AGTR1 angl Angiotensin II receptor type 1 bilok yakij koduyetsya odnojmennim genom roztashovanim u lyudej na korotkomu plechi 3 yi hromosomi 5 Dovzhina polipeptidnogo lancyuga bilka stanovit 359 aminokislot a molekulyarna masa 41 061 6 AGTR1Nayavni strukturiPDBPoshuk ortologiv PDBe RCSBSpisok kodiv PDB4YAY 4ZUDIdentifikatoriSimvoliAGTR1 AG2S AGTR1B AT1 AT1AR AT1B AT1BR AT1R AT2R1 HAT1R angiotensin II receptor type 1Zovnishni ID OMIM 106165 MGI 87964 HomoloGene 3556 GeneCards AGTR1Pov yazani genetichni zahvoryuvannyaarterialna gipertenziya 1 Reaguye na spolukuKandesartan Eprosartan Irbesartan Lozartan tasosartan Telmisartan Valsartan Azilsartan medoksomil tasosartan Valsartan azilsartan candesartan cilexetil sparsentan pratosartan 2 Ontologiya genaMolekulyarna funkciya G protein coupled receptor activity angiotensin type II receptor activity angiotensin type I receptor activity signal transducer activity bradykinin receptor binding GO 0001948 GO 0016582 protein binding protein heterodimerization activityKlitinna komponenta integral component of membrane membrana klitinna membrana integral component of plasma membrane vnutrishnoklitinnijBiologichnij proces GO 0051247 GO 0051200 positive regulation of protein metabolic process positive regulation of cytosolic calcium ion concentration involved in phospholipase C activating G protein coupled signaling pathway positive regulation of inflammatory response maintenance of blood vessel diameter homeostasis by renin angiotensin positive regulation of phospholipase A2 activity regulation of renal sodium excretion kidney development positive regulation of cholesterol esterification phospholipase C activating angiotensin activated signaling pathway positive regulation of cytosolic calcium ion concentration angiotensin activated signaling pathway renin angiotensin regulation of aldosterone production phospholipase C activating G protein coupled receptor signaling pathway positive regulation of macrophage derived foam cell differentiation positive regulation of reactive oxygen species metabolic process regulation of vasoconstriction low density lipoprotein particle remodeling regulation of cell population proliferation regulation of cell growth Rho protein signal transduction positive regulation of NAD P H oxidase activity regulation of inflammatory response cell chemotaxis regulation of systemic arterial blood pressure by renin angiotensin calcium mediated signaling GO 0072468 Signalna transdukciya blood vessel diameter maintenance G protein coupled receptor signaling pathway positive regulation of blood vessel endothelial cell proliferation involved in sprouting angiogenesis inflammatory responseDzherela Amigo QuickGOShablon ekspresiyiBilshe danihOrtologiVidi Lyudina MishaEntrez185 11607Ensembl ENSG00000144891 ENSMUSG00000049115UniProt P30556 P29754RefSeq mRNK NM 032049NM 000685NM 004835NM 009585NM 031850NM 001382736NM 001382737NM 177322RefSeq bilok NP 000676NP 004826NP 033611NP 114038NP 114438NP 001369665NP 001369666NP 796296Lokus UCSC Hr 3 148 7 148 74 MbHr 13 30 52 30 57 MbPubMed search 3 4 VikidaniDiv Red dlya lyudejDiv Red dlya mishej Poslidovnist aminokislot1020304050MILNSSTEDGIKRIQDDCPKAGRHNYIFVMIPTLYSIIFVVGIFGNSLVVIVIYFYMKLKTVASVFLLNLALADLCFLLTLPLWAVYTAMEYRWPFGNYLCKIASASVSFNLYASVFLLTCLSIDRYLAIVHPMKSRLRRTMLVAKVTCIIIWLLAGLASLPAIIHRNVFFIENTNITVCAFHYESQNSTLPIGLGLTKNILGFLFPFLIILTSYTLIWKALKKAYEIQKNKPRNDDIFKIIMAIVLFFFFSWIPHQIFTFLDVLIQLGIIRDCRIADIVDTAMPITICIAYFNNCLNPLFYGFLGKKFKRYFLQLLKYIPPKAKSHSNLSTKMSTLSYRPSDNVSSSTKKPAPCFEVEA Alanin C Cisteyin D Asparaginova kislota E Glutaminova kislota F Fenilalanin G Glicin H Gistidin I Izolejcin K Lizin L Lejcin M Metionin N Asparagin P Prolin Q Glutamin R Arginin S Serin T Treonin V Valin W Triptofan Y Tirozin Kodovanij genom bilok za funkciyami nalezhit do receptoriv g bilokspryazhenih receptoriv bilkiv vnutrishnoklitinnogo signalingu fosfoproteyiniv Zadiyanij u takomu biologichnomu procesi yak polimorfizm Lokalizovanij u klitinnij membrani membrani Literatura RedaguvatiMauzy C A Hwang O Egloff A M Wu L H Chung F Z 1992 Cloning expression and characterization of a gene encoding the human angiotensin II type 1A receptor Biochem Biophys Res Commun 186 277 284 PubMed DOI 10 1016 S0006 291X 05 80804 6 Furuta H Guo D F Inagami T 1992 Molecular cloning and sequencing of the gene encoding human angiotensin II type 1 receptor Biochem Biophys Res Commun 183 8 13 PubMed DOI 10 1016 0006 291X 92 91600 U Curnow K M Pascoe L White P C 1992 Genetic analysis of the human type 1 angiotensin II receptor Mol Endocrinol 6 1113 1118 PubMed DOI 10 1210 mend 6 7 1508224 Konishi H Kuroda S Inada Y Fujisawa Y 1994 Novel subtype of human angiotensin II type 1 receptor cDNA cloning and expression Biochem Biophys Res Commun 199 467 474 PubMed DOI 10 1006 bbrc 1994 1252 The status quality and expansion of the NIH full length cDNA project the Mammalian Gene Collection MGC Genome Res 14 2121 2127 2004 PubMed DOI 10 1101 gr 2596504Primitki Redaguvati Zahvoryuvannya genetichno pov yazani z AGTR1 pereglyanuti redaguvati posilannya na VikiDanih Spoluki yaki fizichno vzayemodiyut z Angiotensin II receptor type 1 pereglyanuti redaguvati posilannya na VikiDanih Human PubMed Reference Mouse PubMed Reference HUGO Gene Nomenclature Commitee HGNC 336 angl Procitovano 30 serpnya 2017 UniProt P30556 angl Arhiv originalu za 2 veresnya 2017 Procitovano 30 serpnya 2017 Div takozh RedaguvatiHromosoma 3 nbsp Ce nezavershena stattya pro bilki Vi mozhete dopomogti proyektu vipravivshi abo dopisavshi yiyi Otrimano z https uk wikipedia org w index php title AGTR1 amp oldid 35335000
