Tiroksin zv yazuvalnij globulin angl thyroxine binding globulin TBG ce bilok globulin sho zv yazuyetsya z gormonami shitopodibnoyi zalozi pid chas perenesennya ostannih krovotokom Ce odin z troh bilkiv razom z transtiretinom i sirovatkovim albuminom sho vidpovidayut za perenesennya krovotokom gormoniv shitopodibnoyi zalozi tiroksinu T4 i 3 5 3 trijodtironinu T3 Z cih troh bilkiv tiroksin zv yazuvalnij globulin maye najvishu afinnist do T4 i T3 ale prisutnij v najnizhchij koncentraciyi Popri nizku koncentraciyu TBG perenosit bilshu chastinu T4 v plazmi krovi Cherez duzhe nizku koncentraciyu T4 i T3 v krovi nasichennya TBG ligandom ridko perevishuye 25 Na vidminu vid transtiretinu i albuminu v TBG ye odin sajt zv yazuvannya dlya T4 T3 Tiroksin zv yazuvalnij globulin sintezuyetsya golovnim chinom pechinci u viglyadi bilka molekulyarna masa yakogo stanovit 54 kDa Tiroksin zv yazuyuchij globulinNayavni strukturiPDBPoshuk ortologiv PDBe RCSBSpisok kodiv PDB2CEO 2RIV 2RIW 2XN3 2XN5 2XN6 2XN7 4X30 4YIAIdentifikatoriSimvoliSERPINA7 TBG serpin family A member 7 Thyroxine binding globulin TBG TBGQTLZovnishni ID OMIM 314200 MGI 3041197 HomoloGene 20113 GeneCards SERPINA7Ontologiya genaMolekulyarna funkciya serine type endopeptidase inhibitor activityKlitinna komponenta ekzosoma extracellular region extracellular spaceBiologichnij proces thyroid hormone transport negative regulation of endopeptidase activityDzherela Amigo QuickGOOrtologiVidi Lyudina MishaEntrez6906 331535Ensembl ENSG00000123561 ENSMUSG00000031271UniProt P05543 P61939RefSeq mRNK NM 000354NM 177920NM 001382371NM 001382372RefSeq bilok NP 000345NP 808588NP 001369300NP 001369301Lokus UCSC Hr X 106 03 106 04 MbHr X 137 98 137 99 MbPubMed search 1 2 VikidaniDiv Red dlya lyudejDiv Red dlya mishejGenomna harakteristika RedaguvatiZ poglyadu genomiki TBG ye serpinom prote vin ne ingibuye serinovi proteazi na vidminu vid inshih chleniv ciyeyi grupi Rol u diagnostici RedaguvatiTBG test inodi zastovuyutsya dlya viznachennya prichin pidvishennya abo zmenshennya rivnya gormoniv shitopodibnoyi zalozi Dzherela RedaguvatiCheng SY 1978 Partial amino acid sequence of human thyroxine binding globulin Further evidence for a single polypeptide chain Biochem Biophys Res Commun 79 4 1212 8 PMID 414747 doi 10 1016 0006 291X 77 91135 4 Shirotani T Kishikawa H Wake N etal 1993 Thyroxine binding globulin variant TBG Kumamoto identification of a point mutation and genotype analysis of its family Endocrinol Jpn 39 6 577 84 PMID 1294376 doi 10 1507 endocrj1954 39 577 Bertenshaw R Sarne D Tornari J etal 1992 Sequencing of the variant thyroxine binding globulin TBG San Diego reveals two nucleotide substitutions Biochim Biophys Acta 1139 4 307 10 PMID 1515456 doi 10 1016 0925 4439 92 90105 v Bertenshaw R Takeda K Refetoff S 1991 Sequencing of the variant thyroxine binding globulin TBG Quebec reveals two nucleotide substitutions Am J Hum Genet 48 4 741 4 PMC 1682945 PMID 1901689 Imamura S Mori Y Murata Y etal 1991 Molecular cloning and primary structure of rat thyroxine binding globulin Biochemistry 30 22 5406 11 PMID 1903654 doi 10 1021 bi00236a012 Janssen OE Takeda K Refetoff S 1991 Sequence of the variant thyroxine binding globulin TBG in a Montreal family with partial TBG deficiency Hum Genet 87 2 119 22 PMID 1906047 doi 10 1007 BF00204164 Yamamori I Mori Y Seo H etal 1991 Nucleotide deletion resulting in frameshift as a possible cause of complete thyroxine binding globulin deficiency in six Japanese families J Clin Endocrinol Metab 73 2 262 7 PMID 1906892 doi 10 1210 jcem 73 2 262 Li P Janssen OE Takeda K etal 1991 Complete thyroxine binding globulin TBG deficiency caused by a single nucleotide deletion in the TBG gene Metab Clin Exp 40 11 1231 4 PMID 1943753 doi 10 1016 0026 0495 91 90221 h Waltz MR Pullman TN Takeda K etal 1990 Molecular basis for the properties of the thyroxine binding globulin slow variant in American blacks J Endocrinol Invest 13 4 343 9 PMID 2115061 doi 10 1007 bf03349576 Mori Y Takeda K Charbonneau M Refetoff S 1990 Replacement of Leu227 by Pro in thyroxine binding globulin TBG is associated with complete TBG deficiency in three of eight families with this inherited defect J Clin Endocrinol Metab 70 3 804 9 PMID 2155256 doi 10 1210 jcem 70 3 804 Takeda K Mori Y Sobieszczyk S etal 1989 Sequence of the variant thyroxine binding globulin of Australian aborigines Only one of two amino acid replacements is responsible for its altered properties J Clin Invest 83 4 1344 8 PMC 303827 PMID 2495303 doi 10 1172 JCI114021 Mori Y Seino S Takeda K etal 1989 A mutation causing reduced biological activity and stability of thyroxine binding globulin probably as a result of abnormal glycosylation of the molecule Mol Endocrinol 3 3 575 9 PMID 2501669 doi 10 1210 mend 3 3 575 Flink IL Bailey TJ Gustafson TA etal 1986 Complete amino acid sequence of human thyroxine binding globulin deduced from cloned DNA close homology to the serine antiproteases Proc Natl Acad Sci U S A 83 20 7708 12 PMC 386790 PMID 3094014 doi 10 1073 pnas 83 20 7708 Janssen OE Chen B Buttner C etal 1996 Molecular and structural characterization of the heat resistant thyroxine binding globulin Chicago J Biol Chem 270 47 28234 8 PMID 7499319 doi 10 1074 jbc 270 47 28234 Mori Y Miura Y Oiso Y etal 1995 Precise localization of the human thyroxine binding globulin gene to chromosome Xq22 2 by fluorescence in situ hybridization Hum Genet 96 4 481 2 PMID 7557975 doi 10 1007 BF00191811 Miura Y Mori Y Yamamori I etal 1994 Sequence of a variant thyroxine binding globulin TBG in a family with partial TBG deficiency in Japanese TBG PDJ Endocr J 40 1 127 32 PMID 7951486 doi 10 1507 endocrj 40 127 Hayashi Y Mori Y Janssen OE etal 1993 Human thyroxine binding globulin gene complete sequence and transcriptional regulation Mol Endocrinol 7 8 1049 60 PMID 8232304 doi 10 1210 me 7 8 1049 Akbari MT Kapadi A Farmer MJ etal 1994 The structure of the human thyroxine binding globulin TBG gene Biochim Biophys Acta 1216 3 446 54 PMID 8268226 doi 10 1016 0167 4781 93 90013 4 Mori Y Miura Y Takeuchi H etal 1996 Gene amplification as a cause of inherited thyroxine binding globulin excess in two Japanese families J Clin Endocrinol Metab 80 12 3758 62 PMID 8530630 doi 10 1210 jc 80 12 3758 Carvalho GA Weiss RE Vladutiu AO Refetoff S 1998 Complete deficiency of thyroxine binding globulin TBG CD Buffalo caused by a new nonsense mutation in the thyroxine binding globulin gene Thyroid 8 2 161 5 PMID 9510125 doi 10 1089 thy 1998 8 161 Human PubMed Reference Mouse PubMed Reference Otrimano z https uk wikipedia org w index php title Tiroksin zv 27yazuvalnij globulin amp oldid 38132779
