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S agach Vad im F edorovich ukrayinskij vchenij patofizolog doktor medichnih nauk profesor chlen korespondent NAN Ukrayini zaviduvach viddilom fiziologiyi krovoobigu Institutu fiziologiyi imeni O O Bogomolcya NAN Ukrayini Sagach Vadim FedorovichNarodivsya 21 veresnya 1943 1943 09 21 80 rokiv Ulyanivska oblast SRSRMisce prozhivannya UkrayinaKrayina UkrayinaDiyalnist naukovecAlma mater Sankt Peterburzkij derzhavnij medichnij universitetGaluz patologichna fiziologiya kardiologiya fiziologiya imunologiyaZaklad Institut fiziologiyi imeni O O Bogomolcya NAN UkrayiniVchene zvannya profesor chlen korespondent NAN UkrayiniNaukovij stupin doktor medichnih naukNaukovij kerivnik Mikola GoryevVidomij zavdyaki eksperimentalna kardiologiya doslidzhennya NO sintaziNagorodi Premiya NAN Ukrayini imeni O O Bogomolcya Zmist 1 Rodina 2 Osvita i profesijna diyalnist 3 Naukova diyalnist 4 Naukova diyalnist za mezhami Ukrayini 5 Pedagogichna diyalnist 6 Nagorodi 7 Osnovni naukovi publikaciyi 7 1 Statti u recenzovanih naukovih zhurnalah 7 2 Monografiyi 8 Primitki 9 Dzherela 10 PosilannyaRodina RedaguvatiBatko Sagach Fedir Petrovich istorik obijmav posadu prorektora Hersonskogo pedagogichnogo institutu im N K Krupskoyi Mati Golovko Akilina Fedotivna obijmala posadu direktora Hersonskoyi shkoli 15 na toj moment yedinoyi ukrayinskoyi shkoli v m Herson uchitel biologiyi Zasluzhenij vchitel Ukrayini Brat Sagach Stanislav Fedorovich inzhener korablebudivnik U shlyubi z Panchenko Lyudmiloyu Vasilivnoyu maye donku Sagach Viktoriyu Vadimivnu likar pediatr ta onuka Adriana Osvita i profesijna diyalnist RedaguvatiV 1966 roci zakinchiv Leningradskij medichnij institut Z 1966 po 1967 rik prohodiv strokovu vijskovu sluzhba v medichnomu sanitarnomu bataljoni u s m t Pechenga Murmanskoyi oblasti de obijmav posadu likarya toksikologa i zaviduvacha prijmalnogo viddilennya Z 1968 po 1969 rik pracyuvav likarem sanitarno karantinnogo viddilu SES v Hersonskomu morskomu portu Z 1970 po 1973 rik navchavsya v aspiranturi Institutu fiziologiyi im O O Bogomolcya v laboratoriyi patologiyi krovoobigu de vikonuvav naukovu robotu pid kerivnictvom akademika AMN SRSR M M Goryeva V 1974 roci zahistiv kandidatsku disertaciyu Modelyuvannya i gemodinamichna harakteristika distrofichnih poshkodzhen miokarda U 1974 1986 rokah molodshij a potim starshij naukovij spivrobitnik viddilu eksperimentalnoyi kardiologiyi pid kerivnictvom akademika NAN Ukrayini O O Mojbenka V 1986 r zahistiv doktorsku disertaciyu Mehanizmi porushennya kardio i gemodinamiki imunnogo genezu Z 1 bereznya 1986 roku i po teperishnij chas zaviduvach viddilu fiziologiyi krovoobigu Institutu fiziologiyi im O O Bogomolcya Z 1993 roku profesor za fahom patologichna fiziologiya a v 1995 roci obranij chlenom korespondentom NAN Ukrayini za fahom fiziologiya lyudini i tvarin Z 1992 po 2015 rik zastupnik direktora z naukovoyi roboti Institutu fiziologiyi im O O Bogomolcya Naukova diyalnist RedaguvatiV F Sagach vidomij fahivec u galuzi biohimiyi fiziologiyi ta patologichnoyi fiziologiyi sercevo sudinnoyi sistemi Svoyi pershi kroki v nauci Vadim Fedorovich zrobiv na kafedri patologichnoyi fiziologiyi pid kerivnictvom vidomogo patofiziologa Leonida Ruvimovicha Perelmana navchayuchis v medichnomu instituti V jogo naukovomu dorobku vpershe opisana nizka nevidomih ranishe yavish i mehanizmiv funkcionuvannya organizmu ta rozvitku patologichnih procesiv Rezultatom jogo rannih doslidzhen stala rozrobka originalnoyi modeli lokalnogo imunogennogo ushkodzhennya tkanin miokarda Buli doslidzhenni mehanizmi imunogennih porushen diyalnosti sercya ta rozvitku sercevo sudinnoyi nedostatnosti sho suprovodzhuvala infarkt miokarda imunnogo pohodzhennya Profesorom Sagachem vpershe pokazano sho rozvitok fundamentalnih sudinnih reakcij reaktivnoyi i funkcionalnoyi giperemiyi ye endotelij zalezhnim procesom ta zumovlenij diyeyu oksidu azotu NO V F Sagach obgruntuvav virishalnu rol sintezu oksidu azotu v realizaciyi fundamentalnogo mehanizmu regulyaciyi skorotlivoyi aktivnosti miokarda zakonu Franka Starlinga V ostanni roki profesor Sagach doslidzhuye rol endogennogo sirkovodnyu v reakciyah sercevo sudinnoyi sistemi ta rozvitku yiyi patologichnih zmin Pokazano zmenshennya jogo sintezu pri starinni arterialnij gipertenziyi ta zbilshennya pri fizichnomu trenuvanni Dovedeno jogo velike znachennya u zminah funkciyi sercya i sudin pri cih stanah a takozh viznachna rol u reakciyi na ishemiyu reperfuziyu i v efektivnosti zakonu Franka Starlinga Dovedeno sho kardio i vaskuloprotektornij vpliv sirkovodnyu zumovlenij jogo zdatnistyu prignichuvati rozvitok oksidativnogo i nitrozativnogo stresu vidkrivannya mitohondrialnoyi pori a takozh vidnovlyuvati spryazhenij stan konstitutivnoyi NO sintazi V F Sagach ye avtorom ta spivavtorom 928 publikacij z yakih 2 monografiyi 445 statej ta 18 patentiv nadrukovanih u vitchiznyanih ta zakordonnih naukovih vidannyah Vadim Fedorovich talanovitij pedagog i vihovatel naukovih kadriv pidgotuvav 5 doktoriv i 21 kandidativ medichnih ta biologichnih nauk Jogo visokokvalifikovani vihovanci ocholyuyut kafedri ta pracyuyut u providnih laboratoriyah SShA Velikoyi Britaniyi Belgiyi ta Avstriyi Z 1995 roku golovnij redaktor odnogo z providnih naukovih zhurnaliv Ukrayini Fiziologichnogo zhurnalu NAN Ukrayini z 2010 International Journal of Physiology and of Pathophysiology SShA chlen redkolegiyi zhurnalu Krovoobig ta gemostaz Uprodovzh 37 rokiv profesor V F Sagach ye chlenom ta zastupnikom golovi specializovanoyi vchenoyi radi pri Instituti fiziologiyi im O O Bogomolcya NAN Ukrayini 6 rokiv buv zastupnikom golovi ekspertnoyi radi VAK z biologichnih nauk 4 roki chlenom Prezidiyi VAK Ukrayini Naukova diyalnist za mezhami Ukrayini Redaguvati1995 1996 doslidzhennya z vivchennya roli oksidu azotu NO v mehanizmi Franka Starlinga z profesorom A M Shah m Kardif Spoluchene Korolivstvo Velikoyi Britaniyi ta Pivnichnoyi Irlandiyi 2000 doslidzhennya z vivchennya vplivu aneksinu II na skorotlivu aktivnist i Ca2 tranziyenti izolovanih kardiomiocitiv z profesorom E Lakatta odnim iz providnih svitovih naukovciv u galuzi starinnya sercevo sudinnoyi sistemi m Baltimor SShA 2001 doslidzhennya z vstanovlennya vplivu vodorozchinnogo vitaminu E na reakciyu izolovanogo sercya pri ishemiyi reperfuziyi z profesorom Claudio Galli m Milan Italiya Pedagogichna diyalnist RedaguvatiZ 1993 roku profesor kafedri fiziologiyi Nacionalnogo universitetu im Tarasa Shevchenka chitaye lekciyi iz fiziologiyi sercevo sudinnoyi sistemi ta osnovi patologichnoyi fiziologiyi Nagorodi RedaguvatiDerzhavna premiya Ukrayini v galuzi nauki i tehniki 2003 roku za cikl naukovih prac Doslidzhennya fundamentalnih mehanizmiv diyi oksidu azotu na sercevo sudinnu sistemu yak osnovi patogenetichnogo likuvannya yiyi zahvoryuvan u skladi kolektivu Derzhavna premiya Ukrayini v galuzi nauki i tehniki 1996 roku za cikl naukovih prac Rol spoluk endotelialnogo pohodzhennya v regulyaciyi krovoobigu i diyalnosti sercya u skladi kolektivu Premiya im O O Bogomolcya NAN Ukrayini 1994 roku za monografiyu Imunogenni porushennya diyalnosti sercevo sudinnoyi sistemi u spivavtorstvi Osnovni naukovi publikaciyi RedaguvatiStatti u recenzovanih naukovih zhurnalah Redaguvati Akopova Olga Kolchinskaya Liudmila Nosar Valentina Mankovska Iryna Sagach V F 2020 Diazoxide affects mitochondrial bioenergetics by the opening of mKATP channel on submicromolar scale BMC Molecular and Cell Biology 21 N 31 1 Pepper Chris B Mebazaa Alexandre Prendergast Bernard D Yang Zhao Kang Draper Nick J Sagach V F Shah Ajay M 2020 Endothelial Regulation of Cardiac Myofilament Responsiveness to Calcium In book Endothelial Modulation of Cardiac Function pp 185 203 2 Natalya Dorofeyeva Konstantin Drachuk Rajasekaran Rajkumar Sagach V F 2020 H 2 S donor improves heart function and vascular relaxation in Diabetes European Journal of Clinical Investigation 3 NA Dorofeyeva IP Korkach OE Kutsyk Sagach V F 2020 Modulation of hydrogen sulfide synthesis improve heart function and endothelium dependent vasorelaxation in diabetes Canadian Journal of Physiology and Pharmacology 4 Mys L A Strutynska N A Goshovska Y V Sagach V F 2019 Stimulation of the endogenous hydrogen sulfide synthesis suppresses oxidative nitrosative stress and restores endothelial dependent vasorelaxation in old rats Canadian Journal of Physiology and Pharmacology 98 5 275 281 5 Bondarenko Alexander I Montecucco Fabrizio Panasiuk Olga Sagach V F Sidoryak Nataliya Brandt Karim J Mach Francois 2017 GPR55 agonist lysophosphatidylinositol and lysophosphatidylcholine inhibit endothelial cell hyperpolarization via GPR independent suppression of Na Ca2 exchanger and endoplasmic reticulum Ca2 refilling Vascular Pharmacology 89 39 48 6 Mys L A Budko A Y Strutynska N A Sagach V F 2017 Pyridoxal 5 phosphate restores hydrogen sulfide synthes and redox state of heart and blood vessels tissue in old animals Fiziol Zhurnal 63 1 3 9 1 Akopova Olga Nosar Valentina Gavenauskas Bronislav Bratus Larissa Kolchinskaya Liudmila Mankovska Iryna Sagach V F 2016 The effect of atp dependent potassium uptake on mitochondrial functions under acute hypoxia Journal of Bioenergetics and Biomembranes 48 67 75 7 Akopova Olga Kotsiuruba Anatoly Korkach Yulia Kolchinskaya Liudmila Nosar Valentina Gavenauskas Bronislav Serebrovska Zoya Mankovska Iryna Sagach V F 2016 The Effect Of NO Donor on Calcium Uptake and Reactive Nitrogen Species Production in Mitochondria Cellular Physiology and Biochemistry 39 193 204 8 Drachuk K O Dorofeyeva N A Sagach V F 2016 The role of hydrogen sulfide in diastolic function restoration during aging Fiziol Zhurnal 62 6 9 18 2 Dorofeyeva N A Kuzmenko M O Shimanskaya T V Sagach V F 2013 Cardiohemodynamics and Efficiency of the Frank Starling Mechanism in Spontaneously Hypertensive Rats International Journal of Physiology and Pathophysiology 4 1 17 26 3 Bondarenko A I Drachuk K O Panasiuk O Sagach V F Deak A T Malli R et al 2013 N arachidonoyl glycine suppresses Na Ca2 exchanger mediated Ca2 entry into endothelial cells and activates BKCa channels independently of GPCRs British Journal of Pharmacology 169 4 933 948 4 Sagach V Bondarenko A Bazilyuk O Kotsuruba A 2006 Endothelial dysfunction possible mechanisms and ways of correction Experimental amp Clinical Cardiology 11 2 107 10 5 Mojbenko O O Sagach V F Tkachenko M M Korkushko O V Bezrukov V V Kulchickij O K ta inshi 2004 Fundamentalni mehanizmi diyi oksidu azotu na sercevo sudinnu sistemu yak osnovi patogenetichnogo likuvannya zahvoryuvan Fiziol zhurnal 50 1 11 30 6 Sagach V F Scrosati M Fielding J Rossoni G Galli C Visioli F 2002 The water soluble vitamin E analogue Trolox protects against ischaemia reperfusion damage in vitro and ex vivo A comparison with vitamin E Pharmacological research 45 6 435 439 7 Prendergast B D Sagach V F Shah A M 1997 Basal release of nitric oxide augments the Frank Starling response in the isolated heart Circulation 96 4 1320 29 8 Sagach V F Kindybalyuk A M Kovalenko T N 1992 Functional hyperemia of skeletal muscle role of endothelium Journal of Cardiovascular Pharmacology 20 170 5 9 Shapoval L N Sagach V F Pobegailo L S 1991 Nitric oxide influences ventrolateral medullary mechanisms of vasomotor control in the cat Neuroscience Letters 132 1 47 50 10 Monografiyi Redaguvati Mojbenko O O Sagach V F 1992 Immunogennye narusheniya deyatelnosti serdechno sosudistoj sistemy K Naukova dumka 202 ros Primitki Redaguvati Akopova Olga Kolchinskaya Liudmila Nosar Valentina Mankovska Iryna Sagach Vadim 19 kvitnya 2020 Diazoxide affects mitochondrial bioenergetics by the opening of mKATP channel on submicromolar scale BMC Molecular and Cell Biology 21 1 s 31 ISSN 2661 8850 PMC PMC7168813 PMID 32306897 doi 10 1186 s12860 020 00275 0 Procitovano 3 listopada 2020 Ito Hiroshi 29 sichnya 2020 Endothelin and Cardiac Hypertrophy Endothelial Modulation of Cardiac Function CRC Press s 139 155 ISBN 978 0 367 81055 9 Dorofeyeva Natalya Drachuk Konstantin Rajkumar Rajasekaran Sabnis Omkar Sagach Vadim H2S donor improves heart function and vascular relaxation in diabetes European Journal of Clinical Investigation angl n a n a s e13354 ISSN 1365 2362 doi 10 1111 eci 13354 Procitovano 3 listopada 2020 Dorofeyeva Dr Natalya A Korkach Dr Iulia P Kutsyk Miss Olena E Sagach Prof Vadim 16 zhovtnya 2020 Modulation of hydrogen sulfide synthesis improve heart function and endothelium dependent vasorelaxation in diabetes https doi org 10 1139 cjpp 2020 0302 angl doi 10 1139 cjpp 2020 0302 Procitovano 3 listopada 2020 Mys L A Strutynska N A Goshovska Y V Sagach V F 17 grudnya 2019 Stimulation of the endogenous hydrogen sulfide synthesis suppresses oxidative nitrosative stress and restores endothelial dependent vasorelaxation in old rats Canadian Journal of Physiology and Pharmacology angl doi 10 1139 cjpp 2019 0411 Procitovano 3 listopada 2020 Bondarenko Alexander I Montecucco Fabrizio Panasiuk Olga Sagach Vadim Sidoryak Nataliya Brandt Karim J Mach Francois 1 lyutogo 2017 GPR55 agonist lysophosphatidylinositol and lysophosphatidylcholine inhibit endothelial cell hyperpolarization via GPR independent suppression of Na Ca2 exchanger and endoplasmic reticulum Ca2 refilling Vascular Pharmacology angl 89 s 39 48 ISSN 1537 1891 doi 10 1016 j vph 2017 01 002 Procitovano 3 listopada 2020 Akopova Olga Nosar Valentina Gavenauskas Bronislav Bratus Larissa Kolchinskaya Liudmila Mankovska Iryna Sagach Vadim 1 lyutogo 2016 The effect of atp dependent potassium uptake on mitochondrial functions under acute hypoxia Journal of Bioenergetics and Biomembranes angl 48 1 s 67 75 ISSN 1573 6881 doi 10 1007 s10863 015 9642 8 Procitovano 3 listopada 2020 Akopova Olga Kotsiuruba Anatoly Korkach Yulia Kolchinskaya Liudmila Nosar Valentina Gavenauskas Bronislav Serebrovska Zoya Mankovska Iryna ta in 2016 The Effect Of NO Donor on Calcium Uptake and Reactive Nitrogen Species Production in Mitochondria Cellular Physiology and Biochemistry english 39 1 s 193 204 ISSN 1015 8987 PMID 27336612 doi 10 1159 000445616 Procitovano 3 listopada 2020 rekomenduyetsya displayauthors dovidka Dzherela RedaguvatiNACIONALNA AKADEMIYa NAUK UKRAYiNI personalnij sklad 353 Viddil fiziologiyi krovoobigu Institutu fiziologiyi im O O Bogomolcya 11 ENCIKLOPEDIYa Kiyivskogo nacionalnogo universitetu imeni Tarasa Shevchenka 12 Golovnomu redaktoru Fiziologichnogo zhurnalu Sagachu Vadimu Fedorovichu 75 rokiv Fiziologichnij zhurnal 2018 64 5 3 7 13 Fiziologichnij zhurnal 2013 59 4 3 7 14 Akademik Nikolaj Nikolaevich Gorev Stranicy zhizni 2010 5 17 Rozvitok patofiziologiyi v Ukrayini 2009 80 83 Fiziologichnij zhurnal 2003 49 4 3 6 15 Posilannya RedaguvatiVadim Sagach Prof MD PhD ResearcGateVadim Sagach Prof MD PhD Google ScholarVadim Sagach Prof MD PhD Begell House nbsp Ce nezavershena stattya pro ukrayinskogo naukovcya Vi mozhete dopomogti proyektu vipravivshi abo dopisavshi yiyi Otrimano z https uk wikipedia org w index php title Sagach Vadim Fedorovich amp oldid 34156839