PIK3CA angl Phosphatidylinositol 4 5 bisphosphate 3 kinase catalytic subunit alpha bilok yakij koduyetsya odnojmennim genom roztashovanim u lyudej na korotkomu plechi 3 yi hromosomi 5 Dovzhina polipeptidnogo lancyuga bilka stanovit 1 068 aminokislot a molekulyarna masa 124 284 6 PIK3CANayavni strukturiPDBPoshuk ortologiv PDBe RCSBSpisok kodiv PDB2ENQ 2RD0 3HHM 3HIZ 3ZIM 4JPS 4L1B 4L23 4L2Y 4OVU 4OVV 4TUU 4TV3 4WAF 4YKN 5DXH 5DXT 5FI4 4ZOPIdentifikatoriSimvoliPIK3CA CLOVE CWS5 MCAP MCM MCMTC PI3K p110 alpha PI3K alpha phosphatidylinositol 4 5 bisphosphate 3 kinase catalytic subunit alpha CLAPO CCM4Zovnishni ID OMIM 171834 MGI 1206581 HomoloGene 21249 GeneCards PIK3CAshifr KF 2 7 11 1Pov yazani genetichni zahvoryuvannyakolorektalnij rak seborrheic keratosis Macrocephaly capillary malformation CLOVES syndrome CLAPO syndrome breast adenocarcinoma 1 Reaguye na spolukudactolisib idelalisib LY 294002 2 Ontologiya genaMolekulyarna funkciya transferase activity nucleotide binding protein kinase activator activity 1 phosphatidylinositol 4 phosphate 3 kinase activity protein serine threonine kinase activity GO 0001948 GO 0016582 protein binding insulin receptor substrate binding ATP binding 1 phosphatidylinositol 3 kinase activity phosphatidylinositol 4 5 bisphosphate 3 kinase activity kinase activity phosphatidylinositol 3 kinase activity phosphatidylinositol 3 4 bisphosphate 5 kinase activityKlitinna komponenta phosphatidylinositol 3 kinase complex gialoplazma phosphatidylinositol 3 kinase complex class IA klitinna membrana lamellipodium citoplazma membranaBiologichnij proces GO 1904089 negative regulation of neuron apoptotic process cardiac muscle contraction epidermal growth factor receptor signaling pathway protein kinase B signaling Fc gamma receptor signaling pathway involved in phagocytosis regulation of multicellular organism growth T cell costimulation hypomethylation of CpG island positive regulation of peptidyl serine phosphorylation platelet activation Fc epsilon receptor signaling pathway phosphatidylinositol phosphate biosynthetic process vascular endothelial growth factor receptor signaling pathway vasculature development Angiogenez insulin receptor signaling pathway via phosphatidylinositol 3 kinase glucose metabolic process Fagocitoz energy homeostasis negative regulation of fibroblast apoptotic process Regulyaciya ekspresiyi geniv liver development adipose tissue development regulation of cellular respiration T cell receptor signaling pathway activation of protein kinase activity regulation of genetic imprinting negative regulation of anoikis cellular response to glucose stimulus endothelial cell migration phosphatidylinositol mediated signaling leukocyte migration ERBB2 signaling pathway phosphatidylinositol 3 phosphate biosynthetic process axon guidance negative regulation of macroautophagy fosforilyuvannya positive regulation of TOR signaling anoikis adaptive immune response protein phosphorylation inflammatory response Vrodzhenij imunitet cell chemotaxis G protein coupled receptor signaling pathway positive regulation of protein kinase B signaling phosphatidylinositol 3 kinase signaling cytokine mediated signaling pathway cell migration positive regulation of phosphatidylinositol 3 kinase signaling phosphatidylinositol biosynthetic process regulation of protein phosphorylationDzherela Amigo QuickGOShablon ekspresiyiBilshe danihOrtologiVidi Lyudina MishaEntrez5290 18706Ensembl ENSG00000121879 ENSMUSG00000027665UniProt P42336 P42337RefSeq mRNK NM 006218NM 008839RefSeq bilok NP 006209NP 032865Lokus UCSC Hr 3 179 15 179 24 MbHr 3 32 45 32 52 MbPubMed search 3 4 VikidaniDiv Red dlya lyudejDiv Red dlya mishej Poslidovnist aminokislot1020304050MPPRPSSGELWGIHLMPPRILVECLLPNGMIVTLECLREATLITIKHELFKEARKYPLHQLLQDESSYIFVSVTQEAEREEFFDETRRLCDLRLFQPFLKVIEPVGNREEKILNREIGFAIGMPVCEFDMVKDPEVQDFRRNILNVCKEAVDLRDLNSPHSRAMYVYPPNVESSPELPKHIYNKLDKGQIIVVIWVIVSPNNDKQKYTLKINHDCVPEQVIAEAIRKKTRSMLLSSEQLKLCVLEYQGKYILKVCGCDEYFLEKYPLSQYKYIRSCIMLGRMPNLMLMAKESLYSQLPMDCFTMPSYSRRISTATPYMNGETSTKSLWVINSALRIKILCATYVNVNIRDIDKIYVRTGIYHGGEPLCDNVNTQRVPCSNPRWNEWLNYDIYIPDLPRAARLCLSICSVKGRKGAKEEHCPLAWGNINLFDYTDTLVSGKMALNLWPVPHGLEDLLNPIGVTGSNPNKETPCLELEFDWFSSVVKFPDMSVIEEHANWSVSREAGFSYSHAGLSNRLARDNELRENDKEQLKAISTRDPLSEITEQEKDFLWSHRHYCVTIPEILPKLLLSVKWNSRDEVAQMYCLVKDWPPIKPEQAMELLDCNYPDPMVRGFAVRCLEKYLTDDKLSQYLIQLVQVLKYEQYLDNLLVRFLLKKALTNQRIGHFFFWHLKSEMHNKTVSQRFGLLLESYCRACGMYLKHLNRQVEAMEKLINLTDILKQEKKDETQKVQMKFLVEQMRRPDFMDALQGFLSPLNPAHQLGNLRLEECRIMSSAKRPLWLNWENPDIMSELLFQNNEIIFKNGDDLRQDMLTLQIIRIMENIWQNQGLDLRMLPYGCLSIGDCVGLIEVVRNSHTIMQIQCKGGLKGALQFNSHTLHQWLKDKNKGEIYDAAIDLFTRSCAGYCVATFILGIGDRHNSNIMVKDDGQLFHIDFGHFLDHKKKKFGYKRERVPFVLTQDFLIVISKGAQECTKTREFERFQEMCYKAYLAIRQHANLFINLFSMMLGSGMPELQSFDDIAYIRKTLALDKTEQEALEYFMKQMNDAHHGGWTTKMDWIFHTIKQHALNA Alanin C Cisteyin D Asparaginova kislota E Glutaminova kislota F Fenilalanin G Glicin H Gistidin I Izolejcin K Lizin L Lejcin M Metionin N Asparagin P Prolin Q Glutamin R Arginin S Serin T Treonin V Valin W Triptofan Y Tirozin Kodovanij genom bilok za funkciyami nalezhit do transferaz kinaz serin treoninovih proteyinkinaz Zadiyanij u takih biologichnih procesah yak angiogenez polimorfizm Bilok maye sajt dlya zv yazuvannya z ATF nukleotidami Literatura red The status quality and expansion of the NIH full length cDNA project the Mammalian Gene Collection MGC Genome Res 14 2121 2127 2004 PubMed DOI 10 1101 gr 2596504 Huang C H Mandelker D Gabelli S B Amzel L M 2008 Insights into the oncogenic effects of PIK3CA mutations from the structure of p110alpha p85alpha Cell Cycle 7 1151 1156 PubMed DOI 10 4161 cc 7 9 5817 Zhao L Vogt P K 2008 Class I PI3K in oncogenic cellular transformation Oncogene 27 5486 5496 PubMed DOI 10 1038 onc 2008 244 Jia S Roberts T M Zhao J J 2009 Should individual PI3 kinase isoforms be targeted in cancer Curr Opin Cell Biol 21 199 208 PubMed DOI 10 1016 j ceb 2008 12 007 Hartmann C Bartels G Gehlhaar C Holtkamp N von Deimling A 2005 PIK3CA mutations in glioblastoma multiforme Acta Neuropathol 109 639 642 PubMed DOI 10 1007 s00401 005 1000 1 Oda K Stokoe D Taketani Y McCormick F 2005 High frequency of coexistent mutations of PIK3CA and PTEN genes in endometrial carcinoma Cancer Res 65 10669 10673 PubMed DOI 10 1158 0008 5472 CAN 05 2620Primitki red Zahvoryuvannya genetichno pov yazani z PIK3CA pereglyanuti redaguvati posilannya na VikiDanih Spoluki yaki fizichno vzayemodiyut z Phosphatidylinositol 4 5 bisphosphate 3 kinase catalytic subunit alpha pereglyanuti redaguvati posilannya na VikiDanih Human PubMed Reference Mouse PubMed Reference HUGO Gene Nomenclature Commitee HGNC 8975 angl Arhiv originalu za 18 kvitnya 2017 Procitovano 30 serpnya 2017 UniProt P42336 angl Arhiv originalu za 31 serpnya 2017 Procitovano 30 serpnya 2017 Div takozh red Hromosoma 3 nbsp Ce nezavershena stattya pro bilki Vi mozhete dopomogti proyektu vipravivshi abo dopisavshi yiyi Otrimano z https uk wikipedia org w index php title PIK3CA amp oldid 38120992
