGTLLALLRKRFRQKDDGKCPLNPHSHLGTYGVFTNAAFDPSPA Alanin C Cisteyin D Asparaginova kislota E Glutaminova kislota F Fenilalanin G Glicin H Gistidin I Izolejcin K Lizin L Lejcin M Metionin N Asparagin P Prolin Q Glutamin R Arginin S Serin T Treonin V Valin W Triptofan Y Tirozin Zadiyanij u takomu biologichnomu procesi yak klitinna adgeziya Bilok maye sajt dlya zv yazuvannya z lektinami Lokalizovanij u membrani Literatura red Johnston G I Cook R G McEver R P 1989 Cloning of GMP 140 a granule membrane protein of platelets and endothelium sequence similarity to proteins involved in cell adhesion and inflammation Cell 56 1033 1044 PubMed DOI 10 1016 0092 8674 89 90636 3 Pouyani T Seed B 1995 PSGL 1 recognition of P selectin is controlled by a tyrosine sulfation consensus at the PSGL 1 amino terminus Cell 83 333 343 PubMed DOI 10 1016 0092 8674 95 90174 4 Wilkins P P Moore K L McEver R P Cummings R D 1995 Tyrosine sulfation of P selectin glycoprotein ligand 1 is required for high affinity binding to P selectin J Biol Chem 270 22677 22680 PubMed DOI 10 1074 jbc 270 39 22677 Florian V Schlueter T Bohnensack R 2001 A new member of the sorting nexin family interacts with the C terminus of P selectin Biochem Biophys Res Commun 281 1045 1050 PubMed DOI 10 1006 bbrc 2001 4467 Lewandrowski U Moebius J Walter U Sickmann A 2006 Elucidation of N glycosylation sites on human platelet proteins a glycoproteomic approach Mol Cell Proteomics 5 226 233 PubMed DOI 10 1074 mcp M500324 MCP200 Kerr S C Fieger C B Snapp K R Rosen S D 2008 Endoglycan a member of the CD34 family of sialomucins is a ligand for the vascular selectins J Immunol 181 1480 1490 PubMed DOI 10 4049 jimmunol 181 2 1480Primitki red Human PubMed Reference Mouse PubMed Reference HUGO Gene Nomenclature Commitee HGNC 10721 angl Procitovano 25 serpnya 2017 UniProt P16109 angl Arhiv originalu za 8 veresnya 2017 Procitovano 25 serpnya 2017 Div takozh red Hromosoma 1 nbsp Ce nezavershena stattya pro bilki Vi mozhete dopomogti proyektu vipravivshi abo dopisavshi yiyi Otrimano z https uk wikipedia org w index php title SELP amp oldid 35722446