CXCL8 angl C X C motif chemokine ligand 8 bilok yakij koduyetsya odnojmennim genom roztashovanim u lyudej na korotkomu plechi 4 yi hromosomi 2 Dovzhina polipeptidnogo lancyuga bilka stanovit 99 aminokislot a molekulyarna masa 11 098 3 CXCL8Nayavni strukturiPDBPoshuk dlya lyudej PDBe RCSBSpisok kodiv PDB3IL8 1ICW 1IKL 1IKM 1IL8 1ILP 1ILQ 1QE6 1ROD 2IL8 4XDXIdentifikatoriSimvoliCXCL8 chemokine C X C motif ligand 8 GCP 1 GCP1 LECT LUCT LYNAP MDNCF MONAP NAF NAP 1 NAP1 IL8 C X C motif chemokine ligand 8 Interleukin 8 SCYB8Zovnishni ID OMIM 146930 HomoloGene 47937 GeneCards CXCL8Ontologiya genaMolekulyarna funkciya cytokine activity GO 0001948 GO 0016582 protein binding interleukin 8 receptor binding chemokine activityKlitinna komponenta extracellular region vnutrishnoklitinnij extracellular spaceBiologichnij proces G protein coupled receptor signaling pathway GO 0007243 intracellular signal transduction chemokine mediated signaling pathway cellular response to tumor necrosis factor receptor internalization cellular response to fibroblast growth factor stimulus response to endoplasmic reticulum stress positive regulation of angiogenesis regulation of single stranded viral RNA replication via double stranded DNA intermediate PERK mediated unfolded protein response induction of positive chemotaxis hemotaksis regulation of cell adhesion GO 0046730 GO 0046737 GO 0046738 GO 0046736 Imunna vidpovid cellular response to interleukin 1 Angiogenez positive regulation of neutrophil chemotaxis inflammatory response negative regulation of G protein coupled receptor signaling pathway response to molecule of bacterial origin cellular response to lipopolysaccharide embryonic digestive tract development GO 0072468 Signalna transdukciya negative regulation of cell population proliferation calcium mediated signaling regulation of entry of bacterium into host cell defense response neutrophil chemotaxis neutrophil activation antimicrobial humoral immune response mediated by antimicrobial peptide regulation of signaling receptor activity cytokine mediated signaling pathway leukocyte chemotaxisDzherela Amigo QuickGOShablon ekspresiyiBilshe danihOrtologiVidi Lyudina MishaEntrez3576 n dEnsembl ENSG00000169429 n dUniProt P10145 n dRefSeq mRNK NM 000584NM 001354840n dRefSeq bilok NP 000575NP 001341769n dLokus UCSC Hr 4 73 74 73 74 Mbn dPubMed search 1 n dVikidaniDiv Red dlya lyudej Poslidovnist aminokislot1020304050MTSKLAVALLAAFLISAALCEGAVLPRSAKELRCQCIKTYSKPFHPKFIKELRVIESGPHCANTEIIVKLSDGRELCLDPKENWVQRVVEKFLKRAENSA Alanin C Cisteyin D Asparaginova kislota E Glutaminova kislota F Fenilalanin G Glicin H Gistidin I Izolejcin K Lizin L Lejcin M Metionin N Asparagin P Prolin Q Glutamin R Arginin S Serin T Treonin V Valin W Triptofan Y Tirozin Kodovanij genom bilok za funkciyeyu nalezhit do citokiniv Zadiyanij u takih biologichnih procesah yak zapalna vidpovid hemotaksis Sekretovanij nazovni Literatura RedaguvatiKowalski J Denhardt D T 1989 Regulation of the mRNA for monocyte derived neutrophil activating peptide in differentiating HL60 promyelocytes Mol Cell Biol 9 1946 1957 PubMed DOI 10 1128 MCB 9 5 1946 The status quality and expansion of the NIH full length cDNA project the Mammalian Gene Collection MGC Genome Res 14 2121 2127 2004 PubMed DOI 10 1101 gr 2596504 van Damme J van Beeumen J Conings R Decock B Billiau A 1989 Purification of granulocyte chemotactic peptide interleukin 8 reveals N terminal sequence heterogeneity similar to that of beta thromboglobulin Eur J Biochem 181 337 344 PubMed DOI 10 1111 j 1432 1033 1989 tb14729 x Golds E E Mason P Nyirkos P 1989 Inflammatory cytokines induce synthesis and secretion of gro protein and a neutrophil chemotactic factor but not beta 2 microglobulin in human synovial cells and fibroblasts Biochem J 259 585 588 PubMed DOI 10 1042 bj2590585 Gregory H Young J Schroeder J M Mrowietz U Christophers E 1988 Structure determination of a human lymphocyte derived neutrophil activating peptide LYNAP Biochem Biophys Res Commun 151 883 890 PubMed DOI 10 1016 S0006 291X 88 80364 4 Walz A Peveri P Aschauer H Baggiolini M 1987 Purification and amino acid sequencing of NAF a novel neutrophil activating factor produced by monocytes Biochem Biophys Res Commun 149 755 761 PubMed DOI 10 1016 0006 291X 87 90432 3Primitki Redaguvati Human PubMed Reference HUGO Gene Nomenclature Commitee HGNC 6025 angl Arhiv originalu za 15 chervnya 2017 Procitovano 30 serpnya 2017 UniProt P10145 angl Arhiv originalu za 20 serpnya 2017 Procitovano 30 serpnya 2017 Div takozh RedaguvatiHromosoma 4 nbsp Ce nezavershena stattya pro bilki Vi mozhete dopomogti proyektu vipravivshi abo dopisavshi yiyi Otrimano z https uk wikipedia org w index php title Interlejkin 8 amp oldid 38242149
